VITAMIN D DEFICIENCY AND PROSTATE CARCINOMA

维生素 D 缺乏症和前列腺癌

基本信息

批准号：
3423130
负责人：
GARY G SCHWARTZ
金额：
$ 3.46万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-08-01 至 1991-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3423130
关键词：
1,25 dihydroxycholecalciferol 25 hydroxycholecalciferol African African American DNA binding protein binding proteins cancer risk carcinogenesis inhibitor carcinoma human subject neoplasm /cancer epidemiology nutrition aspect of cancer nutrition related tag prostate neoplasms vitamin D deficiency vitamin biosynthesis vitamin metabolism

项目摘要

Prostate cancer is the second largest cause of cancer mortality among males in the United States (U.S.). Despite the importance of this cancer, little is known about its etiology. The proposed study investigates the hypothesis that Vitamin D deficiency may be a risk factor for prostate carcinoma. This hypothesis is based on the observation that the geographic distribution of prostate cancer parallels closely the availability of ultraviolet radiation, the principle determinant of Vitamin D levels. The higher prostate cancer rates observed among Blacks versus Whites in the U.S., and between U.S. Blacks versus African Blacks, are also interpretable on the basis of Vitamin D deficiency. The hypothesis is consistent with recent experimental data which indicate that Vitamin D inhibits the expression of cellular oncogenes that are amplified in human prostate cancer cells. The hypothesis will be tested in a case-control study of 50 patients with prostate carcinoma and 50 patients with benign prostatic hypertrophy as controls. Cases and controls will be compared with respect to their serum concentrations of Vitamin D metabolites and the allelic distribution of D-Binding Protein. Differences in skin pigmentation and solar exposure habits will also be measured and compared.

前列腺癌是癌症死亡率的第二大原因在美国的男性中（美国）。尽管很重要在这种癌症中，对其病因知之甚少。提议研究调查了维生素D缺乏症的假设可能成为前列腺癌的危险因素。该假设是基于关于前列腺的地理分布的观察癌症与紫外线辐射的可用性紧密相似，维生素D水平的主要决定因素。更高在黑人与白人之间观察到的前列腺癌率美国以及美国黑人与非洲黑人之间的可以根据维生素D缺乏来解释。这假设与最近的实验数据一致表明维生素D抑制细胞的表达在人前列腺癌细胞中扩增的癌基因。这假设将在50例患者的病例对照研究中进行检验前列腺癌和50例良性前列腺患者肥大作为对照。将比较案例和对照关于其血清浓度的维生素D 代谢物和D结合蛋白的等位基因分布。皮肤色素沉着和太阳接触习惯的差异将也可以测量和比较。