Stem Cell Niche Interactions

干细胞生态位相互作用

• 批准号: 7674459
• 负责人: ANDREW D ROBERTSON
• 金额: $ 0.6万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-21 至 2010-04-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7674459
• 关键词: Adult; Aging; Biological Models; Biology; British Columbia; Canada; Cell Proliferation; Cells; Collaborations; Daughter; Development; Developmental Biology; Embryo; Embryonic Development; Functional disorder; Learning; Malignant Neoplasms; Molecular; Pattern; Proliferating; Regenerative Medicine; Regulation; Scientist; Signal Transduction; Stem cells; Time; Tissues; Translating; Undifferentiated; adult stem cell; career; cell type; embryonic stem cell; interest; meetings; planetary Atmosphere; pluripotency; precursor cell; public health relevance; self-renewal; stem cell biology; stem cell niche; stemness; symposium

DESCRIPTION (provided by applicant): This proposal is to request support for a Keystone Symposia meeting entitled "Stem Cell Niche Interactions", organized by Markus Grompe, which will be held in Whistler, British Columbia, Canada from April 21 - 26, 2009. Embryonic stem cells are pluripotent precursors able to differentiate into the many cell types of the body. Adult or tissue stem cells are undifferentiated but lineage specific precursor cells able to proliferate long term while producing daughters that maintain the undifferentiated state (self-renew) and daughters that differentiate into specific cell types. In addition to their intrinsic interest for developmental biology, both kinds of stem cells have great promise for tissue renewal and regenerative medicine. Much has been learned in the past year about the mechanisms that maintain and induce stem cell pluripotency, the mechanisms that control differentiation, and the molecular regulation of stemness and self-renewal. Interactions between stem cells and their niches regulate self-renewal versus differentiation of adult stem cells and key signals from surrounding cells may organize fate decisions in space and time to pattern early embryonic development and differentiation of specific cell types. Understanding of the fundamental biology of embryonic and adult stem cells is being translated into development of "artificial niches" and conditions for controlling cell proliferation and differentiation. This meeting will bring together stem cell scientists from diverse model systems and backgrounds. All career levels will be represented. Current opportunities and challenges in the field will be highlighted in an atmosphere of informal exchange, facilitating new ideas and collaborations towards meeting the next great challenges in the field. PUBLIC HEALTH RELEVANCE: Embryonic stem cells are able to differentiate into the many cell types of the body. In addition to their intrinsic interest for developmental biology, stem cells have great promise for tissue renewal and regenerative medicine. This meeting will explore our current understanding of the biology of stem cells and their niches, the special microenvironments that dictate how stem cells operate, and whose dysfunction promotes cancer and aging.

描述（由申请人提供）：该提案是为了支持由Markus Grompe组织的Keystone研讨会会议，标题为“干细胞生态位相互作用”，该会议将于2009年4月21日至26日在加拿大不列颠哥伦比亚省惠斯勒举行，胚胎干细胞是多能分化为细胞类型的胚胎的前体。成人或组织干细胞是未分化的，但谱系特定的前体细胞能够长期增殖，同时产生女儿，这些女儿维持未分化的状态（自我更新），而女儿则分化为特定细胞类型。除了它们对发育生物学的内在兴趣外，两种干细胞对组织更新和再生医学都有很大的希望。在过去的一年中，关于维持和诱导干细胞多能力的机制，控制分化的机制以及干性和自我更新的分子调节的机制已经很多。干细胞及其壁ni之间的相互作用调节成人干细胞的自我更新与分化以及周围细胞的关键信号可能会在时空中组织命运决策，以模拟早期的胚胎发育和特定细胞类型的分化。了解胚胎和成年干细胞的基本生物学正在转化为“人造壁ches”的发展以及控制细胞增殖和分化的条件。这次会议将汇集来自不同模型系统和背景的干细胞科学家。所有职业水平将被代表。当前的机会和挑战将在非正式交流的氛围中强调，促进新的想法和合作，以应对该领域的下一个巨大挑战。 公共卫生相关性：胚胎干细胞能够区分人体的许多细胞类型。除了对发育生物学的内在兴趣外，干细胞还对组织更新和再生医学也有很大的希望。这次会议将探讨我们目前对干细胞及其壁ni的生物学的理解，即决定干细胞运作方式的特殊微环境以及其功能障碍促进癌症和衰老。