Clinical & Research Informatics

临床

• 批准号: 7734858
• 负责人: Chandan Sastry
• 金额: $ 646.84万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7734858
• 关键词: Accounting; Apache Indians; Area; Authorship; Bioinformatics; Biological; Budgets; Businesses; Childhood; Clinical; Clinical Research; Clinical Trials; Clinical Trials Database; Code; Collaborations; Collection; Computer software; Count; Custom; Data; Data Analyses; Data Coordinating Center; Databases; Development; Disease; Documentation; Education; Educational workshop; Endocrinology; Enrollment; Family; Family history of; Festival; Gene Expression Profile; Genes; Genome; Genomics; Germ Cells; Golgi Apparatus; Hospitals; Human Resources; Image; Imagery; Informatics; Intelligence; Internet; Intramural Research; Italy; Java; Label; Laboratories; Libraries; Licensing; Location; Logical Observation Identifiers Names and Codes; Maintenance; Manuscripts; Maps; Medical; Medical Illustration; Microscopy; Molecular; Museums; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Mental Health; Natural History; Numbers; Online Systems; Pamphlets; Patients; Pattern; Phase; Photography; Printing; Process; Production; Protocols documentation; PubMed; Publications; Reporting; Research; Research Personnel; Resource Informatics; Resources; Sampling; Secure; Services; Site; Software Engineering; Specific qualifier value; Structure; Students; Surveys; System; Systematized Nomenclature of Medicine; Techniques; Training; Translational Research; Unified Medical Language System; United States National Institutes of Health; Update; Work; animation; base; data integration; design; digital imaging; family structure; genetic pedigree; investigator training; male; organizational structure; programs; prototype; serial analysis of gene expression; software development; symposium; three-dimensional modeling; tool; translational medicine; wiki

This project is a core service for the Division of Intramural Research. It focuses on the development of informatics tools to support multiple investigators and a variety of disease areas. The informatics systems and services support NICHD researchers and investigators from other programs at NIDCR, NINR, NIDCR, NIAMS, NIMH, and NIDDK. CLINICAL INFORMATICS This research area focuses on the development of applications and services in the areas of clinical and translational medicine. Projects completed this year include the following: a) Clinical Trials Database - a web-based tool for design, collecting, and reporting clinical observations related to natural history and interval-based studies. The total number of protocols supported by the CTDB grew 95, with an expansion of research questions to 35,000. Our software development group completed four major releases that included the following application features: a data coordinating center module for multi-site studies, a Java based web service to connect to the NLM Unified Medical Language System (UMLS) to obtain medical codes (SNOMED and LOINC), and software integration (Oracle 10g, Solaris 10, Java, Tomcat, and Apache). b) Biorepository Support - We created a Java-based barcode applet to allow PIs to print labels using the CTDB biorepository module completed for clinical sample tracking. The support team initiated a pilot phase for the Sample Tracking Module with multiple PIs at NICHD and NIDCR. c) Clinical Trial Survey System - This patient survey system was enhanced with three software releases, adding features for skip rules and PDA usage. The total enrollment was increased to 19 protocols. d) Clinical Datamart - we developed a star schema and reporting structure for research and hospital data integration. This design accomodates for clinical and genomic family history data, and biospecimens. The total number of protocol reports designed to 220. The team developed an integration with Cognos engine for additional reporting functionality and expanded existing CTDB Datamart with additional FACT tables. e) Clinical Wiki - we continued to advance the use of wiki tools for clinical research. Collaborative web portals were created for the OB/GYN services, pediatric endocrinology, biomedical education, and other DIR labs. BIOLOGICAL VISUALIZATION This student-led research area focuses on bilogical visualization. It was established this year to provide training opportunities for cross-disciple research in the areas of molecular animation, web programming, microscopy and digital imaging, and medical illustration. The student projects completed included the animation of the Golgi project in collaboration with J. Lippincott-Schwartz, who presented the work at the Golgi conference in Italy. A Golgi rapid prototype three dimensional model was created and accepted into the Golgi Museum in Pavia, Italy. The group redesigned and architected a new DIR Website based on the revised organizational structure of program areas. The team updated and maintained approximately 90 DIR websites, and developed graphic designs and medical illustrations for multiple projects: DIR annual retreat program, the GPP brochure for the Office of Education, DIR Annual Spring Research Festival, ClinicalTrial Tool Kit (CTK) brochure, and NICHD Summer Program t-shirt. The unit established a photography service for lab websites, including the documentation of microscopy techniques and assistance to the Microscopy Imaging Core (MIC) in with igital asset management tools. The team also expanded the science.nichd.nih.gov wiki to 30 projects. This tool allows PIs to create blogs, share documents/data in a secure manner. As part of this project, the group collaborated with the NIH Library to conduct a wiki workshop for NIH Intramural Investigators BIOINFORMATICS This research area collaborates with investigators to design and develop informatics applications for genomic research. Projects completed this year include the following: a) GermSAGE - This database and system manages a collection of male germ cell transcriptome information derived from Serial Analysis of Gene Expression (SAGE). The team developed a web-based application with features to view germ cell transcriptome data in the UCSC Genome Browser. Users can also search genes or specify searching criteria based on tag sequence, chromosomal location or tag counts. b) TransFragMap - Release 1.0 of this software was completed. This system provides a platform for executing bioinformatics scripts to map array data against genomes. c) Family History Genomic Tool - the unit developed this web-based system to assist investigators with the collecting disease patterns in patient families. This project involved the design and development of a unique pedigree reporting feature that accommodates multiple family structures. A pilot of the system is in progress with two DIR Investigators. RESEARCH AND MANAGEMENT INFORMATICS This software engineering core maintains and develops applications to assist investigators with the management of scientific resources and data. Projects completed this year include the following: a) MTrac - A web-based application that automates the clearance and approval process for manuscripts in the DIR. Seven major production releases were completed and the team provided user training and deployment to 5 DIR programs (PDN, PRAE, CBMP, PMM, and PCRM). The development team also completed a web service feature to connect to NLM Pubmed. b) Budget and Financial Systems - The unit created custom views for budgets, maintenance, backup, licensing support, user account management, and training for investigators. This included budget spreadsheets for usage during the DIR Budget Program Planning sessions and PI projections c)Personnel Systems - The team developed reports and maintained the code for staff management. The team also prepared requirements for proposed NIH Educational Tracking System. d) Administrative Datamart - The unit collected requirements for this proposed business intelligence tool that will allow PIs to analyze data from Personnel, Budget, MTrac and other admin systems. e) Software and Data Services - We established site licenses (e.g., EndNote, Reference Manager, Quosa) to assist investigators with publications and authorship. The group also worked with PIs to host applications, images, and files for scientific laboratory projects.

该项目是壁内研究部门的核心服务。 它重点是开发信息学工具，以支持多个研究人员和各种疾病领域。 信息系统和服务支持NIDCR，NINR，NIDCR，NIAMS，NIMH和NIDDK的其他计划的NICHD研究人员和研究人员。 临床信息学 该研究领域着重于临床和转化医学领域的应用和服务的开发。 今年完成的项目包括以下内容： a）临床试验数据库 - 一种基于网络的工具，用于设计，收集和报告与自然历史和基于间隔的研究有关的临床观察。 CTDB支持的协议总数增长了95，研究问题的扩展为35,000。 我们的软件开发小组完成了四个主要版本，其中包括以下应用程序功能：用于多站点研究的数据协调中心模块，一种基于Java的Web服务，可连接到NLM Unified医学语言系统（UMLS），以获取医疗法规（SNOMED和LOINC），以及软件集成（Oracle 10G，Solaris 10G，Solaris 10G，Solaris 10，Java，Java，Java，java，tomcat，tomCat，and Apache）。 b）生物座席支持 - 我们创建了一个基于Java的条形码小程序，以允许PI使用完成用于临床样品跟踪的CTDB BiorePository模块打印标签。 支持团队在NICHD和NIDCR上使用多个PI的样本跟踪模块启动了试点阶段。 c）临床试验调查系统 - 该患者调查系统通过三个软件版本增强，为跳过规则和PDA使用添加了功能。 总入学人数增加到19个方案。 d）临床数据摩 - 我们为研究和医院数据集成开发了星形架构和报告结构。 该设计可容纳临床和基因组家族史数据以及生物测量。 设计为220的协议报告的总数。该团队与Cognos Engine开发了一项集成，以提供其他报告功能，并通过其他事实表扩展了现有的CTDB DataMart。 e）临床Wiki-我们继续推动使用Wiki工具进行临床研究。 为OB/GYN服务，儿科内分泌学，生物医学教育和其他DIR实验室创建了协作网站。 生物可视化 该学生主导的研究领域的重点是双逻辑可视化。 今年成立的旨在为分子动画，网络编程，显微镜和数字成像以及医学插图的领域提供跨学科研究的培训机会。 完成的学生项目包括与J. Lippincott-Schwartz合作的Golgi Project的动画，后者在意大利的高尔基会议上介绍了这项工作。 Golgi快速原型三维模型被创建并接受到意大利帕维亚的高尔基博物馆。该小组根据计划领域修订的组织结构进行了重新设计并构建了一个新的DIR网站。 该团队更新并维护了大约90个DIR网站，并为多个项目开发了图形设计和医学插图：DIR年度撤退计划，教育办公室的GPP手册，DIR年度春季研究节，临床临床工具套件（CTK）手册和NICHD Summer Program T恤。 该部门为实验室网站建立了一项摄影服务，包括使用Igital Asset Management工具的显微镜技术文档和显微镜成像核心（MIC）的帮助。 该团队还将Science.nichd.nih.gov Wiki扩展到30个项目。 该工具允许PIS创建博客，以安全的方式共享文档/数据。 作为该项目的一部分，该小组与NIH图书馆合作，为NIH室内调查人员举办Wiki研讨会 生物信息学 该研究领域与研究人员合作设计和开发了基因组研究的信息学应用程序。 今年完成的项目包括以下内容： A）细菌 - 该数据库和系统管理源自基因表达（SAGE）序列分析的男性生殖细胞转录组信息。该团队开发了一个基于Web的应用程序，该应用程序具有可查看UCSC基因组浏览器中生殖细胞转录组数据的功能。 用户还可以根据标签序列，染色体位置或标签计数搜索基因或指定搜索条件。 b）TransFragMap-该软件的版本1.0已完成。 该系统提供了一个平台，用于执行生物信息学脚本以针对基因组映射数组数据。 C）家族史基因组工具 - 该单元开发了此基于网络的系统，以帮助研究人员在患者家庭中采用收集疾病模式。 该项目涉及设计和开发独特的谱系报告功能，可容纳多个家庭结构。 两名DIR调查人员正在进行该系统的飞行员。 研究与管理信息学 该软件工程核心维护和开发应用程序，以帮助调查人员管理科学资源和数据。 今年完成的项目包括以下内容： A）MTRAC-基于Web的应用程序，可自动使用DIR中手稿的清除和批准过程。完成了七个主要生产版本，该团队为5个DIR计划（PDN，PRAE，CBMP，PMM和PCRM）提供了用户培训和部署。 开发团队还完成了一个网络服务功能，可以连接到NLM PubMed。 b）预算和金融系统 - 该单元为预算，维护，备份，许可支持，用户帐户管理和调查人员培训创建自定义视图。 这包括在DIR预算计划计划和PI预测期间使用的预算电子表格 c）人事系统 - 团队开发了报告并维护了员工管理的代码。该团队还为拟议的NIH教育跟踪系统准备了要求。 d）行政数据玛 - 该单元收集了此拟议的商业智能工具的要求，该工具将允许PIS分析人员，预算，MTRAC和其他管理系统的数据。 e）软件和数据服务 - 我们建立了网站许可（例如，endnote，参考经理，Quosa），以协助调查人员获得出版物和作者身份。该小组还与PIS合作，为科学实验室项目托管应用程序，图像和文件。