SPHARM Shape Modeling and Analysis Toolkit for Brain Imaging

用于脑成像的 SPHARM 形状建模和分析工具包

基本信息

批准号：
7852070
负责人：
LI SHEN
金额：
$ 1.89万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-11 至 2009-10-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This R03 application is for one year of funding to develop and release SPHARM-MAT, a 3D shape modeling and analysis toolkit for neuroanatomical studies. Shape analysis is becoming of increasing interest to the neuroimaging community because of its potential to provide important information beyond simple volume measurements. SPHARM-MAT is a suite of tools that are designed to effectively characterize and normalize morphometric features of 3D brain structures using spherical harmonic functions (SPHARM). It establishes a foundation on which statistical shape analysis can be performed to discover morphometric changes in neuroanatomical structures related to specific brain disorders. The development of SPHARM-MAT is a synergistic effort in relation to existing tools. It provides an alternative software platform as well as an opportunity for tool comparison and cross-validation. More importantly, it is a powerful toolkit with several new features that add value. It has a broader applicability due to the implementation of several new algorithms that overcome the limitations of the traditional SPHARM method. It is user-friendly and interoperable, offering a graphical interface, modular design structure, and well-documented user manual and source code. The objectives of this research include (1) implementing an improved method for individual SPHARM modeling, (2) implementing an improved method for group analysis using SPHARM, and (3) packaging this functionality together with other necessary components in SPHARM-MAT and releasing the toolkit. SPHARM-MAT will be developed by packaging the existing prototype implementation of SPHARM processing components from previous studies as well as by implementing additional necessary components including a graphical user interface, a visualization module, a user manual, a project wiki site, and documentation of source code. SPHARM-MAT will be released at NITRC (www.nitrc.org) using GNU General Public License for wide dissemination. The dissemination of this new toolkit will enable investigators working on many brain disorders to more effectively test neuroanatomical hypotheses and therefore this project will benefit public health outcomes. PUBLIC HEALTH RELEVANCE: Shape analysis is becoming of increasing interest to the neuroimaging community because of its potential to provide important information beyond simple volume measurements and to understand morphometric changes in neuroanatomical structures related to specific brain disorders. The purpose of this project is to develop and release SPHARM-MAT, a 3D shape modeling and analysis toolkit for neuroanatomical studies. SPHARM-MAT is a synergistic effort in relation to existing tools, and is a powerful toolkit with several new features that add value, including ease of use, broad applicability, good interoperability, and wide dissemination.

描述（由申请人提供）：此 R03 申请提供一年的资助，用于开发和发布 SPHARM-MAT，这是一种用于神经解剖学研究的 3D 形状建模和分析工具包。形状分析越来越受到神经影像学界的关注，因为它有可能提供简单体积测量之外的重要信息。 SPHARM-MAT 是一套工具，旨在使用球谐函数 (SPHARM) 有效地表征和标准化 3D 大脑结构的形态特征。它建立了一个基础，在此基础上可以进行统计形状分析，以发现与特定脑部疾病相关的神经解剖结构的形态变化。 SPHARM-MAT 的开发是与现有工具的协同努力。它提供了替代软件平台以及工具比较和交叉验证的机会。更重要的是，它是一个功能强大的工具包，具有多项增值新功能。由于多种新算法的实现克服了传统SPHARM方法的局限性，因此它具有更广泛的适用性。它用户友好且可互操作，提供图形界面、模块化设计结构以及详细记录的用户手册和源代码。本研究的目标包括 (1) 实现一种改进的个体 SPHARM 建模方法，(2) 实现一种改进的使用 SPHARM 进行组分析的方法，以及 (3) 将此功能与 SPHARM-MAT 中的其他必要组件打包在一起，并发布工具包。 SPHARM-MAT 将通过打包先前研究中的 SPHARM 处理组件的现有原型实现以及实现其他必要组件（包括图形用户界面、可视化模块、用户手册、项目 wiki 站点和源文档）来开发代码。 SPHARM-MAT 将使用 GNU 通用公共许可证在 NITRC (www.nitrc.org) 上发布，以进行广泛传播。这个新工具包的传播将使研究许多脑部疾病的研究人员能够更有效地测试神经解剖学假设，因此该项目将有利于公共卫生结果。公共健康相关性：形状分析越来越受到神经影像学界的关注，因为它不仅可以提供简单体积测量之外的重要信息，还可以了解与特定脑部疾病相关的神经解剖结构的形态变化。该项目的目的是开发和发布 SPHARM-MAT，这是一个用于神经解剖学研究的 3D 形状建模和分析工具包。 SPHARM-MAT 是与现有工具的协同工作，是一个功能强大的工具包，具有多种增值新功能，包括易用性、广泛的适用性、良好的互操作性和广泛的传播。