Clinical validation of cardiac strain measures with real-time 4D ultrasound

使用实时 4D 超声测量心脏应变的临床验证

• 批准号: 7914454
• 负责人: Andrew Francis Laine
• 金额: $ 51.23万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7914454
• 关键词: Algorithms; Arts; Biomechanics; Biomedical Engineering; Canis familiaris; Cardiac; Cardiac Catheterization Procedures; Clinical; Clinical Research; Collaborations; Complex; Confined Spaces; Congenital Heart Defects; Data; Data Set; Development; Echocardiography; Endocardium; Epicardium; Evaluation Studies; Exercise stress test; Four-Dimensional Echocardiography; Four-dimensional; Goals; Gold; Heart; Image; Imagination; Imaging Techniques; Imaging technology; Implant; Ischemia; Laboratories; Magnetic Resonance Imaging; Manuals; Measurement; Measures; Medicine; Methods; Metric; Monitor; Motion; Myocardial; Myocardium; Optics; Patients; Performance; Phase; Procedures; Process; Quantitative Evaluations; Research; Risk; Screening procedure; Staging; Techniques; Technology; Testing; Time; Tissues; Torsion; Two-Dimensional Echocardiography; Ultrasonography; Universities; Validation; Work; base; bioimaging; cardiography; clinical Diagnosis; clinical application; design; diabetic cardiomyopathy; evaluation/testing; healthy volunteer; heart imaging; heart motion; improved; in vivo; new technology; novel; patient population; public health relevance; research clinical testing; tool; validation studies

DESCRIPTION (provided by applicant): Technology for imaging the heart has advanced dramatically in recent years. In particular, real-time three-dimensional ultrasound (RT3D or 4D) has captured the imagination of cardiologists with its ability to obtain complete three-dimensional images of the heart over an entire cardiac cycle in just a few seconds of imaging. The complex cardiac wall motion and temporal information contained in these four-dimensional (3D + time) data sequences has the potential to greatly enhance clinical diagnoses of the heart. However, most cardiac examination centers still depend on 2D echocardiography, and the temporal information in the 4D cardiac imaging is often overlooked. The goal of this proposal is to utilize the wealth of information contained in 4D ultrasound. In particular, this proposal will focus on a common problem for which 4D cardiac imaging is ideally suited: measuring strain and cardiac torsion directly from 4D ultrasound. The aims of this proposal are: (1) Quantify errors of displacement and strain from optical flow on 4D ultrasound with respect to results obtained by sonomicrometry implanted in dog hearts; (2) Test the hypothesis that optical flow on 4D ultrasound can have clinically equivalent results on healthy volunteers (normal hearts) and diseased hearts compared to similar measures of strain obtained by MRI based methods; (3) Test the hypothesis that optical flow on 4D ultrasound has specific advantages in terms of performance over existing 2D based methods of strain estimation. The design of our method is based on optical flow to track myocardial motion in 4D ultrasound. Directional displacements and strains and cardiac torsion can be automatically derived from the 3D + time motion field estimated. In aims 1 and 2, specific displacements, strains, and torsion will be measured and compared to "gold standards" in quantitative evaluation studies. In aim 3, we will extensively compare the performance of 4D methods and 2D methods in estimating strain measures across a wide range of clinical echocardiography patient data sets. Once completed, the questions of why and when to best use 4D rather then 2D measures will be answered quantitatively. PUBLIC HEALTH RELEVANCE: The significance of the proposed work is that it will provide a novel and effective 3D strain and torsion measuring tool, allowing clinicians to routinely measure wall motion quantitatively and in real-time. In addition this research will provide cardiologists with improved screening tests for diabetic cardiomyopathy (and dyssynchrony) to help them determine those patients that may require more invasive and costly procedures such as heart catheterization from patients that can be safely spared such tests.

描述（由申请人提供）：近年来，用于成像心脏的技术已经显着提高。特别是，实时的三维超声（RT3D或4D）捕捉了心脏病专家的想象力，其能力在短短几秒钟内就可以在整个心脏周期中获得整个心脏周期的完整三维图像。这些四维（3D +时间）数据序列中包含的复杂心脏壁运动和时间信息有可能大大增强心脏的临床诊断。但是，大多数心脏检查中心仍然取决于2D超声心动图，并且通常会忽略4D心脏成像中的时间信息。该提案的目的是利用4D超声中包含的大量信息。特别是，该提案将集中于4D心脏成像是理想情况下的常见问题：直接从4D超声波上测量应变和心脏扭转。该提案的目的是：（1）量化4D超声上的位移和应变的误差，相对于植入狗心脏植入的Sonomictry的结果； （2）与基于MRI基于MRI的方法获得的类似菌株相比，4D超声上的光流在4D超声上的光流可以在健康志愿者（正常心脏）和患病的心脏上具有等效的结果； （3）检验以下假设：4D超声上的光流在性能上比现有2D菌株估计方法具有特定的优势。我们方法的设计基于光流，以跟踪4D超声中的心肌运动。方向位移，菌株和心脏扭转可以自动从估计的3D +时间运动场得出。在目标1和2中，将测量特定的位移，菌株和扭转，并将其与定量评估研究中的“金标准”进行比较。在AIM 3中，我们将广泛比较4D方法和2D方法的性能，以估算广泛的临床超声心动图患者数据集的应变度量。完成后，将对为什么以及何时最佳使用4D而不是2D措施的问题进行定量回答。 公共卫生相关性：拟议工作的重要性是，它将提供一种新颖有效的3D菌株和扭转测量工具，使临床医生可以实时和实时测量壁运动。此外，这项研究还将为心脏病学家提供改进的糖尿病心肌病（和异议障碍）的筛查测试，以帮助他们确定那些可能需要更具侵入性和昂贵程序的患者，例如可以安全地保留此类测试的患者的心脏导管。