Magnesium and Calcium Metabolism In Humans And Biological Systems

人体和生物系统中镁和钙的代谢

• 批准号: 7733625
• 负责人: NADJA REHAK
• 金额: $ 1.19万
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7733625
• 关键词: 1,25 (OH) vitamin D; Adult; Affect; Biological; Blood specimen; Calcium; Calcium Chloride; Chemicals; Homeostasis; Hormones; Hour; Human; Hypoparathyroidism; Informed Consent; Infusion procedures; Kidney; Link; Magnesium; Mixed Function Oxygenases; Parathyroid Hormones; Phosphorus; Production; Purpose; Serum; System; Time; Tubular formation; Vitamin D; Vitamins; calcium metabolism; fibroblast growth factor 23; human PTH protein; inorganic phosphate; intravenous administration; novel

Seven hyperphosphatemic hypoparathyroid adult subject gave informed consent to participate in the 72-hour study during which there was an 8 hour intravenous infusion of calcium chloride followed by a 16 hour washout. During the study serial blood samples were collected for chemical analysis. In four subjects there was a significant increase (up to 200%) in serum FGF-23 within the first 24 hours following the calcium chloride infusion during which the serum ionized calcium increased (mean difference 0.38 mmol/L) and serum ionized magnesium decreased ( mean difference 0.09 mmol/L). In addition, there was also a significant (approximately 25%) increase in serum phosphorus. In three subjects that were pre-treated with PTH the infusion of calcium chloride did not affect the serum P and FGF-23 concentrations. These preliminary results indicate that the serum FGF-23 concentration is regulated by changes in serum P and not vitamin 1,25-D.

七个高磷酸血压甲状腺功能低下成人受试者给予了知情同意，参加了72小时的研究，在此期间，静脉注射8小时，然后进行8小时的氯化钙输注，然后进行16小时的清洗。在研究期间，收集了系列血样进行化学分析。 在四名受试者中，在氯化钙输注后的前24小时内，血清FGF-23显着增加（高达200％），在此期间，血清离子化钙增加（平均差0.38 mmol/L）和血清离子化镁减少（平均差异0.09 mmol/L）。此外，血清磷的增加（约25％）。在用PTH预处理的三个受试者中，氯化钙的输注不会影响血清P和FGF-23浓度。 这些初步结果表明，血清FGF-23浓度受血清P的变化而不是维生素1,25-D调节。

项目成果

Effects of interleukin 2 therapy on lymphocyte magnesium levels.

白细胞介素 2 治疗对淋巴细胞镁水平的影响。

• DOI: 10.1067/mlc.2002.120361
• 发表时间: 2002
• 期刊: The Journal of laboratory and clinical medicine
• 作者: McKee,MarkD;Cecco,StaceyA;Niemela,JulieE;Cormier,Janice;Kim,ChristinaJ;Steinberg,SethM;Rehak,NadjaN;Elin,RonaldJ;Rosenberg,StevenA
• 通讯作者: Rosenberg,StevenA