Development of a PEM-PET-CT Breast Imaging and Biopsy Device

PEM-PET-CT 乳腺成像和活检设备的开发

• 批准号: 7590070
• 负责人: RAYMOND ROBERT RAYLMAN
• 金额: $ 50.19万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7590070
• 关键词: Address; Adjuvant Chemotherapy; Algorithms; Area; Biopsy; Breast; Breast Fibrocystic Disease; Caring; Characteristics; Clinical; Clinical Research; Complement; Computer Systems; Computer software; Coupled; Data; Detection; Development; Devices; Diagnosis; Diagnostic; Dose; Effectiveness; Elements; Event; Future; Goals; Head; Human; Image; Image Guided Biopsy; Imaging Techniques; Investigation; Lesion; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Mammography; Measures; Medical Imaging; Methodology; Methods; Modality; Modification; Organ; Partner in relationship; Performance; Photons; Physiological Processes; Positioning Attribute; Positron; Positron-Emission Tomography; Process; Protocols documentation; Radial; Radiation; Radioisotopes; Relative (related person); Resolution; Retinal Cone; Risk Factors; Role; Rotation; Running; Scanning; Scheme; Second Look Surgery; Staging; System; Techniques; Testing; Three-Dimensional Imaging; Time; Tissues; Tomography, Computed, Scanners; United States National Institutes of Health; Woman; X-Ray Computed Tomography; attenuation; breast lesion; breast scanner; calcification; cancer diagnosis; cancer therapy; chemotherapy; cone-beam computed tomography; data acquisition; detector; flexibility; image reconstruction; imaging modality; improved; interest; malignant breast neoplasm; minimally invasive; new technology; public health relevance; radiation absorbed dose; radiotracer; reconstruction; software development; tomography; trend; trial comparing; tumor; whole body imaging

DESCRIPTION (provided by applicant): Positron emission tomography (PET) breast imaging can potentially improve the detection and diagnosis of cancer in women with radiodense and/or fibrocystic breasts. Additionally, the quantitative capabilities afforded by PET may also be exploited to provide early and accurate assessment of cancer treatment. During the last four years, our group, with the support of the National Institutes of Health, have developed a high-resolution positron emission mammography and tomography imaging and biopsy device (called PEM-PET) to detect and guide the biopsy of suspicious breast lesions, and quantify radionuclide concentrations in tissue. The system consists of two sets of rotating planar detector heads. Each detector head consists of a 4x3 array of Hamamatsu H8500 flat panel position sensitive photomultipliers (PSPMTs) coupled to a 96W72 array of 2W2W15mm3 LYSO detector elements (pitch= 2.1mm). Image reconstruction is performed with a 3D-OSEM algorithm optimized to run on an eight CPU computer system, significantly reducing image reconstruction times. Initial testing of the device is focusing yielded a spatial resolution at the center of the FOV of 1.87mm (radial), 1.84mm (tangential) and 1.67mm (axial); at 7cm from the center, the results were 1.9mm (radial), 1.89mm (tangential) and 1.69mm (axial). Total system detection sensitivity is 363.3kcps/microcurie/ml. In the continuing development of our breast imaging and biopsy system we propose the further optimization of the PET system; addressing some areas of weakness (count rate performance, for example) identified in our initial testing regime. We also propose the addition of a cone beam, x-ray computed tomography (CT) scanner to the current PEM-PET system, creating the PEM-PET-CT breast imaging and biopsy device. PEM-PET-CT will have the unique ability to continuously rotate during data acquisition, permitting the ability to rapidly produce PET and CT images. The anatomical information gained by integration of the CT imager will permit the correlation of structural features of the breast and abnormal areas with functional information from these areas. Thus, the two methods complement each other well. The data provided by the CT images will also be used improve corrections for physical phenomena that can confound quantitative measures of radiotracer concentrations. Finally, the completed system be tested in these two application during a pilot human trial, comparing its performance to whole body PET, MRI and MRS. The data from these studies will be crucial in the planning of future larger human trials. We envision that PEM-PET-CT could be used to detect lesions in women with dense breasts and indeterminate mammograms that have additional risks factors for cancer. It could also be used in the diagnostic role as a "second look" method to assess suspicious lesions or micro- calcifications. Lastly, the unique quantitative capabilities of the system could facilitate its use in treatment assessment of chemotherapy, especially in small tumors. Thus, the development of this new multi-modality system is a unique opportunity to improve a number of important clinical aspects of breast care. PUBLIC HEALTH RELEVANCE This application proposes the continued development of a dedicated breast PET-CT system. This device could be instrumental in the detection, diagnosis and treatment assessment of breast cancer.

描述（由申请人提供）：正电子发射断层扫描（PET）乳腺成像可以潜在地改善具有放射致密和/或纤维囊性乳房的女性的癌症检测和诊断。此外，PET 提供的定量能力还可用于提供癌症治疗的早期、准确评估。在过去的四年里，我们小组在美国国立卫生研究院的支持下，开发了一种高分辨率正电子发射乳房X线摄影和断层扫描成像和活检装置（称为PEM-PET），用于检测和指导可疑乳腺病变的活检，并量化组织中的放射性核素浓度。该系统由两组旋转平面探测器头组成。每个探测器头由一个 4x3 阵列的 Hamamatsu H8500 平板位置敏感光电倍增管 (PSPMT) 组成，该阵列耦合到一个 96W72 阵列的 2W2W15mm3 LYSO 探测器元件（间距 = 2.1mm）。图像重建采用 3D-OSEM 算法进行优化，可在八个 CPU 计算机系统上运行，从而显着减少图像重建时间。该设备的初始聚焦测试在视场中心产生了 1.87 毫米（径向）、1.84 毫米（切向）和 1.67 毫米（轴向）的空间分辨率；在距中心 7 厘米处，结果为 1.9 毫米（径向）、1.89 毫米（切向）和 1.69 毫米（轴向）。系统总检测灵敏度为363.3kcps/微居里/ml。在我们乳腺成像和活检系统的持续发展中，我们建议进一步优化 PET 系统；解决我们最初的测试制度中发现的一些薄弱环节（例如计数率性能）。我们还建议在当前的 PEM-PET 系统中添加锥形束 X 射线计算机断层扫描 (CT) 扫描仪，从而创建 PEM-PET-CT 乳腺成像和活检设备。 PEM-PET-CT 将具有在数据采集过程中连续旋转的独特能力，从而能够快速生成 PET 和 CT 图像。通过集成 CT 成像仪获得的解剖信息将允许将乳房和异常区域的结构特征与这些区域的功能信息相关联。因此，这两种方法可以很好地互补。 CT 图像提供的数据还将用于改进对可能混淆放射性示踪剂浓度定量测量的物理现象的校正。最后，在人体试验中对这两个应用中的完整系统进行测试，将其性能与全身 PET、MRI 和 MRS 进行比较。这些研究的数据对于规划未来更大规模的人体试验至关重要。我们设想 PEM-PET-CT 可用于检测乳房致密且乳房 X 光检查不确定的女性病变，这些女性具有其他癌症风险因素。它还可以用作诊断作用，作为评估可疑病变或微钙化的“复查”方法。最后，该系统独特的定量能力可以促进其在化疗的治疗评估中的应用，特别是在小肿瘤中。因此，这种新的多模式系统的开发是改善乳房护理的许多重要临床方面的独特机会。公共健康相关性 本申请建议继续开发专用的乳腺 PET-CT 系统。该设备可有助于乳腺癌的检测、诊断和治疗评估。