Development of bioactive probes and anti-cancer agents

生物活性探针和抗癌剂的开发

• 批准号: 7734328
• 负责人: William Trenkle
• 金额: $ 25.34万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7734328
• 关键词: American Cancer Society; Antineoplastic Agents; Apoptosis; Biological; Biological Assay; Biological Process; Breast; Cell Death; Cells; Cessation of life; Chemical Structure; Class; Colorectal; Complex; Core Facility; Development; Drug Kinetics; Genetic; Glycogen Storage Disease Type VII; Glycogen storage disease type II; Goals; Lead; Lung; Malignant Neoplasms; Metabolic; Metabolic Diseases; Pathogenesis; Peptide Nucleic Acids; Preparation; Process; Property; Prostate; Proteins; Resistance; Role; Skeletal Muscle; Structure; Structure-Activity Relationship; United States; base; cancer cell; cancer therapy; cancer type; cytotoxicity; desire; improved; inhibitor/antagonist; neoplastic cell; novel; research study; therapy development

This project has discovered and developed a novel chemotype for the potential treatment of cancer. The studies underway have elucidated some of the key chemical structure necessary for the observed activity and further studies are underway to fully delineate the structure activity relationships of this class of molecules. The development of these molecules is underway to advance from the initial hit into a lead structure for treatment development. Additionally the core has facilitated the preparation of other biological probes for the study biologically relevant processes. Projects collaboratively supported by the core facility include: Z01 DK036136-02 -- The deubiquitinating inhibitor EerI induces tumor cell apoptosis Z01 AR041099-17 -- Genetic Metabolic Myopathies--phosphofructokinase/acid Maltase Deficiency Z01 AR041165-01 -- Role of Skeletal Muscle SIRT1 in the Pathogenesis of Metabolic Disorders Z01 DK031119-04 -- Chemically Modified Peptide Nucleic Acids

该项目发现并开发了一种用于癌症潜在治疗的新型化学型。 正在进行的研究阐明了观察到的活性所需的一些关键化学结构，并正在进行进一步的研究，以充分描述这类分子的结构活性关系。 这些分子的发展正在进行中，从最初的打击到铅结构以进行治疗开发。 此外，核心促进了为研究生物学相关过程的其他生物探针的制备。 核心设施协作支持的项目包括： Z01 DK036136-02-去泛素化抑制剂EERI诱导肿瘤细胞凋亡 Z01 AR041099-17-遗传代谢肌病 - 磷酸果糖酶/酸麦芽糖酶缺乏症 Z01 AR041165-01-骨骼肌SIRT1在代谢疾病发病机理中的作用 Z01 DK031119-04-化学修饰的肽核酸