Minimally invasive quantitative tissue oxygen sensors to personalize cancer care

微创定量组织氧传感器实现个性化癌症护理

• 批准号: 10698650
• 负责人: Gregory Ekchian
• 金额: $ 39.99万
• 依托单位: STRATAGEN BIO, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-14 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10698650
• 关键词: Aftercare; Anatomy; Animal Model; Animals; Benign Prostatic Hypertrophy; Biochemical; Brachytherapy Seeds; Canis familiaris; Cervical; Clinical; Clinical Data; Clinical Trials; Data; Devices; Dimensions; Dose; Effectiveness; Environment; Evaluation; Formulation; Foundations; Gases; Grant; Head and Neck Cancer; Head and neck structure; Health; Human; Hypoxia; Image; Immunotherapy; Innovation Corps; Interview; Lead; Literature; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of brain; Malignant neoplasm of cervix uteri; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Malignant neoplasm of prostate; Measurement; Measures; Methods; Modeling; Monitor; Mus; Nature; Oncology; Outcome; Oxygen; PC3 cell line; Patient-Focused Outcomes; Patients; Performance; Phase; Physiological; Pilot Projects; Polymers; Prostate; Radiation Dose Unit; Radiation therapy; Resistance; Resolution; Rodent Model; Science; Silicones; Site; Small Business Innovation Research Grant; Testing; Tissues; Trauma; Validation; Visual; Work; arm; biomaterial compatibility; chemotherapy; design; good laboratory practice; implantation; improved outcome; in vivo; malignant breast neoplasm; mechanical properties; migration; minimally invasive; mortality; personalized cancer care; personalized medicine; preclinical evaluation; programs; prostate cancer model; prostate enlargement; sensor; targeted treatment; technology validation; treatment planning; trend; tumor; tumor hypoxia

Project Summary and Abstract Hypoxic (oxygen depleted) tumors are more resistant to treatments including radiation therapy. This trend has been seen across a wide range of cancers including prostate, head and neck, and cervical. Radiobiological studies have shown that elevated radiation doses can be used to overcome hypoxia-induced resistance and achieve the same level of effectiveness as lower doses in more well-oxygenated environments. The major impediment to implementing this (and other) hypoxia targeting therapies is the lack of a suitable oxygen sensor. Actionable oxygen sensors should be quantitative, workflow compatible, and provide spatial context for each measurement. Current and past alternatives for oxygen sensing are either qualitative, too invasive, or both. The proposed oxygen sensor will offer a workflow-compatible method to obtain quantitative tumor oxygen data. The sensor is measured non-invasively using MRI which provides a spatial/anatomical context for each measurement. The sensor is made completely of silicone, inserted with minimally invasive methods, equilibrates quickly with the surrounding tissue, and is fully reversible. The polymeric nature of the material allows it to remain at the site of insertion indefinitely to enable long-term monitoring. The proposed work focuses on selection of a lead formulation (Aim 1), evaluation in a small animal tumor model (Aim 2), and evaluation in a large animal model to mimic the tissue volumes expected during human use (Aim 3). The sensor produced as part of this proposal will be translatable to additional applications in oncology, but also to non-oncology applications including tissue health and trauma.

项目概要和摘要 缺氧（缺氧）肿瘤对包括放射治疗在内的治疗更具抵抗力。这种趋势已经 已在多种癌症中发现，包括前列腺癌、头颈癌和宫颈癌。放射生物学 研究表明，提高辐射剂量可用于克服缺氧引起的抵抗力和 在氧气充足的环境中，可以达到与较低剂量相同的有效性水平。主要 实施这种（和其他）缺氧靶向疗法的障碍是缺乏合适的氧传感器。 可操作的氧气传感器应该是定量的、工作流程兼容的，并为每个传感器提供空间背景 测量。当前和过去的氧传感替代方案要么是定性的，要么是侵入性太大，或者两者兼而有之。这 所提出的氧传感器将提供一种与工作流程兼容的方法来获取定量肿瘤氧数据。这 使用 MRI 对传感器进行非侵入性测量，为每个传感器提供空间/解剖背景 测量。传感器完全由硅胶制成，采用微创方法插入，平衡 快速与周围组织融合，并且是完全可逆的。该材料的聚合性质使其能够保持 无限期地位于插入部位，以实现长期监测。拟议的工作重点是选择一个 先导制剂（目标 1）、小动物肿瘤模型评估（目标 2）以及大型动物评估 模型来模拟人类使用过程中预期的组织体积（目标 3）。作为其中一部分生产的传感器 该提案将可转化为肿瘤学的其他应用，也可转化为非肿瘤学的应用 包括组织健康和创伤。