Concordance with Dietary Approaches to Stop Hypertension (DASH) diet score and health outcomes among South Asians in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study

居住在美国的南亚人动脉粥样硬化调节因素 (MASALA) 研究中南亚人的饮食评分与健康结果与控制高血压饮食方法 (DASH) 的一致性

• 批准号: 10687521
• 负责人: Bridget Murphy Hussain
• 金额: $ 0.25万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10687521
• 关键词: Abdomen; Address; Adult; Affect; Alcohol consumption; American; American Heart Association; Americas; Area; Asian; Asian Americans; Asian population; Atherosclerosis; Award; Bangladesh; Behavioral; Blood Pressure; Body Weight; Body mass index; Cardiology; Catalogs; Clinical; Clinical Practice Guideline; Cohort Studies; Communication Research; Computer software; Consumption; DASH diet; Dairy Products; Data; Data Analyses; Development; Diet; Dietary Fiber; Dietary Practices; Dietary intake; Disease; Distal; Early Diagnosis; Early Intervention; East Asian; Epidemiology; Ethnic group; Fabaceae; Faculty; Family; Fatty acid glycerol esters; Fellowship; Fiber; Food; Fostering; Foundations; Frequencies; Fruit; Future; Goals; Guidelines; Health; Health Policy; Health behavior; Hepatic; High Prevalence; Hip region structure; Hypertension; Image; India; Individual; Intake; Intervention; Investigation; Knowledge; Libraries; Longitudinal cohort study; Low Prevalence; Measurement; Measures; Mediator of activation protein; Mentorship; Modality; National Heart, Lung, and Blood Institute; Nature; Nepal; New York; Not Hispanic or Latino; Nuts; Obesity; Outcome; Pakistan; Participant; Pattern; Population; Population Group; Prevention; Primary Prevention; Processed Meats; Questionnaires; Recommendation; Research; Research Infrastructure; Research Priority; Risk Behaviors; Risk Factors; Role; Science; Services; Smoking; Smoking History; Sodium; South Asian; Sri Lanka; Statistical Data Interpretation; Students; Subgroup; Supervision; Therapeutic; Training; Training Support; United States; Universities; Vegetables; Visceral; Waist-Hip Ratio; X-Ray Computed Tomography; atherosclerosis risk; base; blood pressure reduction; cardiovascular disorder risk; clinical risk; college; computerized; coronary artery calcium; coronary calcium scoring; data harmonization; dietary; digital; disorder risk; early experience; epidemiology study; experience; follow-up; fruits and vegetables; health difference; hypertension treatment; lifestyle factors; longitudinal course; medical specialties; modifiable behavior; mortality; novel; physical inactivity; prevent; public health intervention; skills; subcutaneous; success; sugar; sweetened beverage; waist circumference

PROJECT SUMMARY/ABSTRACT South Asians are the fastest growing ethnic population group in the United States (US). Despite their increasing population presence, South Asians remain understudied and are often mis-aggregated with other ethnic subgroups. Atherosclerotic cardiovascular disease (ASCVD) is highly prevalent among South Asian Americans, yet there remains limited data on specific risk factors in this population that contribute to the longitudinal course of ASCVD and that could be modified in the prevention, early intervention, and treatment of ASCVD. Diet is an established prevention modality for ASCVD risk, with the Dietary Approaches to Stop Hypertension (DASH) dietary pattern being the recommended therapeutic diet by the National Heart, Lung, and Blood Institute (NHLBI). The NHLBI has identified eight objectives within their Research Priorities, including the investigation of factors that account for differences in health among populations (Objective 3) and optimization of therapeutic strategies to prevent, treat, and cure diseases (Objective 5). The primary goal of the proposed research is to address these objectives by analyzing data necessary to understand how concordance with the DASH dietary pattern influences ASCVD risk among South Asian Americans. This goal will be achieved by leveraging data from the Mediators of Atherosclerosis in South Asians Living in America (R01HL093009), an ongoing longitudinal cohort study of South Asian adults living in the US to: examine how DASH diet concordance is related to established ASCVD behavioral risk factors (smoking, physical inactivity, alcohol intake) (Aim 1); determine associations between DASH diet concordance and indicators of central adiposity, based on both computed tomography imaging and anthropometric measurements (Aim 2); and determine associations between DASH diet concordance and ASCVD clinical risk factors (blood pressure and the novel coronary artery calcium score) (Aim 3). The proposed research will take place at New York University (NYU), which provides access to NYU Libraries, with extensive computerized catalogs that provide digital access to most open- stack offerings; Data Services, which offer access, training, and support for specialty software packages for statistical analysis; and a robust research infrastructure that supports proposal development and fosters research engagement among NYU faculty and students. Training goals throughout the fellowship award include (1) developing and refining skills in data harmonization, management, and secondary data analysis; (2) operationalizing culturally relevant DASH dietary pattern scores adapted from food frequency questionnaires, with monthly training from the Co-Sponsor; (3) understanding the proximal and distal risk factors of ASCVD among South Asians; and (4) advancing research communication skills that specifically enhance the recognition and inclusion of underrepresented subpopulations in health research, contributing to diversity in science. Mentorship and supervision with Sponsor, Co-Sponsors, expert consultants and collaborator will occur on a regular basis throughout the fellowship award to augment all aspects of training.

项目概要/摘要 南亚人是美国人口增长最快的族裔群体。尽管他们的增加 就人口存在而言，南亚人仍然没有得到充分研究，并且经常与其他种族错误地聚集在一起 亚组。动脉粥样硬化性心血管疾病（ASCVD）在南亚裔美国人中非常普遍， 然而，关于这一人群中导致纵向过程的特定风险因素的数据仍然有限 ASCVD 的预防、早期干预和治疗方面可以进行修改。饮食是一个 通过饮食控制高血压 (DASH) 建立 ASCVD 风险预防模式 饮食模式是国家心肺血液研究所 (NHLBI) 推荐的治疗饮食。 NHLBI 在其研究重点中确定了八个目标，包括对因素的调查 解释人群健康差异（目标 3）和治疗策略的优化 预防、治疗和治愈疾病（目标 5）。拟议研究的主要目标是解决这些问题 通过分析必要的数据来了解与 DASH 饮食模式的一致性，从而实现目标 影响南亚裔美国人的 ASCVD 风险。这一目标将通过利用来自 居住在美国的南亚人动脉粥样硬化的介质 (R01HL093009)，一个正在进行的纵向队列 对居住在美国的南亚成年人进行的研究：探讨 DASH 饮食一致性与 确定 ASCVD 行为危险因素（吸烟、缺乏运动、饮酒）（目标 1）； 确定 DASH 饮食一致性与中心性肥胖指标之间的关联，基于 计算机断层扫描成像和人体测量（目标 2）；并确定关联 DASH 饮食一致性与 ASCVD 临床危险因素（血压和新型冠状动脉疾病）之间的关系 动脉钙评分）（目标 3）。拟议的研究将在纽约大学（NYU）进行，该大学 提供对纽约大学图书馆的访问，该图书馆拥有丰富的计算机化目录，可以对大多数开放式图书馆提供数字访问 堆栈产品；数据服务，为专业软件包提供访问、培训和支持 统计分析；以及支持提案制定和促进研究的强大研究基础设施 纽约大学教师和学生的参与度。奖学金授予期间的培训目标包括 (1) 开发和完善数据协调、管理和二次数据分析方面的技能； (2) 实施根据食物频率调查问卷改编的文化相关的 DASH 饮食模式评分， 每月接受共同主办方的培训； (3)了解ASCVD的近端和远端危险因素 在南亚人中； (4) 提高研究沟通技巧，特别提高认可度 将代表性不足的亚人群纳入健康研究，促进科学的多样性。 赞助商、联合赞助商、专家顾问和合作者的指导和监督将在 定期发放研究金，以加强各方面的培训。