Complementary/Alternative Medicine: Expectancy & Outcom*

补充/替代医学：预期

• 批准号: 7937677
• 负责人: Barry S Oken
• 金额: $ 16.3万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7937677
• 关键词: Affect; Animal Model; Area; Biological; Clinical; Clinical Research; Clinical Trials Design; Collaborations; Communication; Complementary and alternative medicine; Development; Disease; Expectancy; Functional disorder; Funding; Future; Genetic Polymorphism; Genetic Transcription; Health Sciences; Human; Institution; Knowledge; Lead; Medicine; Mind-Body Intervention; Modeling; Naturopathy; Neuropharmacology; Neurosciences; Neurotransmitters; Oregon; Oriental Medicine; Persons; Placebo Effect; Placebos; Psychology; Research; Research Infrastructure; Research Personnel; Techniques; Universities; base; chiropracty; college; hypothalamic-pituitary-adrenal axis; improved; insight; model development; neuroimaging

There are factors related to a person and a clinical interaction that produce biological effects without directly affecting the underlying pathophysiology of a disease. The term placebo effects, although not ideal, is used to describe these non-specific effects. Placebo effects was specifically listed as a potential theme in the RFA to which this proposal is responding. Despite varying opinions about the size of placebo effects because of significant methodologic problems, the biologic basis of placebo effects is starting to be understood. It is very important to continue to define and understand these non-specific effects in order to: develop strategies that maximize these beneficial effects; improve clinical trial design; and gain insight into mechanisms of mind- body medicine. This proposal contains 4 projects that will develop models of placebo effects with objective markers and will explore predictors of placebo resonses. The proposal will take advantage of current knowledge in neuroscience and psychology to explore this area, including markers for hypothalamic-pituitary-adrenal axis activity and genetic polymorphisms affecting neurotransmitter function. These assessments as well as good communication between all coleaders will provide synergy across the projects. The interchange with non-human researchers is important to clinical research and this center proposal includes 1 animal model of placebo effect. This developmental center will lead to future projects that will follow on the planned research potentially using other techniques such as RNA expression, neuroimaging, and further neuropharmacology, but believe that the model development and initial exploration of predictors of placebo responses are the critical pieces that can be reliably achieved over the 3 year developmental funding period. This proposal constitutes a unique collaborative effort by Oregon Health & Science University, the National College of Naturopathic Medicine, the Oregon College of Oriental Medicine and Western States Chiropractic College. These institutions have already had ongoing collaborative arrangements. The Developmental Centers for Research on CAM U19 mechanism will strengthen these collaborations and further establish research infrastructure at the CAM institutions with a very promising exploration intoan area of mind-body medicine that is of critical importance to CAM and all conventional medicine.

有一些因素与一个人和临床相互作用有关的因素会产生生物学作用，而不会直接影响疾病的潜在病理生理学。术语安慰剂效应虽然不是理想的，但用于描述这些非特异性效应。安慰剂效果被特别列为RFA的潜在主题，该提案正在做出响应。尽管由于重大的方法论问题而对安慰剂效应的大小有不同的看法，但安慰剂效应的生物学基础开始被理解。继续定义和理解这些非特异性效应以制定以下策略，从而最大程度地发挥这些有益效果非常重要；改善临床试验设计；并深入了解思维身体医学机制。该建议包含4个将开发安慰剂模型的项目 带有客观标记的影响，并将探索安慰剂纪念子的预测因子。该提案将利用当前在神经科学和心理学方面的知识来探索该领域，包括下丘脑 - 垂体 - 肾上腺轴活动的标记和影响神经递质功能的遗传多态性。 这些评估以及所有coleaders之间的良好沟通将在整个项目中提供协同作用。与非人类研究人员的互换对临床研究很重要，该中心提议包括1种安慰剂效应的动物模型。这个发展中心将导致未来的项目，这些项目将使用其他技术（例如RNA表达，神经影像学和进一步的神经药理）进行，但相信安慰剂反应的预测指标是在3年年度发展融资期内可靠地实现的关键部分。该建议构成了俄勒冈健康与科学大学，国家自然疗法医学院，俄勒冈州东方医学学院和西方国家脊骨疗法学院的独特合作努力。这些机构已经进行了持续的协作安排。 CAM U19机制的研究中心将 加强这些合作，并在CAM机构中进一步建立研究基础设施，以非常有前途的探索对人的思维医学领域，这对于CAM和所有常规医学至关重要。

项目成果

Sensitivity to mental effort and test-retest reliability of heart rate variability measures in healthy seniors.

• DOI: 10.1016/j.clinph.2011.02.032
• 发表时间: 2011-10
• 期刊: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
• 作者: Mukherjee S;Yadav R;Yung I;Zajdel DP;Oken BS
• 通讯作者: Oken BS

Feasibility and performance evaluation of generating and recording visual evoked potentials using ambulatory Bluetooth based system.

使用基于移动蓝牙的系统生成和记录视觉诱发电位的可行性和性能评估。

• DOI: 10.1109/iembs.2010.5625955
• 发表时间: 2010
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Ellingson,RogerM;Oken,Barry
• 通讯作者: Oken,Barry

Effect of expectancy and personality on cortical excitability in Parkinson's disease.

• DOI: 10.1002/mds.25471
• 发表时间: 2013-08
• 期刊: MOVEMENT DISORDERS
• 影响因子: 8.6
• 作者: Lou, Jau-Shin;Dimitrova, Diana M.;Hammerschlag, Richard;Nutt, John;Hunt, Elizabeth A.;Eaton, Ryan W.;Johnson, Sarah C.;Davis, Melanie D.;Arnold, Grace C.;Andrea, Sarah B.;Oken, Barry S.
• 通讯作者: Oken, Barry S.