Demonstration Project: State-Based Screening for Chronic Kidney Disease

示范项目：国家慢性肾脏病筛查

• 批准号: 7936501
• 负责人: ALLAN J. COLLINS
• 金额: $ 40万
• 依托单位: NATIONAL KIDNEY FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7936501
• 关键词: Demonstration; Project; State; Based; Screening

DESCRIPTION (provided by applicant): The Centers for Disease Control and Prevention (CDC) has released Request for Applications (RFA) Number RFA DP-06-004: Demonstration Project for Identifying Individuals at High-Risk for Chronic Kidney Disease. This application is from Allan J. Collins, MD (Organization: National Kidney Foundation; Other Significant Contributors: Chronic Disease Research Group). The Specific Aims are to: (1) use National Health and Nutrition Examination Survey (NHANES) and United States Renal Data System (USRDS) data to identify and Kidney Early Evaluation Program (KEEP) data to validate simple measures to select individuals at high risk for chronic kidney disease (CKD); (2) use NHANES data to identify and KEEP data to validate a panel of clinical measures to determine the kidney health status of people at risk for CKD; (3) use the KEEP database to longitudinally assess the kidney health status of individuals at high risk for CKD; (4) in collaboration with the CDC, implement a CKD screening process in four states; (5) assess the ability of the screening process to accurately identify and stage individuals at high risk for CKD; (6) demonstrate the ability of the screening process to improve the identification, staging, and treatment of individuals at high risk for CKD; and (7) produce a report to guide implementation of the demonstration project in other states. The achievement of these aims will fulfill the RFA's intent to develop a screening system for use in four states that will demonstrate the ability of such a system to improve the identification, staging, and treatment of individuals with CKD. Because education plays an important part in disease control and prevention, promotion of CKD awareness to patients, physicians, and communities will be part of this effort. The CKD screening system envisioned in this application also seeks to improve treatment of a devastating complication of CKD, cardiovascular disease. RELEVANCE TO PUBLIC HEALTH: Approximately 20 million adults in the United States have significant kidney disease and/or kidney damage, with millions more at risk due to conditions such as diabetes and hypertension. The screening system proposed in this application addresses the public-health need to target high-risk individuals in order to improve prevention and control of CKD and reduce the cost of its treatment.

描述（由申请人提供）：疾病控制与预防中心（CDC）发布了应用要求（RFA）编号RFA DP-06-004：示范项目，用于识别高风险的慢性肾脏疾病的人。 该应用来自医学博士Allan J. Collins（组织：国家肾脏基金会；其他重要贡献者：慢性病研究小组）。 具体目的是：（1）使用国家健康和营养检查调查（NHANES）和美国肾脏数据系统（USRDS）数据来识别和肾脏早期评估计划（Keep）数据，以验证简单的措施，以选择具有慢性肾脏疾病高风险的人（CKD）； （2）使用NHANES数据识别和保留数据以验证一系列临床措施，以确定有CKD风险的人的肾脏健康状况； （3）使用Keep数据库纵向评估CKD高风险的个体的肾脏健康状况； （4）与CDC合作，在四个州实施CKD筛选过程； （5）评估筛选过程准确识别和分期为CKD风险高风险的人的能力； （6）证明了筛选过程改善CKD高风险的个体的识别，分期和治疗的能力； （7）提出一份报告，以指导其他州的示范项目的实施。 这些目标的实现将满足RFA在四个州开发筛选系统的意图，这将证明这种系统可以改善CKD个体的识别，分期和治疗的能力。 由于教育在疾病控制和预防方面起着重要的作用，因此对患者，医师和社区提高CKD意识将成为这一努力的一部分。 本应用程序中设想的CKD筛查系统还旨在改善CKD，心血管疾病的毁灭性并发症的治疗。 与公共卫生有关：美国约有2000万成年人患有严重的肾脏疾病和/或肾脏损害，由于糖尿病和高血压等疾病，数百万的风险更高。本申请中提出的筛查系统解决了针对高风险个人的公共卫生，以改善对CKD的预防和控制并降低其治疗成本。