DEVELOPMENTAL PRECURSORS OF SCHIZOPHRENIA

精神分裂症的发育前兆

• 批准号: 3428882
• 负责人: ELAINE Fran WALKER
• 金额: $ 3.66万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3428882
• 关键词: adult human (21+); attention; behavior test; child behavior disorders; cinematography; communication behavior; disease /disorder proneness /risk; emotions; human subject; interview; longitudinal human study; preschool child (1-5); psychomotor function; schizophrenia; social behavior

The present research is concerned with the developmental precursors of schizophrenia. It utilizes a novel methodology that will facilitate the study of premorbid factors at a detailed level of analysis that has not been possible with previous approaches. Childhood home movies and developmental information will serve as the data base for the study of early behavioral phenomena in individuals diagnosed as suffering from schizophrenia in adulthood. There will be three comparison groups: Healthy siblings of patients, patients suffering from affective disorders, and subjects from families with no mental illness. The first phase of this research program will use the home movies to study molar behavioral characteristics of the subjects at 1 to 2 years of age and to develop rating scales for examining the molecular aspects of neuromotor, attentional and socioemotional functions. Based upon past findings and current theoretical models, it is predicted that constitutional vulnerability to schizophrenia will be manifested in infancy on the molar behavioral level as well as in specific functional domains. On the molar level, it is predicted that preschizophrenic children will show decreased levels of communicative and motor behavior when compared to control subjects. The methodology of the present study holds promise for addressing many other questions that are of critical relevance to our understanding of the etiology of schizophrenia. The rating scales devised in the first phase of the research program will be used in subsequent work to examine the development of neuromotor, attentional and socioemotional functions. This will permit molecular analyses of these functional domains across childhood and will provide data for determining: 1) the earliest period at which deviations are apparent in the developmental trajectory of schizophrenia, 2) the extent to which the development of schizophrenic and affective patients is distinguishable, 3) the sequence of emergence of developmental deviations in the three domains, and 4) the relation between early developmental factors and the later clinical course of the disorder.

本研究与发展有关 精神分裂症的前体。 它利用一种新颖的方法 将促进在详细水平上研究前虫的因素 以前的方法是不可能的。 童年家庭电影和发展信息将服务 作为研究早期行为现象的数据库 被诊断为患有精神分裂症的人 成年。 将有三个比较组：健康 患者的兄弟姐妹，患有情感障碍的患者， 以及没有精神疾病的家庭的受试者。 第一阶段 该研究计划将使用家庭电影来学习磨牙 1至2岁时受试者的行为特征 并开发用于检查分子方面的评分量表 神经运动，注意力和社会情感功能。 基于 通过过去的发现和当前的理论模型，可以预测 对精神分裂症的宪法脆弱性将是 在摩尔行为水平以及在 特定的功能域。 在摩尔水平上，可以预测 chiz夫儿童将显示出降低的水平 与对照相比，交流和运动行为 主题。 本研究的方法有望 解决与与 我们对精神分裂症病因的理解。 评分 在研究计划的第一阶段设计的量表将是 在随后的工作中用于检查的发展 神经运动，注意力和社会情感功能。 这会 允许对这些功能域的分子分析 童年，将提供确定的数据：1）最早 发育中明显偏差的时期 精神分裂症的轨迹，2） 精神分裂症和情感患者的发展是 可区分，3）发育的出现顺序 这三个域中的偏差，以及4）早期之间的关系 发展因素和后来的临床过程 紊乱。