ERC Einstein Rockefeller CUNY Center for AIDS Research

ERC 爱因斯坦洛克菲勒纽约市立大学艾滋病研究中心

基本信息

批准号：
10605270
负责人：
Joan Weinberger Berman
金额：
$ 35.96万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-01 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10605270
关键词：
Acceleration Acquired Immunodeficiency Syndrome Animal Model Anti-Retroviral Agents Antigens Antiviral Agents Articulation Biochemical Bioinformatics Biological Assay Biological Markers Biological Products Biology Blood Body Fluids Brain Cell Culture Techniques Cell Separation Cells Cellular Immunity Characteristics Clinical Clinical Sciences Collaborations Consultations DNA Development Drug Kinetics Effectiveness Enzyme-Linked Immunosorbent Assay Epidemic Freezing Future Goals HIV HIV Infections HIV risk HIV/AIDS Human Humoral Immunities Immune Immunotherapy In Vitro Infrastructure Insecta Institution Knowledge Leadership Life Cycle Stages Ligands Link Liquid substance Macrophage Mass Spectrum Analysis Measurement Mental Health Mentors Mentorship Modeling Participant Pathogenesis Patients Peripheral Blood Mononuclear Cell Persons Pharmaceutical Preparations Pharmacodynamics Prevention approach Process Production Prophylactic treatment Proteins Proteomics RNA Reagent Research Research Personnel Resources Risk Sampling Science Services Technology Therapeutic Training Translational Research Vaccines Viral Virus antibody-dependent cell cytotoxicity antiretroviral therapy biomarker performance cell type comorbidity experience forging implementation research improved in vivo innovative technologies medication compliance member metabolomics microbiome analysis monocyte new technology next generation novel novel strategies pre-exposure prophylaxis prevent programs receptor recruit response small molecule synergism therapy adherence tissue culture transcriptomics treatment as prevention working group

项目摘要

PROJECT SUMMARY ERC-CFAR: BIOMARKER AND ADVANCED TECHNOLOGY CORE (BATC) To support the overarching goal of the ERC-CFAR to end the HIV epidemic, the Biomarker and Advanced Technology Core (BATC) provides state-of-the-art technologies, services and consultations to enhance our understanding of HIV biology and mechanisms and accelerate the development of novel approaches for prevention and cure. The BATC supports implementation research to improve the effectiveness of pre-exposure prophylaxis (PrEP), post-exposure prophylaxis (PEP) and treatment as prevention (TasP). The BATC infrastructure supports established and early stage HIV/AIDS researchers as well as new investigators who are expanding their research to include HIV/AIDS-related studies at Einstein, Rockefeller, and CUNY. The leadership provides unique consultation services that leverage their experience to identify opportunities within and outside the BATC. The BATC provides cutting-edge services for our investigators and members of the HIV and Mental Health Scientific Working Group to accomplish their research, mentors and trains the next generation of HIV investigators, recruits established investigators into HIV research, and forges new collaborations across Einstein, Rockefeller and CUNY and other regional academic centers. The Aims of the BATC are: 1) Provide investigators with technological support to examine and evaluate novel approaches to prevent, treat and cure HIV infection and to characterize HIV pathogenesis. The BATC provides a wide array of services including biomarker assays and measurement of antiretroviral drug adherence, which are critical for PrEP, PEP and TasP studies. The BATC analyzes body fluids, culture supernatants and cell lysates for immune molecules and antiviral drug pharmacokinetics/pharmacodynamics using high-throughput multiplex platforms, ELISAs, and mass spectrometry. The BATC provides isolated cell types from human leukopaks and from blood from people with HIV (PWH). The BATC serves as a liaison with the Clinical and Translational Science Core to process blood from PWH leukapharesed at Einstein or Rockefeller to isolate and freeze various cell types for future use by ERC-CFAR investigators. The BATC will customize assays for HIV RNA/DNA quantification and import and establish cutting edge technologies; 2) Provide investigators with state-of-the-art technologies in the Protein Sciences to support studies of HIV biology, mechanism, and treatment. The BATC provides critical protein reagents for development of novel biologics for HIV eradication, protein antigens to study cellular and humoral immunity, and large quantities of materials for structural and biochemical characterization of proteins and assemblies critical for HIV infection and life cycle. It provides unique cell-based assays to characterize receptor-ligand interactions, including those linked to antibody dependent cell mediated cytotoxicity, a critical aspect of vaccines and immunotherapies; 3) Implement and evaluate the utility and feasibility of new technologies for inclusion within BATC. The BATC implemented bioinformatics services and is evaluating new technologies for inclusion within the BATC, including metabolomics and proteomics.

项目摘要 ERC-CFAR：生物标志物和先进技术核心（BATC）为了支持ERC-CFAR的总体目标，以结束艾滋病毒流行，生物标志物和先进技术核心（BATC）提供最先进的技术，服务和咨询，以增强我们的了解艾滋病毒生物学和机制，并加速新方法的发展防治。 BATC支持实施研究以提高暴露前的有效性预防（PREP），暴露后预防（PEP）和治疗作为预防（TASP）。 BATC 基础设施支持已建立和早期的艾滋病毒/艾滋病研究人员以及新的研究人员扩大他们的研究，包括爱因斯坦，洛克菲勒和CUNY的HIV/AIDS相关研究。领导提供独特的咨询服务，以利用他们的经验来确定内部和外部的机会 BATC。 BATC为我们的调查人员和艾滋病毒和心理的成员提供最先进的服务健康科学工作组完成他们的研究，指导和培训下一代艾滋病毒研究人员，招募人员为艾滋病毒研究建立了研究人员，并在爱因斯坦进行了新的合作，洛克菲勒和CUNY以及其他地区学术中心。 BATC的目的是：1）提供具有技术支持的研究人员，以检查和评估预防，治疗和治疗的新方法治愈HIV感染并表征HIV发病机理。 BATC提供了各种各样的服务包括生物标志物测定和抗逆转录病毒药物依从性的测量，这对于PEP，PEP至关重要和TASP研究。 BATC分析人体流体，培养上清液和细胞裂解物的免疫分子使用高通量多重平台，ELISA和质谱法。 BATC从人类leukopaks和人的血液中提供孤立的细胞类型与艾滋病毒（PWH）。 BATC是与临床和转化科学核心的联络从爱因斯坦（Einstein）或洛克菲勒（Rockefeller ERC-CFAR调查人员。 BATC将自定义HIV RNA/DNA量化和进口的测定法和建立最先进的技术； 2）为调查人员提供最先进的技术蛋白质科学支持HIV生物学，机制和治疗的研究。 BATC提供了关键用于开发新生物制剂的蛋白质试剂，用于消除HIV，蛋白质抗原，以研究细胞和蛋白质的结构和生化表征的体液免疫和大量材料和组件对于艾滋病毒感染和生命周期至关重要。它提供了独特的基于单元的测定法来表征受体配体相互作用，包括与抗体依赖性细胞介导的细胞毒性相关的相互作用，一种关键疫苗和免疫疗法的方面； 3）实施和评估新的实用性和可行性纳入BATC的技术。 BATC实施了生物信息学服务，是评估包括代谢组学和蛋白质组学在内的NEW TECHALICES包含在BATC中。