Investigating neighborhood-environment contributions to midlife risk for dementia

调查邻里环境对中年痴呆风险的影响

基本信息

  • 批准号:
    10646205
  • 负责人:
  • 金额:
    $ 7.16万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-01 至 2025-07-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY / ABSTRACT Older adults living in disadvantaged neighborhoods, marked by poor physical, social, and economic conditions, are at elevated risk for dementia regardless of their personal sociodemographic characteristics. It is not yet clear when in the lifespan such risk emerges or through which putative causal mechanisms, if it is indeed causal. The activities proposed in this application will fill key research gaps in environmental health and geroscience through first-ever longitudinal studies of neighborhood characteristics and brain aging in midlife, when it is still possible to intervene to prevent dementia. They will inform the identification of at-risk individuals and significantly advance the evidence base needed for potential neighborhood-level dementia interventions, which could leverage public resources outside the healthcare sector and operate without requiring individual behavior change. Proposed projects will integrate diverse geospatial neighborhood data (housed at Michigan State University) into the four-decade archives of the Dunedin Study of psychosocial health, development, and aging among a population-representative New Zealand-based cohort born in 1972 and followed to midlife. The Dunedin cohort is the only one in the world with fine-grained measures of brain integrity from infancy to midlife, with the latest assessment (age 45) including brain structural and functional antecedents of dementia. Studies will determine: (1) whether individuals living in disadvantaged neighborhoods demonstrate signs of accelerated brain aging by midlife; (2) if specific neighborhood characteristics are uniquely associated with midlife brain- health deficits; and (3) whether pro-degenerative health behaviors and conditions (e.g., low physical activity, hypertension, etc.) and are more common in disadvantaged settings and thus may act as causal meditators. The applicant’s career goal is to become a clinical neuropsychologist and independent academic researcher who conducts public health-oriented research on the degenerative consequences of environmental exposures in the hopes of identifying modifiable risk factors and unique interventions to lower the global burden of brain disease. This fellowship will leverage a multi-university training plan to significantly advance the applicant’s career by allowing him to: (1) enter a PI-role in the Dunedin Study; (2) gain additional training to advance his unique research goals, including in established and cutting-edge methods in geospatial analysis, neurotoxicant assessment, and premorbid modeling of brain aging and dementia; and (3) prepare for an innovative career bridging environmental health and psychology with job-readiness skills in teaching, mentoring, and grant writing and management. Mentored training will occur in psychiatric, geospatial, and environmental epidemiology labs at Duke, Michigan State, and Harvard, supplemented by coursework, workshops, and conferences. The fellowship will ensure the applicant's move to independence for a unique body of work investigating environmental contributions to pathological brain aging, with future steps involving additional data linkage and assessment in older and younger cohorts and at the next assessment phase of the Dunedin Study.
项目概要/摘要 生活在贫困社区的老年人,身体、社会和经济条件较差, 无论个人的社会人口特征如何,他们患痴呆症的风险都很高。 明确这种风险在生命周期中何时出现,或者通过哪种假定的因果机制(如果确实如此) 本申请中提出的活动将填补环境健康和环境方面的关键研究空白。 通过对中年邻里特征和大脑衰老的首次纵向研究进行老年科学, 当仍然有可能进行干预以预防痴呆症时,他们将告知高危人群的识别。 并显着推进潜在的社区级痴呆症干预措施所需的证据基础, 它可以利用医疗保健部门以外的公共资源,并且无需个人参与即可运作 拟议的项目将整合不同的地理空间邻里数据(位于密歇根州)。 州立大学)将其纳入但尼丁心理健康、发展和社会研究的四个十年档案中 新西兰 1972 年出生并一直持续到中年的人群的老龄化情况。 但尼丁队列是世界上唯一一个对从婴儿期到中年的大脑完整性进行细粒度测量的队列, 最新评估(45 岁)包括痴呆症的大脑结构和功能前因研究。 将确定:(1)生活在贫困社区的个人是否表现出加速迹象 中年大脑老化;(2)特定的邻里特征是否与中年大脑独特相关 健康缺陷;以及 (3) 是否存在促退化的健康行为和状况(例如体力活动不足、 高血压等),并且在弱势环境中更为常见,因此可以作为因果冥想者。 申请人的职业目标是成为一名临床神经心理学家和独立学术研究员 世卫组织对环境暴露的退化后果进行公共卫生导向的研究 希望确定可改变的风险因素和独特的干预措施,以减轻全球大脑负担 该奖学金将利用多大学培训计划来显着提高申请人的水平。 通过允许他:(1) 在但尼丁研究中担任 PI 角色,(2) 获得额外培训以提升自己的职业生涯; 独特的研究目标,包括地理空间分析、神经毒物等方面的既定和前沿方法 大脑衰老和痴呆症的评估和病前建模;(3) 为创新职业做好准备; 将环境健康和心理学与教学、指导和资助方面的就业准备技能联系起来 写作和管理方面的指导培训将进行。 杜克大学、密歇根州立大学和哈佛大学的流行病学实验室,辅以课程作业、研讨会和 该奖学金将确保申请人独立从事独特的工作。 研究环境对病理性大脑老化的影响,未来的步骤涉及更多数据 在较老和较年轻的队列中以及达尼丁研究的下一个评估阶段进行联系和评估。

项目成果

期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Who tests for lead and why? A 10-year analysis of blood lead screening, follow-up and CNS outcomes in a statewide US healthcare system.
谁测试铅含量以及为什么?
  • DOI:
  • 发表时间:
    2024-02-02
  • 期刊:
  • 影响因子:
    4.9
  • 作者:
    Reuben, Aaron;Ward, Ralph;Rothbaum, Alex O;Cornelison, Vickey L;Huffman, Sarah;McTeague, Lisa M;Schmidt, Michael G;Specht, Aaron J;Kilpatrick, Dean G
  • 通讯作者:
    Kilpatrick, Dean G
Prevalence of Depression and Posttraumatic Stress Disorder in Flint, Michigan, 5 Years After the Onset of the Water Crisis.
水危机爆发五年后密歇根州弗林特抑郁症和创伤后应激障碍的患病率。
  • DOI:
  • 发表时间:
    2022-09-01
  • 期刊:
  • 影响因子:
    13.8
  • 作者:
    Reuben, Aaron;Moreland, Angela;Abdalla, Salma M;Cohen, Gregory H;Friedman, Matthew J;Galea, Sandro;Rothbaum, Alex O;Schmidt, Michael G;Vena, John E;Kilpatrick, Dean G
  • 通讯作者:
    Kilpatrick, Dean G
Association of Public Works Disasters with Substance Use Difficulties: Evidence from Flint, Michigan, Five Years after the Water Crisis Onset.
公共工程灾难与物质使用困难的协会:来自密歇根州弗林特的水危机爆发五年后的证据。
  • DOI:
  • 发表时间:
    2023-11-21
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Onookome;Hsu, Angel;Kilpatrick, Dean G;Moreland, Angela;Reuben, Aaron
  • 通讯作者:
    Reuben, Aaron
Improving risk indexes for Alzheimer's disease and related dementias for use in midlife.
改善中年阿尔茨海默病和相关痴呆症的风险指数。
  • DOI:
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    4.8
  • 作者:
    Reuben, Aaron;Moffitt, Terrie E;Abraham, Wickliffe C;Ambler, Antony;Elliott, Maxwell L;Hariri, Ahmad R;Harrington, Honalee;Hogan, Sean;Houts, Renate M;Ireland, David;Knodt, Annchen R;Leung, Joan;Pearson, Amber;Poulton, Richie;Purdy, Suzanne
  • 通讯作者:
    Purdy, Suzanne
Quantifying Nature: Introducing NatureScoreTM and NatureDoseTM as Health Analysis and Promotion Tools.
量化自然:引入 NatureScoreTM 和 NatureDoseTM 作为健康分析和推广工具。
  • DOI:
  • 发表时间:
    2024-01
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Browning, Matthew H E M;Hanley, Jared R;Bailey, Christopher R;Beatley, Timothy;Gailey, Samantha;Hipp, J Aaron;Larson, Lincoln R;James, Peter;Jennings, Viniece;Jimenez, Marcia Pescador;Kahn Jr, Peter H;Li, Dongying;Reuben, Aaron;Rigolon, Aless
  • 通讯作者:
    Rigolon, Aless
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Aaron Reuben其他文献

Aaron Reuben的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Aaron Reuben', 18)}}的其他基金

Investigating neighborhood-environment contributions to midlife risk for dementia
调查邻里环境对中年痴呆风险的影响
  • 批准号:
    10457188
  • 财政年份:
    2022
  • 资助金额:
    $ 7.16万
  • 项目类别:

相似国自然基金

TBX20在致盲性老化相关疾病年龄相关性黄斑变性中的作用和机制研究
  • 批准号:
    82220108016
  • 批准年份:
    2022
  • 资助金额:
    252 万元
  • 项目类别:
    国际(地区)合作与交流项目
LncRNA ALB调控LC3B活化及自噬在体外再生晶状体老化及年龄相关性白内障发病中的作用及机制研究
  • 批准号:
    81800806
  • 批准年份:
    2018
  • 资助金额:
    22.0 万元
  • 项目类别:
    青年科学基金项目
APE1调控晶状体上皮细胞老化在年龄相关性白内障发病中的作用及机制研究
  • 批准号:
    81700824
  • 批准年份:
    2017
  • 资助金额:
    19.0 万元
  • 项目类别:
    青年科学基金项目
KDM4A调控平滑肌细胞自噬在年龄相关性血管老化中的作用及机制
  • 批准号:
    81670269
  • 批准年份:
    2016
  • 资助金额:
    55.0 万元
  • 项目类别:
    面上项目
A2E老化ARMS2/HTRA1型iPSC-RPE细胞的研究:个体化AMD发病机制初步探索
  • 批准号:
    81400412
  • 批准年份:
    2014
  • 资助金额:
    25.0 万元
  • 项目类别:
    青年科学基金项目

相似海外基金

Individual Predoctoral Fellowship
个人博士前奖学金
  • 批准号:
    10752036
  • 财政年份:
    2024
  • 资助金额:
    $ 7.16万
  • 项目类别:
The Proactive and Reactive Neuromechanics of Instability in Aging and Dementia with Lewy Bodies
衰老和路易体痴呆中不稳定的主动和反应神经力学
  • 批准号:
    10749539
  • 财政年份:
    2024
  • 资助金额:
    $ 7.16万
  • 项目类别:
Interrogating the role of m6A mRNA methylation in the aging of the β-cell and diabetes
探讨 m6A mRNA 甲基化在 β 细胞衰老和糖尿病中的作用
  • 批准号:
    10644215
  • 财政年份:
    2023
  • 资助金额:
    $ 7.16万
  • 项目类别:
Using Tailored mHealth Strategies to Promote Weight Management among Adolescent and Young Adult Cancer Survivors
使用量身定制的移动健康策略促进青少年和年轻癌症幸存者的体重管理
  • 批准号:
    10650648
  • 财政年份:
    2023
  • 资助金额:
    $ 7.16万
  • 项目类别:
The role of adverse community-level policing exposure on disparities in Alzheimer's disease related dementias and deleterious multidimensional aging
社区层面的不良警务暴露对阿尔茨海默病相关痴呆和有害的多维衰老差异的作用
  • 批准号:
    10642517
  • 财政年份:
    2023
  • 资助金额:
    $ 7.16万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了