Prevention and Treatment of Oral Biofilms and Related Oral Disease by Soluble Chi

溶气防治口腔生物膜及相关口腔疾病

• 批准号: 7670999
• 负责人: Shenda Baker
• 金额: $ 9.97万
• 依托单位: SYNEDGEN, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7670999
• 关键词: Acids; Address; Adhesions; Adhesives; Affect; Alginates; Anti-Bacterial Agents; Arginine; Atherosclerosis; Bacteria; Bacterial Adhesion; Biocompatible; Biopolymers; Blood Circulation; Breathing; Charge; Chitosan; Chronic; Data; Dental; Dental Plaque; Dental caries; Development; Devices; Disease; Divalent Cations; Dose; Drug Formulations; Effectiveness; Electrostatics; Endocarditis; Excision; Gingivitis; Goals; Growth; Heart Diseases; Incidence; Individual; Infection; Ingestion; Lead; Length; Lung; Mammals; Microbial Biofilms; Molecular Weight; Mouth Diseases; Nosocomial pneumonia; Oral; Oral cavity; Oral health; Oral mucous membrane structure; Periodontal Diseases; Periodontitis; Permeability; Phase; Polymers; Polysaccharides; Population; Prevention; Property; Pulpitis; Research; Resistance; Resistance development; Streptococcus mutans; Structure; Surface; Testing; Therapeutic; Tooth Diseases; Tooth structure; Viscosity; Work; antimicrobial; bactericide; base; biodegradable product; biomaterial compatibility; cohesion; commercial application; density; design; extracellular; in vivo; lactobionic acid; microbial colonization; novel; oral bacteria; oral biofilm; oral infection; oral pathogen; oral plaque; pathogenic bacteria; prevent; prophylactic; public health relevance; technological innovation; treatment effect

DESCRIPTION (provided by applicant): A need remains for safe and effective, prophylactic and therapeutic treatments for controlling bacterial populations in dental plaque and treating periodontal disease. We have developed derivatives of natural biopolymers that have demonstrable effectiveness in clumping a wide spectrum of bacteria and preventing the adhesion of biofilms. The technological innovation lies in enhancing the innate interactive properties of these molecules and developing means to create a very low dose, sustained preventative effect and treatment to reduce the occurrence of oral disease by disrupting bacterial adhesion and cohesion. The objective of this application is to explore the use of these newly synthesized soluble chitosan derivatives of various size and charge to prevent bacterial colonization via aggregation of free bacteria and to treat oral biofilms by reducing plaque cohesion and adhesion. Once the specific interactions between chitosan derivatives and oral pathogens, plaque, and plaque formation are understood, we can knowledgably develop product formulations that minimize the titer of oral pathogens, both free and in biofilms. This proposal specifically addresses the development of an oral rinse product to prevent and treat dental disease encompassing broad treatment applications including caries, periodontitis and pulpitis. Our novel agents interfere with microbial colonization and growth and are the basis of this proposal. This study will explore the use of newly synthesized soluble chitosan derivatives as agents to treat and prevent oral biofilms (dental plaque) with minimal affects on natural oral flora by aggregation of oral bacteria, erosion of plaque and prevention of adhesion of bacteria to plaque and oral surfaces. Longer term products will include treatments to reduce the bacterial populations in infected or diseased states via different dosing or treatment regimes. Given the biocompatibility, biodegradability and limited mechanism to resistance for this clumping mechanism, the applications these chitosan derivatives are expected to be far reaching. PUBLIC HEALTH RELEVANCE: This proposal examines the use of biopolymer derivatives that have demonstrable effectiveness in clumping a wide spectrum of bacteria and preventing the adhesion of biofilms for use in controlling oral biofilms. These products will provide low dose, highly effective, biocompatible, sustained preventative effect and treatment to reduce the occurrence of oral disease by disrupting bacterial adhesion and cohesion.

描述（由申请人提供）：需要安全有效，预防性和治疗性治疗，以控制牙菌斑和治疗牙周疾病中的细菌种群。我们已经开发了天然生物聚合物的衍生物，这些生物聚合物在汇总各种细菌并防止生物膜的粘附方面具有出色的有效性。技术创新在于增强这些分子的先天互动特性，并开发出产生非常低剂量的，持续的预防效果和治疗方法，以减少细菌粘附和凝聚力来减少口腔疾病的发生。本应用的目的是探索这些新合成的可溶性壳聚糖衍生物的使用，这些衍生物具有各种大小和电荷，以通过聚集游离细菌的聚集来防止细菌定植，并通过减少斑块的凝聚力和粘附来治疗口腔生物膜。一旦了解了壳聚糖衍生物与口腔病原体，斑块和斑块形成之间的特定相互作用，我们就可以知道可以最大程度地减少自由和生物膜中口服病原体的滴度的产物制剂。该建议专门针对口服冲洗产品的开发，以预防和治疗牙齿疾病，包括龋齿，牙周炎和牙髓炎，包括广泛的治疗应用。我们的新型药物干扰了微生物定植和生长，这是该提议的基础。这项研究将探讨新合成的可溶性壳聚糖衍生物作为治疗和预防口腔生物膜（牙pla）的用剂，从而通过口服细菌的侵蚀，斑块的侵蚀和对斑块和口腔围墙的细菌粘附的预防对天然口腔植物的影响最小。长期产品将包括通过不同的剂量或治疗方案减少感染或患病状态中细菌种群的治疗方法。鉴于这种结块机制的生物相容性，生物降解性和有限的耐药性机制，这些壳聚糖衍生物的应用预计将是遥不可及的。 公共卫生相关性：该提案研究了在结合各种细菌和防止生物膜粘附的生物聚合物衍生物的使用，可用于控制口腔生物膜。这些产品将提供低剂量，高效，生物相容性，持续的预防效果和治疗，以通过破坏细菌粘附和内聚力来减少口腔疾病的发生。