Precision Rehabilitation Research for Children with Neuromotor Conditions (APTA Academy of Pediatric Physical Therapy Research Summit 6)

神经运动疾病儿童精准康复研究（APTA儿科物理治疗学会研究峰会第六届）

• 批准号: 10754016
• 负责人: Jessica M Cassidy
• 金额: $ 1.5万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-05 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10754016
• 关键词: Academy; Address; Age; American Physical Therapy Association; Applications Grants; Area; Award; Biological Factors; Caregivers; Caring; Cerebral Palsy; Child; Child Development; Childhood; Clinic; Collaborations; Communities; Complement; Complex; Databases; Dedications; Development; Discipline; Engineering; Ensure; Environment; Environmental Risk Factor; Epigenetic Process; Equity; Family; Fostering; Foundations; Funding; Genes; Genetic; Genomics; Grant; Growth; Health system; Healthcare; Hour; Impairment; Individual; Individual Differences; Infrastructure; Injury; Institution; Intervention; Knowledge; Laboratories; Life Style; Longevity; Measurement; Medical; Minority Groups; Modeling; National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; Neurosciences; Outcome; Outcomes Research; Parents; Participant; Patients; Pediatric Research; Pediatrics; Physical Rehabilitation; Physical therapy; Process; Psychosocial Factor; Public Health Informatics; Qualifying; Recording of previous events; Rehabilitation therapy; Research; Research Design; Research Methodology; Research Personnel; Research Priority; Research Project Grants; Research Support; Scholarship; Science; Scientist; Source; Standardization; Strategic Planning; Subgroup; Tea; Techniques; Technology; Terminology; Testing; Therapeutic Studies; Time; Translational Research; Translations; Treatment Protocols; United States National Institutes of Health; career; cohort; contextual factors; disability; functional restoration; improved; individual variation; innovation; lectures; meetings; member; novel; personalized approach; precision medicine; programs; rehabilitation research; rehabilitative care; social; social health determinants; student participation; success; symposium

ABSTRACT The need for rehabilitation in children is immense, with figures suggesting that 3.3 million US children have an ongoing need for rehabilitation therapy, 1.1 million have persistent mobility impairments, and an additional 1 million need rehabilitation to restore function after injury. Our ability to generate evidence from the traditional iterative trial and error process of rehabilitation (evaluate–treat–re-evaluate–adjust) has been complicated by inconsistency in the selection of outcomes and treatment regimens across patients, and not surprisingly, has led to wide variability in outcomes. Implementation of precision-medicine to physical rehabilitation moves away from both “one-size-fits-all” and trial-and-error approaches to therapy and instead embraces a personalized approach by considering genetic and epigenetic influences and social determinants of health to match “the right intervention, at the right time, to the right individual.” This conference grant proposal seeks support for the Research Summit 6 (RS6) meeting of the American Physical Therapy Association Academy of Pediatrics (APTA Pediatrics), “Precision Rehabilitation Research for Children with Neuromotor Conditions.” Spanning an intensive 1-full and 2-half day period, RS6 will be the first conference in pediatric physical rehabilitation dedicated to precision rehabilitation. It will leverage the strong record of success of APTA Pediatrics' previous five research summits that have resulted in over $15 million in subsequent funding to date from federal and foundation sources. Critical to the implementation of a precision medicine approach to pediatric physical rehabilitation is representation of a diverse cohort of scientists, clinicians, and parents/children. The RS6 meeting will include interdisciplinary lectures, a keynote address, caregiver/consumer and sponsorship/funding panels, large and small group discussions, and unique networking opportunities to achieve our proposed aims of [1] providing interdisciplinary and didactic content to support the translation of precision medicine to pediatric physical rehabilitation, [2] identifying current gaps in knowledge and critical research challenges necessary to advance pediatric precision rehabilitation, and [3] fostering growth of pediatric precision rehabilitation research. Funds from this award will complement monetary support already procured from APTA Pediatrics that will fund the essentials of the meeting and up to 4 subsequent pilot/planning research grants submitted by RS6 participants. Supplemental support is requested from NICHD and NINDS which will ensure diversity in both RS6 content and attendance, including supporting additional speakers and providing stipends to support participation from students who identify as a member of a minority group or subgroup. In addition to cultivating novel collaborations in pediatric precision rehabilitation, the main outcomes of RS6 are to develop a replicable model of precision rehabilitation over the lifespan and impart a common set of terminology among disciplines.

抽象的 儿童康复的需求巨大，有数据表明，330 万美国儿童患有康复疾病。 持续需要康复治疗，110 万人患有持续性行动障碍，另有 1 人 百万康复需要在受伤后恢复功能 我们从传统中产生证据的能力。 康复的迭代试错过程（评估-治疗-重新评估-调整）变得复杂 患者之间的结果和治疗方案的选择不一致，这并不奇怪，导致了 精准医疗的实施与身体康复的结果存在很大差异。 “一刀切”和反复试验的治疗方法，而是采用个性化方法 通过考虑遗传和表观遗传影响以及健康的社会决定因素来匹配“正确的 在正确的时间对正确的个人进行干预。”该会议拨款提案寻求支持 美国物理治疗协会儿科学会 (APTA) 研究峰会 6 (RS6) 会议 儿科），“神经运动疾病儿童的精准康复研究”。 为期 1 天和 2 个半天的会议，RS6 将是第一个专门针对儿科物理康复的会议 它将利用 APTA Pediatrics 之前五项研究的成功记录。 迄今已从联邦和基金会获得超过 1500 万美元的后续资金 实施儿科身体康复精准医学方法的关键是。 RS6 会议将包括来自不同群体的科学家、信徒和家长/儿童的代表。 跨学科讲座、主题演讲、护理人员/消费者和赞助/资助小组、大型和 小组讨论以及独特的交流机会来实现我们提出的目标 [1] 提供 跨学科和教学内容支持精准医学向儿科物理学的转化 康复，[2] 确定当前知识差距和推进所需的关键研究挑战 儿科精准康复，[3] 促进儿科精准康复研究基金的发展。 该奖项将补充 APTA 儿科已获得的资金支持，该资金将资助 会议要点以及 RS6 提交的最多 4 项后续试点/规划研究资助 NICHD 和 NINDS 请求参与者提供补充支持，以确保 RS6 的多样性。 内容和出席情况，包括支持更多演讲者并提供津贴以支持参与 除了培养小说之外，来自认同为少数群体或亚群体成员的学生。 RS6的主要成果是开发可复制的模型 整个生命周期的精准康复，并在学科之间传授一套通用的术语。