Core B - Sheep Core

核心B-羊核心

• 批准号: 7810209
• 负责人: VASANTHA PADMANABHAN
• 金额: $ 61.37万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7810209
• 关键词: Animals; Breeding; Caring; Disease; Exposure to; Fertility; Gestational Age; Gonadal Steroid Hormones; Human Resources; Individual; Maintenance; Metabolic; Postnatal Care; Pregnancy; Productivity; Program Research Project Grants; Qualifying; Reproductive Health; Research; Research Project Grants; Services; Sheep; Staging; Training; animal breeding; cost; experience; high standard; knowledge base; meetings; prenatal; programs; reproductive

The objective of the Sheep Core is to provide a mechanism whereby the services of common personnel are shared by all projects of this Program Project Grant, enabling cost-effective breeding and animal maintenance programs of exceptionally high standards. The underlying rationale for this Core is simple. A staff of well-qualified individuals can meet the needs of multiple research projects more effectively and economically than if each project were to meet its needs separately. This is especially important given that a major function of this core will be to generate sheep that have been programmed prenatally by exposure to gonadal steroids at known stages of pregnancy. This requires extensive experience and expertise of managing fertility, breeding, and early postnatal care in this experimental species. The Specific Aims of the Sheep Core are as follows. Specific Aim 1. To operate a breeding program to generate sheep those are prenatally treated with gonadal steroids at specific fetal ages and vehicle-treated controls for use by the three research projects that make up this Program Project Grant. Specific Aim 2. To coordinate effective and economical usage of sheep by three interrelated research projects. Specific Aim 3. To provide a uniform and high standard of animal maintenance and veterinary care. Specific Aim 4. To provide a technical knowledge base for reproductive research in sheep and train personnel in proper handling of animals. Specific Aim 5. To determine the metabolic status of the experimental animals required for meeting the needs of all 3 projects. By achieving these aims, the Sheep Core will greatly enhance the productivity of all projects in the Program Project Grant.

绵羊核心的目的是提供一种机制，普通人的服务是 该计划项目赠款的所有项目共享，实现了具有成本效益的育种和动物 具有异常高标准的维护计划。该核心的基本原理很简单。一个 合格个人的员工可以更有效地满足多个研究项目的需求，并且 在经济上，每个项目都分别满足其需求。考虑到一个 该核心的主要功能将是生成通过暴露于产前编程的绵羊 在已知妊娠阶段的性腺类固醇。这需要丰富的经验和专业知识 在该实验物种中管理生育能力，繁殖和早期产后护理。特定目标 绵羊核心如下。特定目标1。操作育种计划以生成绵羊 在特定胎儿年龄和媒介物处理的对照中用性腺类固醇治疗的产前治疗 构成该计划项目赠款的三个研究项目。特定目标2。协调有效 以及三个相互关联的研究项目对绵羊的经济用法。特定目标3。提供一个 统一和高标准的动物维护和兽医护理。特定目标4。提供一个 适当处理绵羊和培训人员生殖研究的技术知识库 动物。具体目标5。确定实验动物的代谢状态 满足所有3个项目的需求。通过实现这些目标，绵羊核心将大大增强 计划项目赠款中所有项目的生产力。