PROSPECTIVE STUDY OF COGNITIVE FUNCTION IN WOMEN

女性认知功能的前瞻性研究

• 批准号: 2442317
• 负责人: FRANCINE GRODSTEIN
• 金额: $ 11.42万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2442317
• 关键词: aging; alleles; antioxidants; apolipoproteins; clinical research; cognition; dementia; dietary supplements; epidemiology; estrogens; female; gene environment interaction; health behavior; hormone therapy; human genetic material tag; human middle age (35-64); human old age (65+); human subject; lifestyle; longitudinal human study; neuropsychological tests; nurses; postmenopause; tocopherols

DESCRIPTION: (Adapted from the Applicant's Abstract): In the U.S. 5% of women over age 60, 12% of those over age 75%, and as many as 28% of women past 85 years of age may be demented. The proposed study capitalized on the availability of a large and powerful epidemiologic dataset to advance the knowledge of potential risk factors for cognitive impairment. We propose to examine prospectively how estrogen use, dietary antioxidants especially vitamin E supplements, and genetic factors influence the development of cognitive decline in a group of women who are free of major illness at baseline. The interactions between environmental exposures and genetic factors will also be explored. The investigation investigation will be conducted within the Nurse's Health Study, a prospective cohort study begun in 1976 with 121,700 women. Extensive data have been accumulated from the women regarding lifestyle exposures and disease outcomes via biennial mail questionnaires. Information on hormone use includes currency of use, duration, dose, and type. For vitamin E, the currency of use and dosage have been reported since 1980. In 1989 blood samples were collected from 33,000 of the women; to accommodate the proposed analyses, all study subjects will be chosen from those who provided blood samples. We will conduct repeated tests of cognitive function by telephone to a group of 4,500 women aged 73-78 using a well-established and validated instrument. Baseline data from this testing will serve as the initiation of a prospective study of predictors of cognitive decline. Second interviews will be given to the same woman after a 2 year interval and in a sample a third test will be given at 4 years. A pilot study of the cognitive function test in approximately 500 Nurse's Health Study participants was highly successful; the participation rate was 92% and 10% of the subjects had scores which indicated cognitive dysfunction. Dementia is an increasingly important cause of death and disability, yet very little is known about ways to preserve cognitive function. Most prior investigations have been cross-sectional and smaller than the proposed study. In addition, while genetic aspects of dementia are increasingly being appreciated, virtually no studies have explored interactions between environmental and genetic factors. The Nurse's Health Study provides a highly cost efficient setting to investigate several lifestyle modification as well as genetic influences, which may be instrumental in preventing or delaying decline in cognitive function.

描述：（改编自申请人的摘要）：在美国5％ 60岁以上的妇女，年龄超过75％的妇女，多达28％的妇女 过去的85岁可能会痴呆。 拟议的研究大写了 可用的大型且强大的流行病学数据集以促进 了解认知障碍的潜在危险因素。 我们建议 前瞻性地检查雌激素的使用，尤其是饮食抗氧化剂如何 维生素E补充剂，遗传因素影响 一群没有重大疾病的妇女的认知能力下降 基线。 环境暴露与遗传之间的相互作用 还将探讨因素。 调查调查将是 在护士健康研究中进行的一项前瞻性队列研究开始 1976年有121,700名妇女。 大量数据已从 妇女关于生活方式的暴露和疾病结局，通过双年展 问卷。 有关激素使用的信息包括使用货币， 持续时间，剂量和类型。 对于维生素E，使用和剂量的货币 自1980年以来已有报道。1989年，从 33,000名妇女；为了适应拟议的分析，所有研究 将从提供血液样本的人中选择受试者。 我们将 通过电话对一组进行认知功能的重复测试 4,500名73-78岁的妇女使用建立良好且经过验证的工具。 该测试的基线数据将作为启动 对认知能力下降的预测指标的前瞻性研究。 第二次访谈 在2年间隔后，在样本A中将给同一妇女 第三个测试将在4年内进行。 认知的试点研究 大约500名护士健康研究参与者的功能测试是 非常成功；参与率为92％和10％的受试者 表明认知功能障碍的分数。 痴呆症是一个 越来越重要的死亡和残疾原因，但很少有 知道保留认知功能的方法。 大多数先前的调查 已经是横断面的，并且比拟议的研究小。 此外， 虽然痴呆症的遗传方面越来越受到赞赏，但 几乎没有研究探讨了环境与环境之间的互动 遗传因素。 护士的健康研究提供了高度成本效率的 设置调查几种生活方式修改以及遗传 影响，这可能有助于防止或延迟下降 认知功能。