ROLE OF GABA INPUTS FROM ZONA INCERTA TO CORTEX

GABA 从未断带到皮质输入的作用

• 批准号: 3415910
• 负责人: RICK C.S. LIN
• 金额: $ 14.73万
• 依托单位: ALLEGHENY UNIVERSITY OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-01-01 至 1993-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3415910
• 关键词: brain mapping; cerebral cortex; diencephalon; electron microscopy; electrophysiology; fluorescence microscopy; fluorescent dye /probe; gamma aminobutyrate; immunocytochemistry; laboratory rat; microelectrodes; nerve threshold; neural plasticity; neuroanatomy; neurogenesis; neurons; neurotransmitters; single cell analysis; spinal trigeminal nucleus; stereotaxic techniques; stimulus /response; superior colliculus

The long term objective of this proposal is to investigate the functional role of zona incerta on cortical function, plasticity and development. Previous studies have suggested that zona incerta is associated with a variety of complex functions including, pain, visual discrimination, ingestive behavior, sensory/motor control mechanisms, arousal and attention. Recently, we have demonstrated that neurons in zona incerta project directly to the whole cerebral cortex and this pathway is bilateral, roughly topographically organized and developed early in post-natal life. In addition, many of these incerto-cortical projecting neurons are GABAergic. This pathway has not been described previously and our current hypothesis is that zona incerta may be similar in functions as the monoaminergic and cholinergic systems. In the proposed studies, we will use neuroanatomical, immunohistochemical and electrophysiological approaches to investigate the physiological role of zona incerta on cortical development, plasticity and normal function. The main contribution of this proposal should provide new insights on cortical function and related diseases such as Alzheimer and Schizophrenia.

该提议的长期目标是调查 Zona Incerta在皮质功能，可塑性和 发展。 先前的研究表明Zona Incerta是 与各种复杂功能有关，包括疼痛，视觉 歧视，摄取行为，感觉/运动控制机制， 唤醒和关注。 最近，我们证明了神经元 Zona Incerta直接向整个大脑皮层项目 途径是双边的，大致在地形上组织和发展 在产后生活的早期。 此外，其中许多不属于皮层 投射神经元是GABA能。 该途径尚未描述 以前，我们目前的假设是Zona Incerta可能是 功能与单胺能和胆碱能系统相似。 在 拟议的研究，我们将使用神经解剖学，免疫组织化学 和电生理方法研究生理学 Zona Incerta在皮质发育，可塑性和正常状态下的作用 功能。 该提案的主要贡献应提供新的 关于皮质功能和相关疾病的见解，例如阿尔茨海默氏症和 精神分裂症。