PrEP Implementation Science with Hard to Reach Populations in India

印度难以接触人群的 PrEP 实施科学

• 批准号: 10369556
• 负责人: Anne Elizabeth Fehrenbacher
• 金额: $ 18.22万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10369556
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Adherence; Adopted; Adoption; Applications Grants; Australia; COVID-19; California; Caring; Continuity of Patient Care; Country; Data; Discrimination; Doctor of Philosophy; Eastern Africa; Effectiveness; Epidemic; Epidemiologist; Evaluation; Evidence based practice; Faculty; Family; Female; Funding; Goals; HIV; Health; Healthcare; Incidence; India; Intervention; Interview; Left; Los Angeles; Mentors; Methodology; Methods; Modeling; Monitor; NIH Office of AIDS Research; Nigeria; Occupations; Oral; Patients; Persons; Pilot Projects; Policies; Population; Prevalence; Provider; Psychiatry; Randomized Controlled Trials; Records; Reporting; Research; Research Institute; Research Personnel; Research Priority; Research Training; Risk; Rural; Safety; Science; Self Management; Sexual and Gender Minorities; Site; South Africa; Southern Africa; Stigmatization; Strategic Planning; Testing; Training; United States; United States National Institutes of Health; Universities; Vertebral column; Violence; Work; barrier to care; base; biobehavior; care systems; career; chronic care model; concept mapping; design; digital; eHealth; efficacy evaluation; evidence base; experience; experimental study; female sex worker; follow-up; gender minority group; gender minority health; global health; health disparity; implementation evaluation; implementation framework; implementation outcomes; implementation process; implementation science; implementation tool; innovation; male; mobile computing; novel; organizational readiness; outreach clinics; pilot test; pre-exposure prophylaxis; preference; prevention service; prototype; public health research; research and development; scale up; self testing; sex; skills; social; social exclusion; staff intervention; stressor; success; tool; transgender; uptake

PROJECT SUMMARY/ABSTRACT Anne E. Fehrenbacher, PhD, MPH is a social epidemiologist in the Department of Psychiatry and Biobehavioral Sciences at the University of California, Los Angeles and a Fogary GloCal Fellow at the Public Health Research Institute of India. Dr. Fehrenbacher’s long-term career goal is to become an independent investigator with expertise in implementation science for HIV interventions with stigmatized populations. The proposed K01 research and training plan will provide Dr. Fehrenbacher with the methodological and practical skills to meet this goal. The present study will evaluate the acceptability, feasibility, and sustainability of an adapted WHO E-PrEP Implementation Tool to increase PrEP uptake, retention, and adherence. Dr. Fehrenbacher’s research plan will address three specific aims guided by the EPIS Framework of Implementation Science: 1) to model barriers and facilitators at the policy, structural, and organizational levels for adopting the WHO E-PrEP Implementation Tool to support PrEP rollout in targeted interventions in India; 2) to assess patient and provider preferences for bundled intervention components to inform the adaptation, localization, and tailoring of the WHO E-PrEP Implementation Tool; and 3) to evaluate the acceptability, feasibility, and sustainability of the adapted WHO E-PrEP Implementation Tool. The first aim will be addressed through concept mapping and bottleneck analysis with policymakers, health officials, and targeted intervention staff to visualize stakeholder priorities for PrEP implementation. The second aim will be addressed using conjoint analysis experiments conducted with patients and providers assessing bundled intervention attributes to elucidate the relative importance of each attribute on the likelihood of successful implementation. The third aim will involve a pilot cluster randomized controlled trial to evaluate implementation processes and outcomes along the HIV prevention continuum for testing, linkage, PrEP uptake, retention, and adherence. Dr. Fehrenbacher’s training objectives correspond with each of these specific aims, as follows: 1) to gain expertise in implementation science methods; 2) to gain expertise in the design and adaptation of eHealth interventions; and 3) to gain expertise in monitoring and evaluation of longitudinal interventions. The findings from this implementation science study will aid in the scale-up of sustainable biobehavioral interventions to reduce HIV disparities among stigmatized groups across India.

项目概要/摘要 Anne E. Fehrenbacher，博士，公共卫生硕士，精神病学系社会流行病学家， 加州大学洛杉矶分校生物行为科学系和公共研究中心 Fogary GloCal 研究员 印度健康研究所。Fehrenbacher 博士的长期职业目标是成为一名独立人士。 具有对受侮辱人群实施艾滋病毒干预的科学专业知识的调查员。 拟议的 K01 研究和培训计划将为 Fehrenbacher 博士提供方法论和实践 本研究将评估实现这一目标的可接受性、可行性和可持续性。 调整了世卫组织 E-PrEP 实施工具，以提高 PrEP 的吸收、保留和依从性。 Fehrenbacher 博士的研究计划将解决由 EPIS 框架指导的三个具体目标 实施科学：1）在政策、结构和组织层面对障碍和促进因素进行建模 采用世卫组织 E-PrEP 实施工具来支持在印度开展有针对性的 PrEP 2)； 评估患者和提供者对捆绑干预组件的偏好，以告知适应情况， 世卫组织 E-PrEP 实施工具的本地化和定制；以及 3) 评估可接受性； 改编后的 WHO E-PrEP 实施工具的可行性和可持续性 第一个目标将得到解决。 通过与政策制定者、卫生官员的概念图绘制和瓶颈分析以及有针对性的干预 工作人员将利益相关者实施 PrEP 的优先事项形象化，第二个目标将通过使用来实现。 与患者和提供者进行联合分析实验，评估捆绑干预属性 阐明每个属性对成功实施可能性的相对重要性。 目标将涉及试点集群随机对照试验，以评估实施过程和结果 沿着 HIV 预防连续体进行检测、关联、PrE​​P 的吸收、保留和依从性。 Fehrenbacher 博士的培训目标与这些具体目标相对应，如下：1) 2) 获得电子医疗设计和适应方面的专业知识 干预措施；3) 获得监测和评估纵向干预措施的专业知识。 从这项实施科学研究将有助于扩大可持续生物行为干预措施 减少印度各地受污名群体之间的艾滋病毒差异。