Psychogenetic Factors in Project REACH

REACH 项目中的心理因素

• 批准号: 7886804
• 负责人: NICOLE R NUGENT
• 金额: $ 16.2万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7886804
• 关键词: Adherence; Adolescent; Anti-Retroviral Agents; Anxiety; Attenuated; Behavior; Behavioral; Brain-Derived Neurotrophic Factor; CD8-Positive T-Lymphocytes; CD8B1 gene; Collaborations; DRD4 gene; Data; Development; Disease Progression; Drug resistance; Educational workshop; Ethics; Failure; Familiarity; Future; Genes; Genetic; Genetic Research; Goals; HIV; HIV-1; Health; Health behavior; Healthcare; Human; Infection; Interdisciplinary Study; Intervention; K-Series Research Career Programs; Level of Evidence; Life; Mediating; Mental Depression; Mentored Research Scientist Development Award; Mentors; Mentorship; Modeling; Molecular Genetics; Natural Killer Cells; Neurobiology; Outcome; Participant; Pathway interactions; Patients; Pattern; Plasma; Population; Process; RNA; Regimen; Research; Research Training; Risk; Risk Behaviors; Sampling; Scientist; Social support; Solid; Statistical Models; Substance abuse problem; Symptoms; Thick; Training; Variant; Viral Load result; Youth; antiretroviral therapy; career; compliance behavior; cost; cytokine; depressive symptoms; experience; genetic variant; health related quality of life; innovation; medication compliance; psychogenetics; public health relevance; resistant strain; sex; sex risk; stressor; transmission process

DESCRIPTION (provided by applicant): The submitted application for a K01 Mentored Scientist Career Development Award will afford Dr. Nicole Nugent formal and tailored training essential for her programmatic line of research in genetic predictors of psychiatric functioning (e.g., depression, anxiety, substance abuse), health behaviors (e.g., medication adherence, sex risk), and health outcomes (e.g., CD4/CD8 lymphocytes, HIV-1 plasma RNA levels, cytokines, and natural killer cells) in youth living with HIV (YLH). Given that YLH evidence levels of non- adherence to antiretroviral regimens expected to result in drug resistance and virologic failure, thereby increasing likelihood of transmission of drug-resistant strains to others, the public and patient health relevance elucidating factors that may influence health behaviors is substantial. Select genetic variants may influence patient health outcomes via their effects on synergistic neurobiological and psychobehavioral processes. Genetic samples and longitudinal data collected through the Reaching for Excellence in Adolescent Care and Health (REACH) Project provide a unique, cost-effective opportunity to examine these aims. Additionally, the proposed research is ideally suited to Dr. Nugent's career and training goals to: (1) obtain sufficient training in molecular genetics to permit informed multidisciplinary research collaborations with molecular genetics and other scientists, (2) gain expertise in advanced statistical modeling of genetic variants influencing human behavior and psychiatric conditions, (3) obtain familiarity with genetic influences on HIV transmission and post-infection disease progression, (4) further sensitivity to ethical considerations in genetic research and research with stigmatized populations, and to establish herself as a contributor within the psychiatric genetic and adolescent HIV scientific fields. These training goals will be achieved through a combination of formal coursework and workshops, applied training experiences using REACH and mentor data, and ongoing close mentorship. This K01 award will permit training and research findings to support future planned ROIs and programmatic line of innovative research with YLH. PUBLIC HEALTH RELEVANCE: Although antiretroviral therapy has afforded marked health gains in YLH, these benefits are limited by patient adherence. Non-adherence results in emergence of drug-resistant strains of HIV. Identification of factors that may contribute to health outcomes in YLH via their effects on psychobehavioral and/or neurobiological processes will permit the development of informed behavioral and pharmacologic interventions for YLH.

DESCRIPTION (provided by applicant): The submitted application for a K01 Mentored Scientist Career Development Award will afford Dr. Nicole Nugent formal and tailored training essential for her programmatic line of research in genetic predictors of psychiatric functioning (e.g., depression, anxiety, substance abuse), health behaviors (e.g., medication adherence, sex risk), and health outcomes (e.g., CD4/CD8 lymphocytes, HIV-1艾滋病毒（YLH）青年中的血浆RNA水平，细胞因子和天然杀伤细胞）。鉴于YLH对抗逆转录病毒方案的不遵守的证据水平预计预计会导致耐药性和病毒学衰竭，从而增加了向其他人传播抗药性菌株的可能性，公众和患者的健康相关因素可能会影响健康行为。选择的遗传变异可能会通过对协同神经生物学和心理狂行过程的影响来影响患者的健康结果。通过达到青少年护理和健康（覆盖范围）项目的卓越范围收集的遗传样本和纵向数据为检查这些目标提供了独特的，具有成本效益的机会。此外，拟议的研究非常适合Nugent博士的职业和培训目标：（1）获得足够的分子遗传学培训，可以允许与分子遗传学和其他科学家的知情多学科研究合作，（2）在影响人类行为和精神上的疾病方面的遗传变异方面的高级统计模型（3）获得概念的统计模型（3） （4）对遗传研究和研究的道德考虑的进一步敏感性，并以污名化的人群为生，并在精神遗传和青少年艾滋病毒科学领域中成为贡献者。这些培训目标将通过正式的课程和讲习班，使用Reach和指导数据的应用培训经验以及持续的近距离指导来实现。该K01奖将允许培训和研究结果，以支持未来计划的ROI和YLH的创新研究计划。公共卫生相关性：尽管抗逆转录病毒疗法在YLH方面具有明显的健康增长，但这些好处受患者依从性的限制。不遵守导致抗毒抗菌菌株的出现。鉴定可能通过对YLH对心理行为和/或神经生物学过程的影响而导致健康结果的因素将允许开发YLH的知情行为和药理干预措施。