New York Obesity Research Center

纽约肥胖研究中心

• 批准号: 7850171
• 负责人: XAVIER PI-SUNYER
• 金额: $ 2.71万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7850171
• 关键词: New; York; Obesity; Research; Center

DESCRIPTION, OVERALL (provided by applicant): This proposal is a competitive renewal of the New York Obesity Research Center (NYORC). The NYORC has been funded through 5 competitive review cycles and currently includes facilities at St. Luke's-Roosevelt Hospital Center (SLRHC) and Columbia University Medical Center (CUMC). In this cycle we add facilities and investigators at Albert Einstein College of Medicine (AECOM), consisting of an Adipose Tissue Core and an Animal Phenotyping Core, and part of the Molecular Biology/Molecular Genetics Core. The Cores at SLRHC will be unified as a Human Phenotyping Core, consisting of Sub-Cores in Body Composition, Energy Expenditure, Hormone and Metabolite, Ingestive Behavior, and Sleep Disorders. Also at SLRHC there will be an Administrative Core to manage the Center, the Pilot/Feasibility Program (P/F), and the Biostatistics Sub-Core. The major portion of the Molecular Biology/Molecular Genetics Core will continue at CUMC. The General Clinical Research Centers at all 3 sites provide important resources for carrying out clinical and translational research, including the new Mass Spectroscopy Laboratory at CUMC. Other resources are three T32 Training Grants, a DERC at Columbia, and a DRTC at AECOM. The objectives of the Center are: (i) to bring together a critical mass of separately funded independent investigators who share a strong interest in obesity research; (ii) to manage a P/F Program and enrichment activities to promote and test new research ideas, stimulate productivity, and foster the training and development of talented new investigators, (iii) to provide member investigators with cost-efficient experimental and intellectual resources to increase productivity and the range of possible experimental venues; (iv) to bring attention to, and promote research activity in obesity, through the educational enrichment program. Our aim is to create a Center in which the critical elements in discovery constituted by animal models, genomic techniques, and mechanistic clinical investigation are integrated in a manner that encourages inter-disciplinary work and accelerated movement of hypotheses from the laboratory to testing in humans (and vice versa). Our combined institutions have the physical and intellectual resources to carry on this range of activities as envisioned by the NIH "Roadmap" and to serve as a regional resource for investigators conducting obesity research also at other institutions.

描述，总体（由申请人提供）： 该提案是纽约肥胖研究中心（NYORC）的竞争更新。 NYORC通过5个竞争性审查周期提供了资金，目前包括圣卢克斯 - 罗斯福医院中心（SLRHC）和哥伦比亚大学医学中心（CUMC）的设施。在这个周期中，我们在阿尔伯特·爱因斯坦医学院（AECOM）中增加了设施和研究人员，由脂肪组织核心和动物表型核心组成，以及分子生物学/分子遗传学核心的一部分。 SLRHC的核心将被统一为人类表型核心，由人体组成，能量消耗，激素和代谢产物，摄取行为和睡眠障碍组成。同样在SLRHC，将有一个管理中心，飞行员/可行性计划（P/F）和生物统计学子核心的行政核心。分子生物学/分子遗传学核心的主要部分将继续在CUMC。所有3个地点的一般临床研究中心为进行临床和转化研究提供了重要资源，包括CUMC的新质谱实验室。其他资源是三项T32培训补助金，哥伦比亚的DERC和AECOM的DRTC。该中心的目标是：（i）将一大批分别资助的独立研究人员汇集在一起​​，他们对肥胖研究有强烈的兴趣； （ii）管理P/F计划和丰富活动，以促进和测试新的研究思想，刺激生产力，并促进才华横溢的新调查人员的培训和发展，以为成员调查人员提供成本效益的实验和知识资源以增加 生产力和可能的实验场所范围； （iv）通过教育丰富计划引起肥胖症的关注并促进肥胖症的研究活动。我们的目的是创建一个中心，在该中心中，动物模型，基因组技术和机械临床研究构成的发现中的关键要素以鼓励跨学科工作的方式进行整合，并加速了假设从实验室到人类测试的假设运动（反之亦然）。我们合并后的机构具有实质和智力资源，可以按照NIH“路线图”的设想进行这项活动，并作为其他机构进行肥胖研究的调查人员的区域资源。