NEUROPHYSIOLOGY AND DEVELOPMENT IN AUTISM AND DYSPHASIA

自闭症和失语症的神经生理学和发育

• 批准号: 3412867
• 负责人: Alan J Lincoln
• 金额: $ 9.05万
• 依托单位: CHILDREN'S HOSPITAL AND HEALTH CENTER
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-05-01 至 1991-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3412867
• 关键词: autism; child (0-11); child behavior; child mental disorders; electroencephalography; electrophysiology; human subject; neurophysiology; neuropsychology; speech disorders

This proposed investigation will compare the neurophysiology of children (ages 8-12) and older adolescents and adults (ages > 14 years) who are characterized as having an early disorder of development. ERPs will be used to evaluate the brain-behavior relationships in people with autism, receptive developmental dysphasia, and their matched normal controls. We have already found evidence of differences in the physiology as measured by the ERP in adolescents and adults with autism and dysphasia. However, we do not know how this pathophysiology is expressed in younger autistic and dysphasic children and whether or not the differences we have found interact with the large developmental changes in electrophysiology and behavior that occur in normal children. The proposed experiments will examine both sensory and cognitive event related potentials in both auditory and visual paradigms. Our results will let us evaluate each of the several differences in components of the ERP which we already discovered between the clinical groups and normal controls. Specifically, we will examine P2, P3b, A/Pcz/300, and Nc in experiments designed to manipulate the sensory, attentional, and orientating mechanisms that may be abnormal in autism and dysphasia.

该提出的研究将比较 儿童（8-12岁）和年长的青少年和成年人（年龄> 14岁） 年），被描述为早期疾病 发展。 ERP将用于评估脑行为 自闭症患者的关系，接受性发展 焦点及其匹配的正常对照。 我们已经 找到了由生理学差异的证据 ERP患有自闭症和不适性的青少年和成年人。 然而， 我们不知道这种病理生理学是如何在年轻的 自闭症和痴呆症儿童以及差异是否 我们发现与大型发展变化相互作用 正常儿童发生的电生理学和行为。 这 建议的实验将检查感觉和认知事件 听觉和视觉范式中的相关电位。 我们的 结果将使我们评估各个几个差异 我们已经发现的ERP组件 临床组和正常对照。 具体来说，我们将检查 旨在操纵的实验中的P2，P3B，A/PCZ/300和NC 可能是感官，注意力和定向机制 自闭症和肿份异常。

项目成果

Auditory processing abilities in non-retarded adolescents and young adults with developmental receptive language disorder and autism.

患有发育性接受性语言障碍和自闭症的非弱智青少年和年轻人的听觉处理能力。

• DOI: 10.1016/0093-934x(92)90086-t
• 发表时间: 1992
• 期刊: Brain and language
• 影响因子: 2.5
• 作者: Lincoln,AJ;Dickstein,P;Courchesne,E;Elmasian,R;Tallal,P
• 通讯作者: Tallal,P