Mobile Elements in Mammalian Genomes

哺乳动物基因组中的移动元素

基本信息

批准号：
7748763
负责人：
SANDRA L MARTIN
金额：
$ 0.8万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-02 至 2010-06-30
项目状态：
已结题

项目摘要

DESCRIPTION: (provided by applicant): Partial support is requested for the third FASEB Summer Conference, "Mobile Elements in Mammalian Genomes" which will be held in Snowmass, CO, July 5-10, 2009. The objective of the meeting is to bring together a diverse group of investigators with a common interest in mobile DNA to discuss recent advances in how mobile elements have impacted and continue to influence the functional expression and evolution of mammalian genomes. The program comprises all aspects of mobile DNA including bioinformatics, biochemical, evolutionary, and population genetic studies on mammalian transposable elements, as well as work to exploit transposable elements for saturation mutagenesis and gene delivery. Comparative genomics provides strong evidence for mobile DNA amplification, repression and extinction in evolutionary time. Recently, detailed studies of the small inhibitory RNA pathway have provided strong evidence for derepression of mobile DNA in mutants of this pathway; the emerging interface of these two fields will be represented by a new session at this meeting. There will also be increased representation of studies that define a variety of roles for sequences derived from transposable elements in genome architecture and function. This timely conference will facilitate the sharing of exciting new findings, experimental challenges, and outstanding questions in this rapidly evolving field among students, post-doctoral trainees, and junior and senior principal investigators. PUBLIC HEALTH RELEVANCE: Mobile DNA has played, and continues to play a major role in shaping the structure and function of the mammalian genome. Retrotransposition deposits new copies of mobile DNA throughout the genome which can lead to gene disruption, modified expression of adjacent genes, and transduction of neighboring DNA; at the DNA level the resulting interspersed repeated sequences may give rise to novel regulatory networks, or provide a substrate for homologous recombination of mispaired sequences, leading to gene duplication, deletion, exon shuffling and chromosome translocation. Any one of the dynamic events caused by the presence and movement of mobile DNA in the human genome may lead to disease, including meiotic failure and infertility, inherited genetic diseases such as hemophilia and muscular dystrophy, and somatic diseases such as breast and colon cancer.

DESCRIPTION: (provided by applicant): Partial support is requested for the third FASEB Summer Conference, "Mobile Elements in Mammalian Genomes" which will be held in Snowmass, CO, July 5-10, 2009. The objective of the meeting is to bring together a diverse group of investigators with a common interest in mobile DNA to discuss recent advances in how mobile elements have impacted and continue to influence the functional expression and evolution of mammalian genomes.该计划包括移动DNA的各个方面，包括生物信息学，生化，进化和人群遗传研究，对哺乳动物可转座元素，以及利用可替代元素进行饱和诱变和基因递送的努力。比较基因组学为进化时间的移动DNA扩增，抑制和灭绝提供了有力的证据。最近，对小抑制性RNA途径的详细研究为该途径突变体中移动DNA的消除提供了有力的证据。这两个字段的新兴界面将由本次会议上的新会议代表。研究还将有更多的研究来定义从基因组结构和功能中可转移元素得出的序列的各种作用。这次及时的会议将促进在学生，博士后学员以及初级和高级首席调查人员之间在这个迅速发展的领域中分享令人兴奋的新发现，实验挑战和杰出问题。公共卫生相关性：移动DNA已经发挥了作用，并继续在塑造哺乳动物基因组的结构和功能中发挥重要作用。反转录沉积在整个基因组中沉积新的移动DNA副本，这可能导致基因破坏，相邻基因的改性表达以及相邻DNA的转导；在DNA水平上，所得的散布重复序列可能会产生新的调节网络，或者为错误序列的同源重组提供底物，从而导致基因重复，缺失，外显子洗牌和染色体易位。流动性DNA在人类基因组中的存在和运动引起的任何动态事件都可能导致疾病，包括减数分裂衰竭和不育，遗传性遗传疾病，例如血友病和肌肉营养不良，以及乳腺癌等体细胞疾病。