PREVALENCE OF SLEEP APNEA IN AN AGED POPULATION

老年人中睡眠呼吸暂停的患病率

• 批准号: 3114504
• 负责人: Sonia Ancoli-Israel
• 金额: $ 12.27万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-04-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3114504
• 关键词: apnea; case history; health surveys; human morbidity; human mortality; human old age (65+); human subject; interview; longitudinal human study; patient monitoring device; prognosis; sign /symptom; sleep disorders

Sleep apnea is a serious disorder characterized by complete cessations of respiration during sleep. Current work indicated that 35% of VA inpatients >60 years old have more that 5 apneas per hour of sleep and 13% have over 20 apneas per hour of sleep. Little is known about the natural history, clinical implications, or risks of such wide-spread apnea. The first goal of this study is to describe the natural history and progression of sleep apnea and periodic leg movements in sleep (PLMS, a disorder of leg kicks during the night). Seventy-five elderly VA patients, already recorded between 1987-1989, and 37 independently-living elderly who have been previously recorded, will be rerecorded every two years for a four-year period. Each person will be recorded with a modified Medilog/Respitrace portable recorder and with oximetry for two nights. In addition, sleep symptoms and medical history will be followed. Clinically, we need to know how commonly a patient who was found to have significant sleep apnea continues to have apnea and related morbidity. The second goal is to examine the relationships between sleep apnea and mortality by following 700 elderly subjects who have been prospectively recorded in three studies. These subjects' survival will be followed to see if apnea predicts increased mortality.

睡眠呼吸暂停是一种严重的疾病，其特征是完全停止 睡眠期间的呼吸。 当前的工作表明35％的VA住院患者 > 60岁的年龄超过每小时睡眠5个呼吸暂停和13％的apneas 每小时睡眠20个呼吸暂停。 对自然历史知之甚少， 临床意义或如此广泛的呼吸暂停的风险。 第一个目标 这项研究是描述睡眠的自然历史和进展 睡眠中的呼吸暂停和周期性的腿部运动（PLMS，腿部障碍 晚上）。 已记录的75名老年VA患者 在1987年至1989年和37位独立生活的老年人之间 先前记录的，将每两年重新记录四年 时期。 每个人将通过修改的Midilog/Respitrace记录 便携式录音机和血氧仪两晚。 另外，睡觉 症状和病史将遵循。 临床上，我们需要知道 被发现患有明显睡眠呼吸暂停的患者通常是多么普遍 继续具有呼吸暂停和相关的发病率。 第二个目标是 通过遵循检查睡眠呼吸暂停和死亡率之间的关系 700名在三项研究中被前瞻性记录的老年受试者。 这些受试者的生存将遵循呼吸暂停是否预测 死亡率增加。