The Use of Virtual Reality to Discover Objective Correlates of Alcohol Craving

使用虚拟现实来发现酒精渴望的客观关联

• 批准号: 10652931
• 负责人: Kelly Elizabeth Courtney
• 金额: $ 18.76万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10652931
• 关键词: Adult; Alcohol consumption; Alcoholic beverage heavy drinker; Alcohols; Attention; Awareness; Basic Science; Biological Markers; Blinking; Clinical; Clinical Sciences; Clinical Trials; Cognitive; Conscious; Corpus striatum structure; Cues; Development; Dopamine; Environment; Exhibits; Foundations; Future; Goals; Guidelines; Intervention; Investigation; Laboratories; Maintenance; Measurement; Measures; Methods; National Institute on Alcohol Abuse and Alcoholism; Nature; Participant; Pathogenesis; Patient Self-Report; Pharmaceutical Preparations; Pharmacological Treatment; Phenotype; Process; Psychophysiology; Reporting; Research; Sampling; Science; Technology; Telephone; Testing; Time; Treatment outcome; Validation; Visual; addiction; alcohol abuse therapy; alcohol craving; alcohol cue; alcohol exposure; attentional bias; clinically relevant; craving; cue reactivity; effective therapy; experience; feasibility testing; follow-up; improved; innovation; interest; novel; psychobiologic; psychologic; response; smartphone based assessment; substance use; therapy development; virtual reality; virtual reality environment; visual tracking

PROJECT SUMMARY The study of craving for alcohol and drugs is increasingly thought to be essential for understanding the pathogenesis and maintenance of addiction. However, valid and reliable methods for investigating this psychobiologic phenomenon are lacking. This study seeks to develop a novel, ecologically valid paradigm that capitalizes on the technological advances and realism of virtual reality (VR) to both induce alcohol craving, via presentation of realistic alcohol-related cues, and reliably assess alcohol craving, via measurement of potential craving correlates (attentional bias and spontaneous eye-blink rate [EBR]) and subjective reports. Following initial acceptability testing and optimization (n=15), three alcohol active and three neutral VR scenes will be administered to a sample comprised of low-moderate alcohol drinkers (n=50) and heavy alcohol drinkers (n=50). Eye-tracking (to establish attentional bias towards alcohol cues) and EBR will be continuously recorded during presentation of the scenes. Participants will then be followed for seven-days, via mobile assessment, and contacted by phone at day 30, to obtain self-report responses of subjective alcohol craving and alcohol use in their naturalistic environment. Thus, the specific aims of the proposed research are: (1) to develop an ecologically valid and immersive VR cue-reactivity paradigm that reliably induces alcohol craving, (2) test the feasibility, reliability, and utility of VR derived attentional bias as an objective craving correlate by comparing it against commonly used measures of subjective craving and attentional bias, and (3) examine the predictive utility of the objective correlates of alcohol craving acquired during the paradigm and subjective reports of alcohol craving and alcohol use during follow-up. The use of EBR as an objective craving correlate will also be investigated as an exploratory aim. Once fully developed and tested, this paradigm will have tremendous applications within basic science research on alcohol craving and within clinical science via providing a new platform to develop interventions that aim to reduce craving. Further, this project will advance our understanding of attentional bias and its utility as a predictive measure of alcohol craving and use.

项目概要 人们越来越认为，对酒精和毒品的渴望的研究对于理解酒精和毒品的渴望至关重要。 成瘾的发病机制和维持。然而，调查这一问题的有效且可靠的方法 缺乏心理生物学现象。本研究旨在开发一种新颖的、生态上有效的范式 利用虚拟现实 (VR) 的技术进步和真实感来诱发酒精渴望，通过 呈现真实的酒精相关线索，并通过测量潜力可靠地评估酒精渴望 渴望相关（注意力偏差和自发眨眼率[EBR]）和主观报告。下列的 初始可接受性测试和优化（n = 15），三个酒精活性和三个中性 VR 场景将被 受试者为中低度饮酒者 (n=50) 和重度饮酒者 （n=50）。眼球追踪（以建立对酒精线索的注意力偏差）和 EBR 将被持续记录 在场景呈现过程中。然后将通过移动评估对参与者进行为期 7 天的跟踪， 在第 30 天通过电话联系，以获得主观酒精渴望和酒精的自我报告反应 在自然环境中使用。 因此，本研究的具体目标是：（1）开发一种生态有效且身临其境的环境。 可靠地诱发酒精渴望的 VR 线索反应范式，(2) 测试可行性、可靠性和实用性 VR 通过将注意力偏差与常用的测量方法进行比较，得出了作为客观渴望相关性的注意力偏差 主观渴望和注意力偏差的影响，以及（3）检查客观相关因素的预测效用 范式期间获得的酒精渴望以及酒精渴望和饮酒期间的主观报告 后续行动。使用 EBR 作为客观渴望相关因素也将作为一个探索性目标进行研究。 一旦完全开发和测试，这种范式将在基础科学领域具有巨大的应用 通过提供新的平台来开发干预措施，对酒精渴望和临床科学进行研究 旨在减少渴望。此外，该项目将增进我们对注意力偏差及其效用的理解 作为酒精渴望和使用的预测指标。