Next Generation Cone Beam CT with Improved Contrast Resolution and Added Spectral Imaging Functionality

下一代锥束 CT 具有改进的对比度分辨率并增加了光谱成像功能

• 批准号: 10660754
• 负责人: Guang-Hong Chen
• 金额: $ 60.82万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-13 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10660754
• 关键词: 3-Dimensional; Affect; Algorithms; Animals; Bite; Brain imaging; Cadaver; Calibration; Canis familiaris; Clinical; Compton radiation; Data; Dedications; Detection; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Disease; Dose; Evaluation; Family suidae; Feasibility Studies; Future; Head; Hemorrhage; Human; Image; Intervention; Iodine; Lesion; Magnetic Resonance Imaging; Maps; Measures; Medical; Monitor; Morphologic artifacts; Operative Surgical Procedures; Patients; Performance; Physicians; Play; Procedures; Radiation; Resolution; Roentgen Rays; Role; Rotation; Scheme; Signal Transduction; System; Technology; Three-Dimensional Imaging; Tube; Visualization; X-Ray Computed Tomography; X-Ray Medical Imaging; accurate diagnosis; clinical application; cone-beam computed tomography; contrast enhanced; cost; data acquisition; design; detector; digital; disease diagnosis; high risk; human subject; image guided; image guided intervention; image guided radiation therapy; imaging capabilities; imaging detector; imaging modality; imaging platform; imaging system; improved; in vivo; innovation; minimally invasive; next generation; novel; photon-counting detector; preservation; prototype; quantitative imaging; quantum; research clinical testing; soft tissue; spectrograph; success; treatment planning; white matter

ABSTRACT Cone beam Computed Tomography (CBCT) with a digital flat panel detector (FPD) is the primary imaging workhorse for image-guided interventions. By rotating the tube-detector assembly around the patient, 3D cone beam CT (CBCT) data can be acquired to supplement 2D x-ray imaging and improve disease diagnosis, treatment planning, and treatment execution in medical procedures. Despite its volumetric coverage and high spatial resolution, FPD-based CBCT does not provide the necessary soft-tissue contrast resolution for intraoperative hemorrhage monitoring, gray-white matter differentiation, or the detection of other low-contrast lesions in a variety of imaging tasks. In addition, quantitative imaging capabilities that are much desired by physicians are lacking in the current CBCT technology. The overarching objective of this project is to develop an integrated PCD-FPD CBCT imaging platform by adding an x-ray photon counting detector (PCD) to the current CBCT system, enabling users to freelyswitch between the new PCD-CBCT imaging mode and the existing FPD-based imaging without interference between the two components. This new imaging platform offers the same soft-tissue contrast resolution and z-coverage as those of MDCT, but without requiring additional room space to house both MDCT and CBCT in the same suite. Additionally, the proposed system offers quantitative spectral CT imaging functionality at reduced radiation and contrast dose for image-guided interventions. To develop the integrated PCD-FPD CBCT imaging system and to explore its added value to medical diagnosis, three specific aims are planned. Aim #1 is designed to construct and calibrate a prototype PCD-CBCT system; Aim #2 is dedicated to the development of the novel correction algorithms needed to achieve artifact-free PCD-CBCT images; Aim #3 is dedicated to clinical feasibility studies using in vivo canine subjects and human subjects. Upon the completion of these aims, a prototype for the next-generation CBCT imaging system will have been constructed, calibrated, and evaluated; the system will be capable of consistently producing nearly artifact-free PCD-CBCT images with spectral imaging functionality and MDCT-like low-contrast detectability; the benefits and potential clinical applications of the integrated PCD-FPD CBCT imaging system will have been demonstrated.

抽象的 带有数字平板探测器 (FPD) 的锥束计算机断层扫描 (CBCT) 是主要成像 图像引导干预的主力。通过围绕患者旋转管探测器组件，3D 锥体 可以获得束 CT (CBCT) 数据以补充 2D X 射线成像并改善疾病诊断， 医疗程序中的治疗计划和治疗执行。尽管其体积覆盖率和高 空间分辨率，基于 FPD 的 CBCT 不能提供必要的软组织对比分辨率 术中出血监测、灰白质分化或其他低对比度的检测 各种成像任务中的病变。此外，定量成像能力也是人们非常期望的。 目前的 CBCT 技术缺乏医生的帮助。该项目的总体目标是 通过添加X射线光子计数探测器开发集成PCD-FPD CBCT成像平台 (PCD) 到当前的 CBCT 系统，使用户能够在新的 PCD-CBCT 成像之间自由切换 模式和现有的基于 FPD 的成像，两个组件之间没有干扰。这个新的 成像平台提供与 MDCT 相同的软组织对比分辨率和 z 覆盖范围，但是 无需额外的房间空间即可在同一套房内容纳 MDCT 和 CBCT。此外， 所提出的系统在减少辐射和对比剂剂量的情况下提供定量光谱 CT 成像功能 用于图像引导干预。开发集成PCD-FPD CBCT成像系统并探讨其 为了增加医疗诊断的价值，规划了三个具体目标。目标 #1 旨在构建和校准 原型 PCD-CBCT 系统；目标 #2 致力于开发新颖的校正算法 需要获得无伪影的 PCD-CBCT 图像；目标 #3 致力于使用体内进行临床可行性研究 犬类受试者和人类受试者。完成这些目标后，下一代的原型 CBCT成像系统已构建、校准和评估；该系统将能够 始终如一地生成几乎无伪影的 PCD-CBCT 图像，具有光谱成像功能和类似 MDCT 的功能 低对比度可检测性；集成 PCD-FPD CBCT 的优势和潜在临床应用 成像系统将得到演示。