CHINESE TEA AND STOMACH CANCER IN SHANGHAI

上海的中国茶与胃癌

• 批准号: 3423317
• 负责人: CHUNG-CHENG HSIEH
• 金额: $ 1.65万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1994-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3423317
• 关键词: China; cancer risk; carcinogenesis inhibitor; chemoprevention; food processing /preparation; human subject; interview; neoplasm /cancer epidemiology; nutrition aspect of cancer; nutrition related tag; questionnaires; stomach neoplasms; tea; vegetables

A population-based case-control study is proposed to study the effect of Chinese green tea on risk of stomach cancer. Based on findings from recent experimental and epidemiologic studies it is hypothesized that the consumption of green tea decreases the risk of stomach cancer and the effect is stronger than that of the consumption of black tea. In light of recent findings on the beneficial effect of garlic and allium vegetables on stomach cancer risk, the study also proposes to examine whether these vegetables consumed raw, semi-cooked, or fully-cooked form would confer the same degree of protection. The study will be conducted at Hongko district and Nanhui county, two areas of Shanghai, China. All the incidence cases of primary stomach cancer occurring over a two-year period are eligible. The community controls will be one-for-one matched to the cases on sex, age, and area of residence. With the high incidence rate in this study population, 800 cases and 800 controls are expected to be enrolled. Home interview will be conducted to obtain information on type and frequency of tea consumption, type and quantity of allium vegetables consumed separately in raw, slightly cooked, or fully-cooked categories, dietary intake in four different time periods corresponding to historical events in China, education and occupation, tobacco and alcohol use, past medical history and family medical history. Standard analytic methods for matched case-control studies will be performed. Stomach cancer is prevalent in many parts of the world. If green tea is found to protective, it would add to the limited list of agents which have anticarcinogenic effect. Information on the mode of allium vegetables intake and the stomach cancer risk will be relevant for prevention application.

提出了一项基于人群的病例对照研究来研究 中国绿茶患有胃癌的风险。 根据最近的发现 实验和流行病学研究可以假设 绿茶的消费降低了胃癌的风险和 效果比消耗红茶的效果要强。 鉴于 关于大蒜和葱蔬菜对有益作用的最新发现 胃癌的风险，该研究还建议检查是否 蔬菜食用原始，半煮熟或完全煮熟的形式将赋予 相同的保护程度。 该研究将在洪科区进行 Nanhui县，中国上海两个地区。 所有发生案例 在两年内发生的原发性胃癌符合条件。 社区控制措施将与性别案件相匹配， 年龄和居住区。 在这项研究中的发病率很高 预计将招募人口，800例和800例对照。 家 将进行访谈以获取有关类型和频率的信息 分别消费的葱蔬菜的茶消费，类型和数量 在原始，熟悉或完全煮熟的类别中，饮食摄入量四个 与中国历史事件相对应的不同时间段， 教育和职业，烟草和饮酒，过去的病史以及 家庭病史。 匹配的病例对照的标准分析方法 将进行研究。 胃癌在许多地方普遍存在 世界。 如果发现绿茶具有保护性，它将增加 有限的具有抗癌作用的药物清单。 信息 葱属蔬菜摄入和胃癌风险的模式是 与预防申请有关。