SOCIAL STATUS AND PREFERENCE FOR ETHANOL

社会地位和对乙醇的偏好

• 批准号: 3112587
• 负责人: LARISSA A POHORECKY
• 金额: $ 10.45万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-02-01 至 1995-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3112587
• 关键词: aggression; alcoholic beverage consumption; anxiety; body temperature; choice; ethanol; gas chromatography; laboratory rat; neurochemistry; neuroendocrine system; physiologic stressor; preference; social behavior; social dominance; social group process; social status; stressor; telemetry

Ingestion of ethanol (ET) by man generally occurs within a social context and stresses associated with social status are believed to contribute to ingestion of alcohol. The proposed research will contribute important new data on the role of social factors in the control of ET ingestion as well as the role of various predisposing factors (innate level of aggression, innate sensitivity to ET and innate preference for ET). The work also addresses an issue presently unknown - how group housing and social status affect responsiveness to an acute dose of ET. Our long term goal is to determine the neurochemical/neuroendocrine correlates of ET ingestion of group housed rats. Our hypothesis is that social status affects the ingestion of and sensitivity to ET in group housed rats. Water and ET ingestion of group (3 males/colony) or singly housed rats will be monitored continuously. For this, computer interfaced drinkomerers and subcutaneously implanted subject identification microchips will be employed. Experiment I will examine the effect of social status on ET ingestion. Animals will be pretested for their basal preference for ET to determine how innate preference for ET affects subsequent preference for ET and how it relates to subsequently developed social status. There will be 4 groups: group housed/choice of water and ET; group housed/water only; individually housed/choice of water and ET; individually housed/water only. During a 3 week period of group housing, intakes of water and ET and social status will be monitored and animals will be tested for several behavioral correlates: anxiety (elevate plus maze), social interaction, aggression (resident/intruder test) and taste preference. In Experiment II the treatment and testing procedures will be the same as in Experiment I except that animals will be pretested for their level of aggression prior to group housing. Thus, this study will determine the relationship of innate aggression to subsequent development of social status and ET preference. Experiment III's aim is to examine the relationship between innate sensitivity to ET, the development of social status and voluntary ingestion of ET. It will consist of 2 colony (A, B)- and 2 individually (C, D)- housed groups. Animals will be implanted with telemeters to allow continuous monitoring of body temperature. Groups A and C will be used to assess sensitivity to ET and groups B and D to assess BEC produced by the treatment. Using body temperature, animals will be pretested for sensitivity to ET. After a 3 week period of group housing, group A will be treated with 0 (saline), 0.5, 1.0, and 2.0 g/kg using a completely balanced design, and their body temperature will be assessed over a 24 hour period. Animals in group B will be given 2.0 g/kg followed by tail blood sampling for the determination of BEC at 30, 60, 120,240 and 360 minutes.

人类摄入乙醇（ET）通常发生在社会环境中 据信与社会地位相关的压力有助于 摄入酒精。 拟议的研究将为重要的新作用 关于社会因素在控制ET摄入中的作用的数据 作为各种诱发因素的作用（先天侵略水平， 对ET的先天敏感性和对ET的先天偏好）。 也是工作 解决目前未知的问题 - 团体住房和社会地位如何 影响ET急性剂量的反应性。 我们的长期目标是 确定摄入的神经化学/神经内分泌相关性 小组容纳大鼠。 我们的假设是社会地位影响 摄入和对ET的敏感性在组饲养大鼠中。 Water和Et 将监测摄入组（男性/殖民地）或单身饲养大鼠的组（3个男性/殖民地） 连续。 为此，计算机接口的饮用物和 皮下植入的受试者鉴定微芯片将是 雇用。 实验我将研究社会地位对ET的影响 摄取。 将对动物的基础偏好对ET进行预测试 确定对ET的先天偏好如何影响随后对ET的偏好 以及它与随后发展的社会地位的关系。 将有 4组：居民/ET的选择；仅容纳/水； 单独容纳/选择水；仅分别容纳/水。 在3周的小组住房，水和ET和社会的摄入量中 状态将受到监控，并将测试几种行为 相关：焦虑（提升迷宫），社交互动，侵略性 （居民/入侵者测试）和品味偏好。 在实验II中 治疗和测试程序将与实验I相同，除非 在小组之前，将对动物的侵略水平进行测试 住房。 因此，这项研究将确定先天的关系 侵略社会地位和ET偏好的后续发展。 实验III的目的是检查先天的关系 对ET的敏感性，社会地位的发展和自愿摄入 ET。 它将由2个殖民地（a，b） - 和2个单独（c，d）组成 - 安置的团体。 动物将植入遥测器以允许 连续监测体温。 A和C组将用于 评估对ET和B组的敏感性，以评估由 治疗。 使用体温，将对动物进行预测试 对ET的敏感性。 经过3周的小组住房，A组将是 用0（盐水），0.5、1.0和2.0 g/kg治疗 设计及其体温将在24小时内评估。 B组中的动物将给予2.0 g/kg，然后进行尾血抽样 为了确定30、60、120,240和360分钟的BEC。