PET/CT for Multidimensional Translational Cardiovascular Research

PET/CT 用于多维转化心血管研究

• 批准号: 7498749
• 负责人: John M Canty
• 金额: $ 200万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7498749
• 关键词: Animal Disease Models; Animal Model; Area; Arts; Award; Blood Vessels; Buffaloes; Cardiac; Cardiomyopathies; Cardiovascular system; Cause of Death; Chronic; Clinical; Clinical Trials; Coronary heart disease; Coupled; Cyclotrons; Disease; Evaluation; Event; Family suidae; Gene Transfer; Health; Heart; Heart Diseases; Human; Hybrids; Image; Image Analysis; K-Series Research Career Programs; Medicine; Mesenchymal Stem Cells; Modeling; Myocardial; Myocardial Ischemia; Myocardium; Outcome; Patient Care; Patients; Positron-Emission Tomography; Radiochemistry; Radiopharmaceuticals; Request for Proposals; Research; Risk; Stem cells; Stents; Stroke; Structure; System; Therapeutic; Time; Tomography, Computed, Scanners; Tracer; Translational Research; Translations; United States National Institutes of Health; Universities; Vascular Diseases; X-Ray Computed Tomography; bench to bedside; cardiovascular imaging; clinically relevant; disability; dosimetry; improved; in vivo; instrument; molecular imaging; mouse model; nerve supply; novel; patient oriented research; pre-clinical; preclinical study; programs; public health relevance; repaired; sudden cardiac death

DESCRIPTION (provided by applicant): Cardiovascular molecular imaging is a rapidly emerging area offering considerable promise for the evaluation of patients with heart and vascular disease. While proof of concept studies using novel imaging agents and micro PET have been conducted in mouse models of heart disease, their translation to humans and large animal models has been problematic since the human heart is 2000 times larger and dosimetry and tracer localization are considerably different. This proposal requests support to advance preclinical and clinical translational cardiovascular molecular imaging by acquiring a hybrid positron emission tomography (PET) and multidetector computed tomography (CT) scanner dedicated to research. It will support and enhance the ongoing investigational imaging programs of seven major users (supported by 9 RO1 awards and 2 K awards focused on cardiovascular imaging). The proposed GE Discovery VCT is a state of the art PET/CT scanner that will permit preclinical studies of vascular and myocardial structure coupled with molecular imaging using novel cyclotron generated radiopharmaceuticals developed at the adjacent UB Center for Positron Emission Tomography. The Center for Research in Cardiovascular Medicine and Toshiba Stroke Center at the University at Buffalo are interdisciplinary cardiovascular research centers that are recognized leaders in translational cardiovascular imaging. NIH supported studies routinely employ advanced cardiovascular imaging in porcine models of chronic ischemic heart disease and large animal models of stroke. Besides basic mechanistic research, active programs exist in therapeutics including vascular stents, in vivo gene transfer and cardiovascular repair with stem cells (mesenchymal stem cells and endothelial progenitor cells). There is also a large ongoing NIH supported clinical trial to determine if PET can predict the risk of sudden cardiac death in patients by quantifying the extent of hibernating myocardium and imaging inhomogeneity in sympathetic innervation using 11C-Hydroxyephedrine (Prediction of Arrhythmic Events with Positron Emission Tomography). The combined institutional expertise in large animal disease models including hibernating myocardium, coronary disease, cerebrovasular disease and ischemic cardiomyopathy along with patient oriented research in cardiac PET, quantitative image analysis and radiochemistry synthesis are unique strengths of this investigative team. The proposed instrument and synergy between these two teams will facilitate rapid advancements in the field of molecular imaging as applied to the cardiovascular system. PUBLIC HEALTH RELEVANCE: Heart disease continues to be one of the leading causes of death and disability. The proposed PET/CT system will advance bench to bedside research of potentially clinically relevant therapies by focusing on research at the preclinical to clinical translational interface. Such multilevel translational research ultimately has a high likelihood of directly impacting patient care and improving health outcomes. `

描述（由申请人提供）：心血管分子成像是一个快速新兴的领域，为评估心脏和血管疾病患者提供了广阔的前景。虽然使用新型显像剂和微型 PET 的概念验证研究已在小鼠心脏病模型中进行，但将其转化为人类和大型动物模型一直存在问题，因为人类心脏比人类心脏大 2000 倍，并且剂量测定和示踪剂定位存在很大差异。该提案要求通过获取专用于研究的混合正电子发射断层扫描（PET）和多探测器计算机断层扫描（CT）扫描仪来支持推进临床前和临床转化心血管分子成像。它将支持和加强七个主要用户正在进行的研究性成像项目（由专注于心血管成像的 9 个 RO1 奖项和 2 K 奖项支持）。拟议的 GE Discovery VCT 是一种最先进的 PET/CT 扫描仪，可利用邻近布法罗大学正电子发射断层扫描中心开发的新型回旋加速器产生的放射性药物，对血管和心肌结构进行临床前研究，并结合分子成像。布法罗大学心血管医学研究中心和东芝中风中心是跨学科心血管研究中心，是转化心血管成像领域公认的领导者。美国国立卫生研究院支持的研究通常在慢性缺血性心脏病的猪模型和中风的大型动物模型中采用先进的心血管成像。除了基础机制研究外，治疗学方面也存在活跃的项目，包括血管支架、体内基因转移和干细胞（间充质干细胞和内皮祖细胞）心血管修复。还有一项 NIH 支持的大型临床试验正在进行，以确定 PET 是否可以通过量化冬眠心肌的范围和使用 11C-羟基麻黄碱对交感神经支配成像的不均匀性来预测患者心源性猝死的风险（使用正电子发射断层扫描预测心律失常事件） ）。大型动物疾病模型（包括冬眠心肌、冠心病、脑血管疾病和缺血性心肌病）的综合专业知识以及以患者为导向的心脏 PET、定量图像分析和放射化学合成研究是该研究团队的独特优势。拟议的仪器和这两个团队之间的协同作用将促进应用于心血管系统的分子成像领域的快速发展。 公共卫生相关性：心脏病仍然是死亡和残疾的主要原因之一。拟议的 PET/CT 系统将重点关注临床前到临床转化界面的研究，从而推进潜在临床相关疗法的实验室到临床研究。这种多层次的转化研究最终很可能直接影响患者护理和改善健康结果。 `