Fast-Track:Biomagnetic In-vivo Imaging of Ovarian Cancer

快速通道：卵巢癌生物磁体内成像

• 批准号: 7780637
• 负责人: EDWARD R FLYNN
• 金额: $ 37.17万
• 依托单位: SENIOR SCIENTIFIC
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7780637
• 关键词: Antibodies; Antineoplastic Agents; Austria; Biochemical; Biological; Biology; Biopsy; Cancerous; Cell Count; Cell Line; Cells; Characteristics; Contrast Media; Cytometry; Data; Detection; Development; Diagnosis; Disease; Early Diagnosis; Goals; Graft Rejection; Histology; Image; Injection of therapeutic agent; International; Label; Lead; Lesion; Life; Lipids; Location; Magnetic Resonance Imaging; Magnetism; Malignant neoplasm of ovary; Measurement; Measures; Medicine; Methodology; Methods; Modeling; Monitor; Nanotechnology; Noise; Ovarian; Ovary; Patients; Pharmaceutical Preparations; Phase; Physics; Physiologic pulse; Premalignant; Property; Publishing; Radiation; Research; Sampling; Screening procedure; Sensitivity and Specificity; Serum; Signal Transduction; Site; Source; Spatial Distribution; Squid; Staging; Structure; System; Techniques; Ultrasonography; Urine; angiogenesis; cancer site; cancer therapy; cancer type; clinical application; design; follow-up; human tissue; improved; in vivo; magnetic field; malignant breast neoplasm; mouse model; nanobiotechnology; nanoparticle; ovarian neoplasm; overexpression; particle; programs; research study; sensor; small molecule; success; symposium; targeted delivery; theories; tumor

DESCRIPTION (provided by applicant): A novel method for applying nanotechnology to the early detection, localization and potential treatment of ovarian cancer has been developed. Recent measurements, using live ovarian cancer cell lines and the ovarian cancer marker CA-125, have shown that the sensitivity of this method is better than 105 cells at depths of 5 - 8 cm from the sensor. This is significantly more sensitive than the 108 cells required for ultrasound or x-ray imaging. Sensitive biomagnetic sensors are used to measure the remanence fields of superparamagnetic nanoparticles conjugated with specific markers for ovarian cancer cells or pre-cancerous lesions. Measurements indicate that 104 nanoparticles attach to each cancer cell yielding a high magnetic moment/cell. An array of SQUID sensors are used to detect and localize these superparamagnetic nanoparticles. In order to develop protocols for clinical trials, experiments are proposed using nanoparticles, labeled with several ovarian markers, injected into phantom ovaries, ovarian tissue, and extracted human ovaries. Following this, multicomponent nanoparticles, containing both marker and anti-cancer molecules will be investigated for cancer destruction using magnetic concentration. In subsequent clinical applications, labeled-magnetic nanoparticles will be injected into the patient using the procedures developed in these studies.

描述（由申请人提供）：已开发了一种将纳米技术应用于早期发现，定位和潜在治疗卵巢癌的新方法。使用活卵巢癌细胞系和卵巢癌标记CA -125的最新测量表明，该方法的敏感性优于105个细胞，在离传感器5-8 cm的深度下。这比超声或X射线成像所需的108个细胞更敏感。敏感的生物磁传感器用于测量与卵巢癌细胞或癌细胞病变特异性标记的超顺磁性纳米颗粒的re漫画场。测量表明，104个纳米颗粒附着于每个癌细胞，产生高磁矩/细胞。一系列鱿鱼传感器用于检测和定位这些超磁纳米颗粒。为了制定用于临床试验的方案，使用纳米颗粒提出了实验，并标记了几个卵巢标记物，并注入了幻影卵巢，卵巢组织和提取的人类卵巢。此后，将研究使用磁浓度的多组分纳米颗粒，这些纳米颗粒均包含标记物和抗癌分子的癌症破坏。在随后的临床应用中，使用这些研究中开发的程序将标记的磁性纳米颗粒注入患者。