3/5-Cognitive Neuroscience Task Reliability & Clinical Applications Consortium

3/5-认知神经科学任务可靠性

• 批准号: 7693814
• 负责人: STEVEN M SILVERSTEIN
• 金额: $ 12.21万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7693814
• 关键词: Activities of Daily Living; Address; Awareness; Characteristics; Clinical; Clinical Investigator; Clinical Trials; Clinical assessments; Cognition; Cognitive; Cognitive deficits; Consensus; Data; Development; Electronics; Ensure; Evaluation; Explosion; Floor; Goals; Human; Impaired cognition; Individual; Knowledge; Laboratories; Lead; Length; Life; Literature; Maintenance; Measurement; Measures; Methods; Modification; Neuropsychological Tests; Neurosciences Research; Outcome; Participant; Patients; Perception; Performance; Process; Property; Psychometrics; Reading; Recording of previous events; Recruitment Activity; Research; Retrieval; Sampling; Schizophrenia; Series; Site; Specialist; Standardization; Task Performances; Testing; Time; Translating; Translation Process; Translations; Validation; Work; base; clinical application; cognitive function; cognitive neuroscience; cognitive system; design; drug development; flexibility; functional outcomes; improved; interest; meetings; process optimization; public health relevance; relating to nervous system; response; success; symposium; theories; translational approach; visual control

DESCRIPTION (provided by applicant): Over the past decade there has been a growing awareness of the disabling effects of impaired cognition in individuals with schizophrenia. Along with this new awareness has come an increasing emphasis on the importance of developing new treatments that may positively impact these cognitive deficits. During this same period, the cognitive neuroscience field has seen an explosion of technical advances and new knowledge regarding the neural basis of cognition. Sadly, the translation and application of this cutting edge knowledge and paradigm development to new drug development in schizophrenia has lagged significantly behind overall progress in cognitive neuroscience, in large part due to the lack of data on the measurement properties of tasks used in cognitive neuroscience. This concern spawned the Cognitive Neuroscience Research To Improve Cognition in Schizophrenia (CNTRICS) initiative, which conducted a series of conferences designed to develop consensus on the constructs and paradigms from cognitive neuroscience that are ripe for translation, and the validation and psychometric goals when translating such tasks for use in clinical trials contexts. The current application is a logical and needed extension of the CNTRICS initiative that will begin the translation process for paradigms designed to assess four of the constructs identified as being ripe for translation in the first CNTRICS meeting. We have brought together a collaborative "translation" team that represents significant expertise from the many fields necessary for the success of this endeavor, including both basic and clinical cognitive neuroscientists, psychometricians, and clinical trials specialists. We have chosen to focus on four constructs that span both early (gain control and visual integration in perception) and higher-level (goal maintenance, relational encoding and retrieval) components of human cognitive processing. By examining multiple mechanisms, we will be able to establish the generality of the translational approach we propose across different levels and types of cognitive mechanisms. Specific Aim 1 is to validate (in both individuals with schizophrenia and comparison participants) optimized versions of the paradigms that assess our four constructs of interest, as well as to examine the relationship of task performance to clinical and functional outcomes in schizophrenia. By optimization, we mean examining modifications on already validated paradigms that are designed to: 1) minimize task length; 2) simplify task administration across multiple sites; 3) maximize sensitivity and selectivity in assessing the specific cognitive mechanisms of interest; and 4) enhance reliability and minimize floor and ceiling effects. By validation, we mean ensuring that such optimizations designed to enhance the psychometric properties of the task do not alter its construct validity. Specific Aim 2 will be to assess and optimize test-retest reliability and practice effects for the task versions validated in Specific Aim 1. PROJECT NARRATIVE This project has high relevance for public health by significantly improving our ability to translate paradigms developed into the basic cognitive neuroscience literature for use in clinical trials aimed at improving cognition in schizophrenia. Cognitive deficits in schizophrenia are a major predictor of functional outcome in this debilitating illness. Thus, we need to improve our methods for detecting and enhancing cognitive function in schizophrenia in order to help individuals with this illness lead more productive and fulfilling lives.

描述（由申请人提供）：在过去的十年中，人们越来越意识到精神分裂症患者认知受损所造成的残疾影响。随着这种新意识的出现，人们越来越重视开发可能对这些认知缺陷产生积极影响的新疗法的重要性。在同一时期，认知神经科学领域出现了关于认知神经基础的技术进步和新知识的爆炸式增长。遗憾的是，这种前沿知识和范式开发在精神分裂症新药开发中的转化和应用明显落后于认知神经科学的整体进展，这在很大程度上是由于缺乏认知神经科学中使用的任务的测量特性的数据。这种担忧催生了“改善精神分裂症认知的认知神经科学研究”(CNTRICS) 计划，该计划举办了一系列会议，旨在就成熟的认知神经科学翻译框架和范式达成共识，以及翻译此类研究时的验证和心理测量目标。用于临床试验环境中的任务。当前的应用程序是 CNTRICS 计划的逻辑和必要的扩展，该计划将开始范式的翻译过程，这些范式旨在评估在第一次 CNTRICS 会议上被确定为成熟翻译的四个结构。我们聚集了一个协作“翻译”团队，该团队代表了这一努力成功所必需的许多领域的重要专业知识，包括基础和临床认知神经科学家、心理测量学家和临床试验专家。我们选择关注四种结构，涵盖人类认知处理的早期（获得控制和感知中的视觉整合）和更高层次（目标维护、关系编码和检索）组成部分。通过检查多种机制，我们将能够建立我们在不同层次和类型的认知机制中提出的转化方法的普遍性。具体目标 1 是验证（在精神分裂症患者和对照参与者中）评估我们感兴趣的四种结构的范式的优化版本，以及检查任务绩效与精神分裂症临床和功能结果的关系。通过优化，我们的意思是检查对已经验证的范式的修改，这些范式旨在：1）最小化任务长度； 2) 简化跨多个站点的任务管理； 3）最大限度地提高评估感兴趣的特定认知机制的敏感性和选择性； 4) 提高可靠性并最大限度地减少地板和天花板效应。通过验证，我们的意思是确保这种旨在增强任务心理测量特性的优化不会改变其结构有效性。具体目标 2 将是评估和优化在具体目标 1 中验证的任务版本的重测可靠性和实践效果。 项目叙述 该项目通过显着提高我们将开发的范式转化为基础认知神经科学的能力，与公共健康具有高度相关性用于旨在改善精神分裂症认知的临床试验的文献。精神分裂症的认知缺陷是这种使人衰弱的疾病功能结果的主要预测因素。因此，我们需要改进检测和增强精神分裂症认知功能的方法，以帮助患有这种疾病的人过上更富有成效和更充实的生活。