Effects of Sleep Modification on Smoking Cessations and Cardiovascular Health

睡眠改变对戒烟和心血管健康的影响

• 批准号: 9432534
• 负责人: Freda Patterson
• 金额: $ 30.06万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9432534
• 关键词: Adult; Aerobic; Aerobic Exercise; Age; American; Blinded; Blood Pressure; Cardiac rehabilitation; Cardiovascular Diseases; Cardiovascular system; Centers of Research Excellence; Chronic; Communities; Comorbidity; Data; Experimental Designs; Goals; Health; Independent Living; Individual; Interval training; Intervention; Intervention Studies; Link; Measures; Mediating; Modification; Outcome; Oxygen Consumption; Persons; Physical activity; Population; Program Reviews; Protocols documentation; Quality of life; Randomized; Recommendation; Research; Rest; Safety; Sleep; Stimulus; Stroke; Testing; Time; Training; Training Programs; Walking; acute stroke; aging population; arm; brachial artery; cardiovascular fitness; cardiovascular health; chronic stroke; comparative efficacy; cost; disability; exercise intensity; exercise training; high risk; improved; intervention effect; novel; post stroke; primary outcome; programs; secondary outcome; sedentary; smoking cessation; stroke incidence; stroke survivor; success; therapy design; treadmill training; walking speed

PROJECT SUMMARY/ABSTRACT The overarching goal of this research is to develop interventions that improve the overall health and quality of life of individuals post-stroke. It is estimated that 75% of all stroke survivors have comorbid cardiovascular conditions and significantly limited cardiovascular capacity. Many studies have shown that cardiovascular fitness after stroke is not commensurate with independent function and is a major contributor to post-stroke disability. The onset of disability makes it difficult for stroke survivors to engage in physical activity, causing them to remain sedentary and extremely inactive and thus a vicious cycle of disability�inactivity�poor cardiovascular fitness ensues. Even after intervention, most stroke survivors VO2peak levels remain below the suggested minimum required for independent living. It is therefore necessary to test new interventions that result in greater improvements in cardiovascular fitness and health and walking function after stroke. Among individuals with cardiovascular disease, recent studies have found a high intensity interval training program (HIIT) to be as safe and a more effective stimulus for improving cardiovascular fitness and health compared to traditional aerobic training programs. The efficacy of a HIIT program has not been tested in persons with chronic stroke, but given the success in other populations, it is a promising intervention to investigate in this group. Therefore, the primary aim of this proposal is to test whether a HIIT program results in greater improvements in cardiovascular health and fitness compared to a standard aerobic training program in those with chronic stroke. The secondary aims are to: a) test whether a HIIT program can result in greater improvements in walking function and activity than a standard aerobic training program and b) test whether improvements in cardiovascular fitness and real-world physical activity are linked. Using a randomized controlled experimental design, 53 chronic (> 6 months) stroke survivors, will receive either 12 weeks of a HIIT program or 12 weeks of a standard aerobic treadmill training program. The primary and secondary outcomes of cardiovascular health and fitness and walking activity will be assessed by blinded evaluators prior to initiating treatment (baseline) and immediately after the last treatment (12 weeks post baseline). The expected positive effects of this novel intervention will provide rationale for recommendations for exercise training in chronic stroke and data for larger studies combining aerobic training with interventions designed to improve real-world daily physical activity after stroke.

项目概要/摘要 这项研究的总体目标是开发改善整体健康和质量的干预措施 据估计，75% 的中风幸存者患有心血管疾病。 许多研究表明，心血管能力明显受到限制。 中风后的健康与独立功能不相称，是中风后的主要原因 残疾的发生使中风幸存者难以进行体力活动，从而导致 他们保持久坐和极度不活动，从而形成残疾、不活动的恶性循环 即使在干预后，大多数中风幸存者的摄氧量峰值水平仍低于正常水平。 因此，有必要测试新的干预措施： 导致中风后心血管健康和步行功能的更大改善。 患有心血管疾病的人，最近的研究发现高强度间歇训练计划 与 传统的有氧训练计划的效果尚未在患有此病的人身上进行过测试。 慢性中风，但鉴于在其他人群中取得的成功，这是一种有前途的干预措施 因此，该提案的主要目的是测试 HIIT 计划是否能带来更大的效果。 与标准有氧训练计划相比，心血管健康和健身方面的改善 次要目标是：a) 测试 HIIT 计划是否可以带来更大的效果。 与标准有氧训练计划相比，步行功能和活动有所改善，b) 测试是否 心血管健康的改善和现实世界的身体活动是相关的。 对照实验设计，53 名慢性（> 6 个月）中风幸存者将接受 12 周的 HIIT 计划或 12 周的标准有氧跑步机训练计划的主要和次要结果。 心血管健康和健身以及步行活动的评估将在开始之前由盲法评估员进行评估 开始治疗（基线）和最后一次治疗后（基线后 12 周）。 这种新颖干预措施的积极效果将为运动训练的建议提供依据 慢性中风和更大型研究的数据，将有氧训练与旨在改善的干预措施相结合 中风后现实世界的日常身体活动。