Using PET to Image the Neurochemistry of Addiction

使用 PET 对成瘾的神经化学进行成像

• 批准号: 7886869
• 负责人: Diana M Martinez
• 金额: $ 12.37万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7886869
• 关键词: Alcohols; Asses; Award; Brain; Clinical; Clinical Research; Cocaine; Cocaine Dependence; Collaborations; Control Groups; Development; Disease; Dopamine; Dopamine Receptor; Drug Addiction; Exposure to; Heroin Dependence; Image; Independent Scientist Award; Individual; Measures; Mentored Patient-Oriented Research Career Development Award; Modeling; Neurotensin Receptors; Neurotransmitters; Pathology; Pharmaceutical Preparations; Play; Population; Positron-Emission Tomography; Relapse; Research; Research Personnel; Role; Substance abuse problem; System; Time; Work; addiction; career; drug of abuse; human subject; neurochemistry; nonhuman primate; preclinical study; programs; public health relevance; radioligand; receptor binding; transmission process

DESCRIPTION (provided by applicant): Previous clinical and pre-clinical studies have shown that the dysregulation in dopamine transmission plays a critical role in substance abuse. The studies presented in this application include the candidate's work characterizing the alteration in dopamine transmission seen in addiction. These studies include research done in cocaine, alcohol, and heroin dependence, and show that each of these disorders is associated with a loss of D2/3 receptor binding and pre-synaptic dopamine transmission. Importantly, the work done in cocaine dependence shows that dopamine transmission is predictive of relapse. The next step is to explore the mechanisms that contribute to dopamine dysregulation in addition to studying other neurotransmitter systems that directly regulate dopamine transmission. These studies include imaging micriglial activation, in addition to the kappa and neurotensin receptors systems. The candidate developed her PET imaging career through the K23 award mechanism. Due to the support provided by that award, she was able to pursue a career in imaging studies in substance dependent populations. As an independent researcher, the candidate has continued this line of work. In addition, the candidate has pursued numerous collaborations in an effort to bring PET radioligand imaging into more types of clinical research. This application for a K02 award will allow the candidate's career to continue uninterrupted as she pursues new directions in PET imaging. PUBLIC HEALTH RELEVANCE: Previous work performed by the applicant for this award have shown that dopamine is involved in drug addiction. The next set of studies will examine the cause of the changes in brain dopamine and ways to correct this deficit.

描述（由申请人提供）：以前的临床和临床前研究表明，多巴胺传播的失调在药物滥用中起着至关重要的作用。本申请中介绍的研究包括候选人的工作，表征了成瘾中多巴胺传播的改变。这些研究包括在可卡因，酒精和海洛因依赖性方面进行的研究，并表明这些疾病中的每一种都与D2/3受体结合和突触前多巴胺传播的丧失有关。重要的是，可卡因依赖性所做的工作表明多巴胺的传播是复发的预测。下一步是探索除了研究直接调节多巴胺传播的其他神​​经递质系统外，还导致多巴胺失调的机制。这些研究还包括成像小体激活，除了KAPPA和神经素受体系统。候选人通过K23奖项机制发展了她的宠物成像事业。由于该奖项提供的支持，她能够从事依赖物质人群的成像研究职业。作为一名独立研究人员，候选人继续进行这项工作。此外，候选人已经进行了许多合作，以将PET放射性成像带入更多类型的临床研究中。这项K02奖项的申请将使候选人的职业生涯在追求宠物成像的新方向时继续不间断。 公共卫生相关性：该奖项申请人以前的工作表明多巴胺参与吸毒。下一组研究将研究脑多巴胺变化的原因以及纠正这种赤字的方法。