DNA Microarray Shared Resource

DNA 微阵列共享资源

• 批准号: 7623567
• 负责人: Gavin J Sherlock
• 金额: $ 8.13万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7623567
• 关键词: Antibodies; Archives; Bioinformatics; Biological Assay; Cancer Center; Cataloging; Catalogs; Cells; Custom; DNA Microarray Chip; DNA Microarray format; Data; Data Analyses; Databases; Ensure; Experimental Designs; Future; Genomics; Goals; Imagery; Informatics; Label; Malignant Neoplasms; Microarray Analysis; Microarray Shared Resource; Phase; Production; Protein Array; Protocols documentation; Publications; Publishing; Reagent; Research; Resource Sharing; Resources; Sampling; Services; Signal Transduction; Solutions; Spottings; Techniques; Training; anticancer research; base; design; functional genomics; member; new technology; novel strategies; programs; research study; success; tool

The goal of the DNA Microarray Shared Resource (DMSR) is to facilitate the application of cutting-edge microarray technology and analysis techniques by Cancer Center members. Services provided include the production of catalog and custom spotted microarrays, support of the use of multiple formats of Stanford and commercial microarrays, assistance with experimental design, archiving of array data and bioinformatics tools for the annotation, analysis, visualization and publication of microarray data. DMSR combines the resources of the Stanford Functional Genomics Facility, which develops new technology for genomics, and the Stanford Microarray Database, which is the largest and mostly widely used public database supporting microarray research. DMSR provides added value to Cancer Center members by decreasing the financial barriers associated with microarray experiments and providing the necessary training and expertise needed for the design, execution, analysis and publication of microarray experiments. Our strongly integrated genomics and informatics groups routinely interact with Cancer Center members to ensure that the microarray data generated are high quality and securely archived for analysis and interpretation as well as publication and long-term access. The current success of this Shared Resource is demonstrated by the high-impact publications that have been supported. As of July 2005, 59 cancer studies supported by the Shared Resource have been published, 14 of which were published in 2005. In fiscal year 2005, use of the microarray and data services totaled 15,937, of which 51% are by Cancer Center members from nine out of ten Research Programs. Future plans for this Shared Resource include expansion of the genomics efforts into all forms of microarray-based assays including antibody arrays, protein arrays, and reverse-phase cell lysate arrays. In addition, our bioinformatics capabilities will be significantly expanded by the incorporation of novel approaches for quality assessment, data analysis and annotation of data with cancer-related information.

DNA微阵列共享资源（DMSR）的目标是促进尖端的应用 癌症中心成员的微阵列技术和分析技术。提供的服务包括 目录和定制斑点微阵列的生产，支持多种格式的使用 斯坦福大学和商业微阵列，实验设计的协助，阵列数据的存档和 微阵列数据的注释，分析，可视化和发布的生物信息学工具。 DMSR结合了Stanford功能基因组学设施的资源，该设施开发了新的 基因组学技术和斯坦福微阵列数据库，该数据库是最大的，大多数是广泛的 使用了支持微阵列研究的公共数据库。 DMSR为癌症中心提供了附加值 成员通过减少与微阵列实验相关的财务障碍并提供 设计，执行，分析和出版所需的必要培训和专业知识 微阵列实验。我们强烈整合的基因组学和信息学组通常会互动 与癌症中心成员一起确保生成的微阵列数据是高质量且安全的 存档以进行分析和解释以及出版和长期访问。当前的成功 支持的高影响力出版物证明了这一共享资源。作为 2005年7月，共享资源支持的59项癌症研究已发表，其中14项是 于2005年出版。在2005财政年度，使用微阵列和数据服务总计15,937 51％的是十分之九的研究计划中的癌症中心成员。未来的计划 共享资源包括将基因组学工作扩展到所有形式的基于微阵列的测定中 包括抗体阵列，蛋白质阵列和反相裂解液阵列。另外，我们的 通过合并新方法的生物信息学能力将大大扩展 质量评估，数据分析和与癌症相关信息的数据注释。