PET/CT for Multidimensional Translational Cardiovascular Research

PET/CT 用于多维转化心血管研究

• 批准号: 7498749
• 负责人: John M Canty
• 金额: $ 200万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7498749
• 关键词: Animal Disease Models; Animal Model; Area; Arts; Award; Blood Vessels; Buffaloes; Cardiac; Cardiomyopathies; Cardiovascular system; Cause of Death; Chronic; Clinical; Clinical Trials; Coronary heart disease; Coupled; Cyclotrons; Disease; Evaluation; Event; Family suidae; Gene Transfer; Health; Heart; Heart Diseases; Human; Hybrids; Image; Image Analysis; K-Series Research Career Programs; Medicine; Mesenchymal Stem Cells; Modeling; Myocardial; Myocardial Ischemia; Myocardium; Outcome; Patient Care; Patients; Positron-Emission Tomography; Radiochemistry; Radiopharmaceuticals; Request for Proposals; Research; Risk; Stem cells; Stents; Stroke; Structure; System; Therapeutic; Time; Tomography, Computed, Scanners; Tracer; Translational Research; Translations; United States National Institutes of Health; Universities; Vascular Diseases; X-Ray Computed Tomography; bench to bedside; cardiovascular imaging; clinically relevant; disability; dosimetry; improved; in vivo; instrument; molecular imaging; mouse model; nerve supply; novel; patient oriented research; pre-clinical; preclinical study; programs; public health relevance; repaired; sudden cardiac death

DESCRIPTION (provided by applicant): Cardiovascular molecular imaging is a rapidly emerging area offering considerable promise for the evaluation of patients with heart and vascular disease. While proof of concept studies using novel imaging agents and micro PET have been conducted in mouse models of heart disease, their translation to humans and large animal models has been problematic since the human heart is 2000 times larger and dosimetry and tracer localization are considerably different. This proposal requests support to advance preclinical and clinical translational cardiovascular molecular imaging by acquiring a hybrid positron emission tomography (PET) and multidetector computed tomography (CT) scanner dedicated to research. It will support and enhance the ongoing investigational imaging programs of seven major users (supported by 9 RO1 awards and 2 K awards focused on cardiovascular imaging). The proposed GE Discovery VCT is a state of the art PET/CT scanner that will permit preclinical studies of vascular and myocardial structure coupled with molecular imaging using novel cyclotron generated radiopharmaceuticals developed at the adjacent UB Center for Positron Emission Tomography. The Center for Research in Cardiovascular Medicine and Toshiba Stroke Center at the University at Buffalo are interdisciplinary cardiovascular research centers that are recognized leaders in translational cardiovascular imaging. NIH supported studies routinely employ advanced cardiovascular imaging in porcine models of chronic ischemic heart disease and large animal models of stroke. Besides basic mechanistic research, active programs exist in therapeutics including vascular stents, in vivo gene transfer and cardiovascular repair with stem cells (mesenchymal stem cells and endothelial progenitor cells). There is also a large ongoing NIH supported clinical trial to determine if PET can predict the risk of sudden cardiac death in patients by quantifying the extent of hibernating myocardium and imaging inhomogeneity in sympathetic innervation using 11C-Hydroxyephedrine (Prediction of Arrhythmic Events with Positron Emission Tomography). The combined institutional expertise in large animal disease models including hibernating myocardium, coronary disease, cerebrovasular disease and ischemic cardiomyopathy along with patient oriented research in cardiac PET, quantitative image analysis and radiochemistry synthesis are unique strengths of this investigative team. The proposed instrument and synergy between these two teams will facilitate rapid advancements in the field of molecular imaging as applied to the cardiovascular system. PUBLIC HEALTH RELEVANCE: Heart disease continues to be one of the leading causes of death and disability. The proposed PET/CT system will advance bench to bedside research of potentially clinically relevant therapies by focusing on research at the preclinical to clinical translational interface. Such multilevel translational research ultimately has a high likelihood of directly impacting patient care and improving health outcomes. `

描述（由申请人提供）：心血管分子成像是一个快速新兴区域，为评估心脏和血管疾病患者评估提供了相当大的希望。虽然在心脏病的小鼠模型中已经进行了使用新型成像剂和微PET的概念证明研究，但它们的翻译为人类和大型动物模型一直存在问题，因为人类心脏的重量是2000倍，而剂量测定和示踪剂定位却大不相同。该提案要求通过获取专门用于研究的杂化正电子发射断层扫描（PET）和多探测器计算机层析成像（CT）扫描仪来推动临床前和临床转化心血管分子成像。它将支持并增强七个主要用户的正在进行的研究成像计划（由9个RO1奖项和2 K奖项支持，重点介绍了心血管成像）。拟议的GE Discovery VCT是一种最先进的PET/CT扫描仪的状态，它将允许使用新型的Cyclotron生成的放射性药物在邻接的UB Potitron发射器中心发出的新型循环加成子制作的放射性药物进行临床前研究以及分子成像。布法罗大学的心血管医学研究中心和东芝卒中中心是跨学科的心血管研究中心，这些中心是转化心血管成像领域的公认领导者。 NIH支持的研究通常在慢性缺血性心脏病和大型中风动物模型的猪模型中使用晚期心血管成像。除了基本的机械研究外，在包括血管支架，体内基因转移以及干细胞（间充质干细胞和内皮祖细胞）的治疗方法中还存在活性程序。还有一项大型正在进行的NIH支持的临床试验，以确定PET是否可以通过使用11C-羟基甲氨ine（通过正电子发射构象对心律失常事件的预测）来量化患者的心脏死亡的风险。大型动物疾病模型中的合并机构专业知识，包括冬眠心肌，冠状动脉疾病，脑脑疾病和缺血性心肌病以及心脏PET的患者研究，定量图像分析和放射化学合成是该研究团队的独特优势。这两个团队之间提出的仪器和协同作用将促进用于心血管系统的分子成像领域的快速发展。 公共卫生相关性：心脏病仍然是死亡和残疾的主要原因之一。拟议的PET/CT系统将通过专注于临床前至临床翻译界面的研究来提高基准研究潜在临床相关疗法的床边研究。这样的多级翻译研究最终具有直接影响患者护理和改善健康结果的很有可能性。 `