CTN: Northern New England Node

CTN：新英格兰北部节点

• 批准号: 7779738
• 负责人: Roger D. Weiss
• 金额: $ 12.62万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7779738
• 关键词: Adherence; Adopted; Arts; Attention deficit hyperactivity disorder; Caring; Clinical; Clinical Trials Network; Communities; Dependence; Development; Drug abuse; Evidence based practice; Funding; HIV; Health Personnel; Intervention; Lead; Leadership; Life; Mission; National Institute of Drug Abuse; New England; Opioid Analgesics; Participant; Patients; Performance; Pharmaceutical Preparations; Play; Progress Reports; Randomized; Randomized Controlled Clinical Trials; Reporting; Research; Research Personnel; Role; Science; Site; Substance Use Disorder; Testing; Universities; Viral Load result; addiction; community based treatment; design; expectation; improved; meetings; member; methadone maintenance; programs; response; treatment as usual; treatment program; working group

DESCRIPTION (provided by applicant): This is a proposal for renewal of "Clinical Trials Network (CTN): Harvard University Northern New England Node," submitted in response to RFA-DA-07-001 "Announcement of a Limited Competition of the National Drug Abuse Treatment Clinical Trials Network (U10)." The Northern New England Node (NNEN) brings together research expertise, sophisticated community treatment programs (CTPs), and a wide variety of patients being treated in diverse settings and multiple levels of care. The Node is characterized by a partnership between academic researchers and community-based treatment providers throughout 5 New England states to design and implement addiction treatment studies in community-based treatment programs. The NNEN has demonstrated outstanding progress since entering the CTN in 2002, with a combination of scientific and administrative leadership and excellent trial performance. The NNEN is the Lead Node on a multi-site study of prescription opioid analgesic dependence treatment, and has played a major scientific leadership role in the development and implementation of two CTN studies of patients with substance use disorder and attention deficit hyperactivity disorder. Administrative leadership is exemplified by participation by NNEN members on the 4 key CTN national committees; the NNEN is the only Node to be represented on all of these committees. NNEN members have also been elected to chair several national committees and work groups, demonstrating their excellent reputation among their CTN colleagues. Trial performance has been exemplary: the NNEN has participated in more trials and randomized more participants than any other Node entering in 2002; and has randomized more than twice as many participants in the 2005-2006 Node Trial Performance Report than the average for a CTN Node. Moreover, according to the most recent NIDA Trial Progress Report, the NNEN is the only Node (other than the 2 new Nodes entering the CTN in 2005) to meet or exceed expectations on every performance indicator of every trial the Node has entered. NNEN CTPs have adopted a number of new evidence-based practices, and have themselves disseminated information about these practices regionally, nationally, and internationally. This proposal highlights the accomplishments of the Northern New England Node in the funding period since September 2002. While the Node has made outstanding progress, the proposal also details a number of enhancements to strengthen the NNEN during the renewal period. During the next three years, the NNEN plans to continue to advance the mission of the CTN by implementing and testing state-of-the-art drug abuse treatment interventions, so that clinical programs will use the best treatments available and patients will receive the full benefit of the evolving science of addiction treatment.

描述（由申请人提供）：这是“临床试验网络（CTN）：哈佛大学北部新英格兰节点”的续签提案，响应RFA-DA-07-001的响应。北部新英格兰节点（NNE）汇集了研究专业知识，复杂的社区治疗计划（CTP），以及在各种环境和多个护理中接受治疗的各种患者。该节点的特征是学术研究人员与基于社区的治疗提供者之间的合作伙伴关系，以在基于社区的治疗计划中设计和实施成瘾治疗研究。自2002年进入CTN以来，NNEN取得了出色的进步，其科学和行政领导和出色的审判表现结合在一起。 NNEN是对处方阿片类镇痛依赖性治疗的多站点研究的主要节点，并且在开发和实施两项CTN研究中，对患有药物使用障碍和注意力缺乏障碍的患者的CTN研究发挥了重要的科学领导作用。 NNEN成员参与了4个关键CTN国家委员会的参与来体现行政领导； NNEN是所有这些委员会中唯一代表的节点。 NNEN成员还选择主席多个国家委员会和工作组，并在CTN同事中享有良好的声誉。试验性能是典范的：NNEN参加了更多的试验，并且比2002年其他任何其他节点都随机分配了更多的参与者；并且在2005 - 2006年的节点试验性能报告中，随机分组的参与者是CTN节点的平均值。此外，根据最新的NIDA试验进度报告，NNEN是唯一一个节点（除了2005年进入CTN的2个新节点以外）可以满足或超过节点输入每个试验的每个性能指标的预期。 NNEN CTP采用了许多新的基于证据的实践，并在区域，国内和国际上已经传播了有关这些做法的信息。该提议强调了自2002年9月以来的资助期内北部新英格兰节点的成就。尽管该节点取得了不错的进步，但该提案还详细介绍了许多增强功能，以增强NNEN的续期。在接下来的三年中，NNEN计划通过实施和测试最先进的药物滥用治疗干预措施来继续推进CTN的任务，以便临床计划将使用可用的最佳治疗方法，并且患者将获得成瘾治疗的不断发展的科学。