Poxvirus pathogenesis and immunity

痘病毒发病机制和免疫

• 批准号: 7732631
• 负责人: BERNARD MOSS
• 金额: $ 93.73万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732631
• 关键词: Adult; Africa; Animals; Benign; Biological; Complex; DNA Viruses; Family; Fright; Genes; Goals; Human; Immune; Immunity; Immunocompetent; Infant; Lesion; Molluscum contagiosum virus; Monkeypox; Monkeypox virus; Numbers; Orthopoxvirus; Pathogenesis; Poxviridae; Purpose; Skin; Smallpox; Smallpox Vaccine; Smallpox Viruses; Vaccinia virus; Virulence; Widespread Disease; Zoonoses; base; human mortality; interest; invertebrate host; member; pathogen

Poxviruses comprise a large family of complex DNA viruses that have vertebrate and invertebrate hosts. Two poxviruses, variola virus and molluscum contagiosum virus, are specific human pathogens. Variola virus was the cause of smallpox until the latter was eradicated but is still feared because of potential use a biological weapon. Molluscum contagiosum virus causes benign skin lesions in immunocompetent infants and a more severe and widespread disease in immunodeficient adults. In addition, several animal poxviruses can be transmitted to humans as zoonosis. The most serious of these is monkeypox, which has an estimated human mortality of about 10%. The poxviruses express a large number of host immune evasion genes that contribute to virulence. The purpose of this project is to increase our understanding of poxvirus pathogenesis and the basis for immunity to poxviruses.

痘病毒由脊椎动物和无脊椎动物宿主的大型复杂DNA病毒组成。两种痘病毒是特定的人类病原体。 Variola病毒是天花的原因，直到消除后者，但由于潜在使用生物武器而被恐惧。软体动物胃肠菌病毒会导致免疫能力婴儿的良性皮肤病变，并在免疫缺陷的成年人中更严重，更广泛的疾病。此外，可以将几种动物痘病毒传播给人类病。其中最严重的是Monkeypox，其人类死亡率约为10％。痘病毒表达了大量导致毒力的宿主免疫逃避基因。该项目的目的是增加我们对痘病毒发病机理的理解和对痘病毒免疫的基础。

项目成果

Vaccinia virus entry/fusion complex subunit A28 is a target of neutralizing and protective antibodies.

• DOI: 10.1016/j.virol.2008.08.009
• 发表时间: 2008-10-25
• 期刊: VIROLOGY
• 影响因子: 3.7
• 作者: Nelson, Gretchen E.;Sisler, Jerry R.;Chandran, Dev;Moss, Bernard
• 通讯作者: Moss, Bernard