Core Center--NIDCD Research Core Center P30

核心中心--NIDCD研究核心中心P30

• 批准号: 7486234
• 负责人: Edwin W Rubel
• 金额: $ 73万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-25 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7486234
• 关键词: Core; Center; NIDCD; Research; P30

DESCRIPTION (provided by applicant): This document requests renewal of the UW Research Core Center Grant that provides important infrastructure support for a large research commitment to the mission area of NIDCD. The NIDCD-funded Research Base is composed of 18 grants to 17 investigators with an annual direct cost of over $4.2 million. In addition, 10 grants and two K-awards to 8 investigators are included because they are in the mission area of NIDCD. Four Research Cores provide support for the research programs, and stimulate interactions and collaborations among investigators. Core A, the Human Subjects Recruitment Core, continues the longstanding function of recruiting and scheduling human infant subjects that meet specific criteria for studies on development of hearing and language perception. This Research Core has added services that facilitate recruitment of subjects with specific hearing and perceptual impairments. Core B, the Computer Resources Core, provides personnel with skills needed for software development for real-time physiological and behavioral investigations of auditory processing in animals and humans. Also, a systems and network manager teaches and advises investigators on optimal computer solutions. Core C, the Imaging Core, provides personnel and equipment maintenance for programs making extensive use of modern digital microscopic imaging methods including confocal microscopy, 3-dimensional reconstructions, and quantitative analyses of cellular attributes. This Core also supports human brain imaging initiatives. Core D, the Genetics Core, controls breeding and DMA screening for investigators using inbred and genetically manipulated mouse strains. Equipment is provided for rapid analyses of DMA sequences and for embryo preservation to enhance the efficiency of studies using mouse models of communication disorders. The Research Cores are supported by an Administrative Core that oversees the operations of each Research Core, organizes group meetings, provides clerical, fiscal, and personnel support, and prepares reports to the funding agency.

描述（由申请人提供）：本文档要求续签UW Research Core Center Grant，该拨款为NIDCD任务领域的大型研究承诺提供重要的基础设施支持。 NIDCD资助的研究基础由17名调查人员的18赠款组成，每年直接成本超过420万美元。此外，包括10个调查人员的10个赠款和2个K澳元，因为它们位于NIDCD的任务领域。四个研究核心为研究计划提供了支持，并刺激了研究人员之间的互动和协作。核心A，人类受试者招募核心，延续了招募和安排人类婴儿的长期功能，这些受试者符合特定的听力和语言知觉研究的特定标准。该研究核心增加了服务，以促进具有特定听力和知觉障碍的受试者招募。 Core B是计算机资源核心，为人员提供了针对动物和人类听觉处理实时生理和行为调查的软件开发技能。此外，系统和网络经理还向调查人员提供有关最佳计算机解决方案的建议。核心C（成像核心）为程序提供了人员和设备维护，用于广泛使用现代数字显微镜成像方法，包括共焦显微镜，三维重建以及对细胞属性的定量分析。该核心还支持人脑成像计划。核D（遗传学核心）使用近交和遗传操纵的小鼠菌株来控制研究人员的育种和DMA筛查。提供了用于快速分析DMA序列和胚胎保存的设备，以使用沟通障碍的小鼠模型来提高研究的效率。研究核心得到了一个管理核心的支持，该核心负责监督每个研究核心的运作，组织小组会议，提供文书，财政和人员支持，并为资助机构准备报告。