Development of clinically translatable MRI methodologies for the thoracic spinal cord

胸脊髓临床可转化 MRI 方法的开发

• 批准号: 10728689
• 负责人: Kristin Poole O'Grady
• 金额: $ 17.5万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10728689
• 关键词: Abscess; Acute Disseminated Encephalomyelitis; Address; Air; Anatomy; Anisotropy; Applications Grants; Astrocytoma; Attention; Brain; Breathing; CD2 gene; Cardiac; Cervical; Cervical spinal cord structure; Chemicals; Chest; Chest imaging; Claustrophobias; Clinical; Clinical Management; Clinical Protocols; Collaborations; Communities; Computer software; Data; Development; Diagnosis; Diffuse; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Disease model; Dural Arteriovenous Fistulas; Early treatment; Echo-Planar Imaging; Ependymoma; Evaluation; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Heart; Human Pathology; Image; Inflammatory; Ischemia; Liquid substance; Literature; Lumbar Regions; Lumbar spinal cord structure; Lung; Magnetic Resonance Imaging; Magnetism; Methodology; Methods; Monitor; Morphologic artifacts; Motion; Multiple Sclerosis; Noise; Pain; Pathology; Patient Care; Patient-Focused Outcomes; Patients; Physiological; Predisposition; Protocols documentation; Recovery; Reproducibility; Research; Resolution; Respiration; Respiratory Diaphragm; Rest; Scanning; Secondary to; Signal Transduction; Speed; Spinal Cord; Structure; T2 weighted imaging; Techniques; Testing; Thoracic spinal cord structure; Time; Tissues; Translational Research; Translations; Trauma; Work; anatomic imaging; bone; clinical care; clinical development; clinical practice; clinical translation; clinically relevant; cohort; gray matter; healthy volunteer; hemangioblastoma; high resolution imaging; image translation; imaging modality; imaging scientist; improved; indexing; innovation; method development; multiple sclerosis patient; neuroimaging; patient population; rapid diagnosis; research study; respiratory; spinal cord imaging; spine bone structure; tool; translational scientist; treatment planning; tumor; white matter

PROJECT SUMMARY Magnetic resonance imaging (MRI) is critical to diagnosing pathology of the human spinal cord for a wide array of diseases, conditions, and trauma. The thoracic region of the spinal cord, corresponding to vertebral levels T1-T12, is frequently involved in conditions such as cord ischemia, dural arteriovenous fistulas, and hemangioblastoma as well as inflammatory diseases such as multiple sclerosis (MS). There is a clear need for high quality, nondegraded MRI of the thoracic cord to support diagnosis and treatment planning in the clinical setting as well as to provide comprehensive evaluation of the spinal cord in translational research studies. Unfortunately, MRI methods development for this anatomy significantly lags that for the brain and cervical spinal cord. The thoracic spinal cord is especially challenging to image because, in addition to small size, physiological motion, and low intra-cord tissue contrast between gray and white matter, this region is directly adjacent to the lungs and diaphragm and suffers the most from respiration artifacts relative to the cervical and lumbar regions. Respiration artifacts are caused by the physical motion of the lungs and diaphragm as well as the temporally varying B0 field homogeneity. Conventional, clinical MRI techniques for the thoracic spinal cord are often degraded by these artifacts which can necessitate re-acquisition (lengthening scan duration) or canceling studies, which can negatively impact clinical management. The overarching goal of this project is to systematically optimize anatomical and diffusion MRI sequences for the thoracic spinal cord that employ clinically translatable techniques to mitigate these technical hurdles with specific attention to motion and respiration artifacts. This goal will be addressed in two aims: Aim 1) Optimize clinically relevant anatomical MRI sequences for the thoracic spinal cord at 3T and Aim 2) Optimize diffusion MRI sequences for the thoracic spinal cord at 3T. Completion of these aims will provide a clinically feasible protocol for improved anatomical and diffusion MRI that addresses an important gap in current spinal cord MRI coverage. Furthermore, this study will generate preliminary data and set the stage for future translational research studies that will implement comprehensive spinal cord imaging to improve our understanding of spinal cord pathologies in patient populations.

项目概要 磁共振成像 (MRI) 对于广泛诊断人类脊髓病理至关重要 一系列疾病、状况和创伤。脊髓的胸部区域，对应于椎骨 T1-T12 水平，经常涉及诸如脊髓缺血、硬脑膜动静脉瘘和 血管母细胞瘤以及炎症性疾病，例如多发性硬化症（MS）。有一个明确的需要 高质量、非退化的胸髓 MRI，支持临床诊断和治疗计划 设置以及在转化研究中提供脊髓的综合评估。 不幸的是，针对该解剖结构的 MRI 方法开发明显落后于大脑和颈椎的 MRI 方法开发。 脊髓。胸脊髓的成像尤其具有挑战性，因为除了尺寸小之外， 生理运动，以及灰质和白质之间的脊髓内组织对比度较低，该区域直接 邻近肺和膈肌，相对于颈椎和膈肌，受到呼吸伪影的影响最大。 腰部区域。呼吸伪影是由肺和隔膜的物理运动以及 随时间变化的 B0 场均匀性。胸脊髓的常规临床 MRI 技术 通常会因这些伪影而降级，从而需要重新采集（延长扫描持续时间）或 取消研究，这可能会对临床管理产生负面影响。该项目的总体目标是 系统地优化胸脊髓的解剖和扩散 MRI 序列， 临床上可转化的技术可以减轻这些技术障碍，特别关注运动和 呼吸伪影。这一目标将通过两个目标来实现： 目标 1) 优化临床相关的解剖结构 3T 胸脊髓 MRI 序列，目标 2) 优化扩散 MRI 序列 胸脊髓3T。这些目标的完成将为改进提供临床上可行的方案 解剖和扩散 MRI 弥补了当前脊髓 MRI 覆盖范围的一个重要差距。 此外，这项研究将产生初步数据，并为未来的转化研究奠定基础 这将实施全面的脊髓成像，以提高我们对脊髓病理学的了解 在患者群体中。