SYMPOSIUM ON 02-BINDING HEME

02-结合血红素研讨会

• 批准号: 3435641
• 负责人: GERD N LA MAR
• 金额: $ 1万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1989-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3435641
• 关键词: binding proteins; biochemistry; biophysics; chemical structure function; gene expression; genetics; hemoglobin; hormone regulation /control mechanism; meeting /conference /symposium; molecular biology; mutagens; myoglobin; oxygen; physiology

Support is requested for a Symposium to convene on 9-13 October, 1988, at the Asilomar Conference Grounds, Pacific Grove, California, for the purposes of assessing the state of our understanding of the structure, dynamics, function, and genetics of the oxygen binding heme proteins, myoglobin and hemoglobin. The conference seeks to bring together approximately 140 leading scientists and young investigators to hear about recent advances in protein dynamics, structural methodology, and, in particular, site-directed mutagenesis, as they affect our understanding of the phenomenon of oxygen binding. The relationship of the properties of modified Hb as they could serve as clinical agents will be discussed. This is the first heme protein meeting dealing in a major way with Hb and Mb genetics and its potential impact on heme protein research. Our goal is to develop both some strategies and for effectively using the new molecules, as well as expand future research directions. The participants will represent the most active workers on heme proteins from the diverse discipline of biochemistry biophysics, chemistry, genetics, molecular biology, and physiology, who generally meet together only in fragmented combinations in large, scheduled meetings. The symposium site was selected based on its ideal secluded, sylvan setting that will allow extensive discussion and personal interaction in a completely self-contained setting providing food and lodging, as well as the conference hall.

要求在10月9日至13日召集研讨会。 1988年，在太平洋格罗夫（Pacific Grove）的Asilomar会议场上 为了评估我们的状态，加利福尼亚 了解结构，动力学，功能和遗传学 氧结合血红素蛋白，肌红蛋白和血红蛋白。 会议试图将大约140个领导 科学家和年轻的调查人员了解最近进步 在蛋白质动力学，结构方法论，尤其是 定向诱变，因为它们会影响我们对 氧结合的现象。 属性的关系 修改的HB可以用作临床代理的HB 讨论。 这是第一次交易的血红素蛋白会议 HB和MB遗传学及其对潜在影响的主要方式 血红素蛋白研究。 我们的目标是发展两者 策略，有效地使用新分子以及 扩展未来的研究方向。 参与者将代表 来自多元化的血红素蛋白质最活跃的工人 生物化学生物物理学的学科，化学，遗传学， 分子生物学和生理学，他们通常在一起 仅在大型计划的会议上进行分散的组合。 根据其理想的僻静选择，选择了研讨会场所 Sylvan设置将允许广泛讨论和个人 在完全独立的环境中提供食物的互动 和住宿以及会议厅。