Sensory Prediction in the Auditory Cortex during Vocal Production

发声过程中听觉皮层的感觉预测

• 批准号: 10619016
• 负责人: STEVEN J ELIADES
• 金额: $ 39.67万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10619016
• 关键词: Acoustics; Address; Animals; Area; Auditory; Auditory area; Auditory system; Behavior; Behavior Control; Behavioral; Callithrix; Callithrix jacchus jacchus; Code; Communication impairment; Compensation; Dorsal; Exhibits; Feedback; Frequencies; Goals; Hearing; Human; Life; Link; Location; Measures; Modality; Modeling; Monitor; Monkeys; Motor; Neurons; Pathway interactions; Play; Primates; Process; Production; Research; Role; Sensory; Shapes; Signal Transduction; Site; Speech; Stimulus; Structure; Testing; Time; Voice; Work; auditory pathway; experimental study; hearing impairment; insight; neural; neural circuit; neuromechanism; novel; novel strategies; pharmacologic; response; sensory cortex; sensory feedback; sensory input; sensory integration; sensory mechanism; sound; vocal control; vocalization

The overall objective of this research is to understand the role of sensory prediction in the auditory cortex. The ability to predict the sensory consequences of one’s actions plays an important role in shaping sensory coding and guiding behavior. In the auditory system, this prediction is used during vocal production, allowing us to monitor feedback of the sound of our voice. However, the neural mechanisms of this auditory self-monitoring are unknown. This proposal focuses on determining the mechanisms and neural circuits by which sensory prediction changes sensory coding in the auditory cortex during vocalization, and the behavioral role played by such predictions. We approach this using a novel vocal primate model, the marmoset monkey. Aim 1 focuses on the mechanisms of feedback encoding during vocalization, and tests the hypothesis that sensory prediction shapes auditory cortex responses to calculate an error signal between vocal feedback and the prediction. We record auditory cortex neurons in vocalizing marmosets while adjusting the frequency content of their vocal feedback using frequency shifts of varying direction and magnitude to measure sensitivity to feedback errors. To further investigate potential computational mechanisms by which sensory prediction shapes feedback coding, we measure frequency tuning changes in auditory cortex during vocalization compared to passive listening, and how these relate to predicted vocal acoustics. Aim 2 investigates the auditory cortical circuits involved in sensory prediction and feedback encoding, testing the hypothesis that the dorsal auditory pathway exhibits greater feedback sensitivity than early auditory cortex. We record responses to altered feedback during vocalization and compare responses between the dorsal “where and how” pathway with primary auditory cortex (A1) and the ventral “what” pathway. We further compare the strength of neural activity in predicting compensatory vocal changes during altered feedback. These results have important implications for validating current models of functional specializations within these higher-order auditory pathways. Aim 3 addresses the behavioral role of sensory prediction in auditory cortex, testing the hypothesis that activity within the auditory cortex is necessary for feedback-dependent vocal control. We combine frequency- shifted vocal feedback with pharmacologic inactivation of auditory cortex to determine if such manipulations disrupt behavioral compensation. We further compare effects of inactivation between hemispheres and sites of different frequency tuning. These experiments will demonstrate a causal role for the auditory cortex in feedback self-monitoring and resulting vocal control.

这项研究的总体目的是了解感觉预测在听觉中的作用 皮质。预测一个人行为的感官后果的能力在塑造中起着重要作用 感觉编码和指导行为。在听觉系统中，该预测在人声制作过程中使用， 允许我们监视声音的反馈。但是，该听觉的神经机制 自我监控是未知的。该提案着重于确定通过 在发声过程中，哪些感觉预测改变了听觉皮层中的感觉编码，行为 通过这种预测扮演的角色。我们使用一种新颖的人声私人模型The Marmoset Monkey来解决此问题。 AIM 1专注于发声过程中反馈编码的机制，并检验假设 感官预测塑造了听觉皮层的响应，以计算声音反馈之间的错误信号 和预测。我们在调整频率的同时记录了听觉皮层神经元在发声的声音中 使用不同方向和幅度的频移以测量灵敏度的频率转移的内容 反馈错误。为了进一步研究潜在的计算机制，感官预测 形状反馈编码，我们测量发声过程中听觉皮层的频率调整变化 与被动聆听相比，以及这些与预测的声音声学之间的关系。 AIM 2研究了参与感官预测和反馈编码的听觉皮层电路， 测试背侧听觉途径比早期听觉表现出更大的反馈灵敏度的假设 皮质。我们记录了在发声过程中对反馈改变的反应，并比较 主听觉皮层（A1）和腹侧“ What”途径的背面“何处和如何”路径。我们进一步 比较在反馈改变过程中预测补偿性声音变化时神经活动的强度。 这些结果对于验证当前功能专业模型具有重要意义 这些高阶听觉途径。 AIM 3解决了感觉预测在听觉皮层中的行为作用，检验了以下假设。 听觉皮层内的活动对于反馈依赖性的人声控制是必需的。我们结合了频率 - 通过对听觉皮层的药物失活的转移声反馈，以确定这种操纵是否存在 破坏行为补偿。我们进一步比较了半球和位点之间失活的影响 不同的频率调整。这些实验将证明听觉皮层在 反馈自我监控和由此产生的声音控制。