Communication of Genetic and Environmental Risks in Colorectal Cancer Prevention

结直肠癌预防中遗传和环境风险的交流

基本信息

批准号：
7932002
负责人：
Catharine Wang
金额：
$ 13.5万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7932002
关键词：
Adherence Adoption Age Area Award Awareness Behavior Behavior Therapy Behavioral Belief Cancer Etiology Cancer Survivor Categories Chronic Disease Cognitive Colonoscopy Colorectal Colorectal Cancer Communication Complex Data Development Diagnosis Diet Disease Eating Effectiveness Environment Environmental Risk Factor Evaluation Event Family Cancer History Family health status Family history of Feedback Female Foundations Future Gender General Population Genes Genetic Genetic Determinism Genetic Risk Goals Health Health Benefit Health Communication Health behavior Heredity Human Genome Individual Informal Social Control Inherited Intake Intervention Knowledge Life Style Light Malignant Neoplasms Mediating Medical Mentors Methods Modeling Motivation Nature Outcome Pattern Play Predisposing Factor Prevention Preventive Principal Investigator Process Protocols documentation Psychological adjustment Psychometrics Public Domains Public Health Recommendation Recording of previous events Regimen Research Research Methodology Research Personnel Research Support Research Training Risk Risk Factors Role Science Screening for cancer Screening procedure Severities Sigmoidoscopy Statistical Methods Surgeon Surveys Testing Time Training Training Programs Translating Work base behavior change behavior influence cancer diagnosis cancer genetics cancer risk cancer site career colorectal cancer prevention colorectal cancer screening coping design disorder risk fruits and vegetables genetic technology genome sequencing high risk information processing insight male new technology programs psychosocial research study response risk perception statistics theories therapy design

项目摘要

DESCRIPTION (provided by applicant): The overall goal of this career award proposal is to enable Dr. Wang to become an independent investigator n the design of interventions to communicate messages about genetic and environmental risk, with a focus on colorectal cancer. The effective communication of genetic and environmental risk factor information has grown increasingly important as advances in genetic technology continue to shed new light on their contributions to colorectal cancer risk. To date, little is known about how best to communicate risk factor information to increase behavioral motivation, thus limiting the application of these new technologies for public health benefit. The impact of communication about cancer risk factors depends, in part, on the prior beliefs and cognitive representations held about the disease feedback being conveyed. In particular, causal attributions - the beliefs people have about the causes of colorectal cancer - are an important, but understudied, determinant of whether and to what extent individuals take behavioral action to reduce the likelihood of developing the disease. A better understanding of causal attributions for colorectal cancer among the general population is essential in order to systematically and comprehensively delineate how people think about the causes of cancer, and identify those attributions that facilitate, or undermine, screening adherence and lifestyle change. Using a combination of survey and experimental research methodologies, two studies are being proposed that build on each other in logical sequence to 1) describe the nature of causal attributions for colorectal cancer and their association with screening and lifestyle behaviors, and 2) begin to experimentally test the impact of genetic and environmentally-focused risk communication messages on patterns of causal attributions and health behaviors among unaffected individuals. The training plan proposed supports this research by providing the necessary advanced mentoring and coursework in communication science, psychometric methods, intervention strategies, and advanced statistics. This will enable the PI to effectively conduct the studies and prepare her for an R01 submission in year 5, building on the findings obtained to create more refined messages for colorectal screening and prevention. This synergistic program of training and research will be essential to understanding how individuals respond to risk communication messages for colorectal cancer, as well as other cancer sites. Perhaps most importantly, the knowledge gained from these studies will be critical to inform the development and evaluation of theory-guided tailored interventions that focus on conveying genetic and/or environmental risk information to the general population in efforts to promote behavior change and, ultimately, public health benefits.

描述（由申请人提供）：该职业奖励建议的总体目标是使Wang博士成为独立的研究者，并设计了干预措施，以传达有关遗传和环境风险的信息，重点是结直肠癌。随着遗传技术的进步继续为结直肠癌风险贡献，遗传和环境风险因素信息的有效沟通变得越来越重要。迄今为止，知之甚少，如何最好地传达风险因素信息以增加行为动机，从而限制了这些新技术以实现公共卫生利益。关于癌症风险因素的交流的影响部分取决于先前关于疾病反馈所传达的信念和认知表达。特别是，因果归因 - 人们对结直肠癌的原因的信念 - 是一个重要但有研究的，决定了个人是否以及在何种程度上采取行为行动来减少发展疾病的可能性。为了系统地和全面地描述人们如何看待癌症的原因，并确定促进或破坏筛查依从性和生活方式的改变，对普通人群中大种群中结直肠癌的因果归因的理解至关重要。 Using a combination of survey and experimental research methodologies, two studies are being proposed that build on each other in logical sequence to 1) describe the nature of causal attributions for colorectal cancer and their association with screening and lifestyle behaviors, and 2) begin to experimentally test the impact of genetic and environmentally-focused risk communication messages on patterns of causal attributions and health behaviors among unaffected individuals.培训计划提出的培训计划通过提供传播科学，心理测量方法，干预策略和高级统计的必要高级指导和课程来支持这项研究。这将使PI能够有效地进行研究，并在第五年为R01提交做好准备，这是基于获得的发现，目的是为结直肠筛查和预防创建更精致的消息。这项协同的培训和研究计划对于了解个人如何应对结直肠癌以及其他癌症部位的风险交流信息至关重要。也许最重要的是，从这些研究中获得的知识将至关重要，对于理论指导的量身定制干预措施的发展和评估，这些干预措施着重于将遗传和/或环境风险信息传达给普通人群，以促进行为改变，并最终获得公共卫生的利益。