SOCIAL STATUS AND PREFERENCE FOR ETHANOL

社会地位和对乙醇的偏好

• 批准号: 3112587
• 负责人: LARISSA A POHORECKY
• 金额: $ 10.45万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-02-01 至 1995-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3112587
• 关键词: aggression; alcoholic beverage consumption; anxiety; body temperature; choice; ethanol; gas chromatography; laboratory rat; neurochemistry; neuroendocrine system; physiologic stressor; preference; social behavior; social dominance; social group process; social status; stressor; telemetry

Ingestion of ethanol (ET) by man generally occurs within a social context and stresses associated with social status are believed to contribute to ingestion of alcohol. The proposed research will contribute important new data on the role of social factors in the control of ET ingestion as well as the role of various predisposing factors (innate level of aggression, innate sensitivity to ET and innate preference for ET). The work also addresses an issue presently unknown - how group housing and social status affect responsiveness to an acute dose of ET. Our long term goal is to determine the neurochemical/neuroendocrine correlates of ET ingestion of group housed rats. Our hypothesis is that social status affects the ingestion of and sensitivity to ET in group housed rats. Water and ET ingestion of group (3 males/colony) or singly housed rats will be monitored continuously. For this, computer interfaced drinkomerers and subcutaneously implanted subject identification microchips will be employed. Experiment I will examine the effect of social status on ET ingestion. Animals will be pretested for their basal preference for ET to determine how innate preference for ET affects subsequent preference for ET and how it relates to subsequently developed social status. There will be 4 groups: group housed/choice of water and ET; group housed/water only; individually housed/choice of water and ET; individually housed/water only. During a 3 week period of group housing, intakes of water and ET and social status will be monitored and animals will be tested for several behavioral correlates: anxiety (elevate plus maze), social interaction, aggression (resident/intruder test) and taste preference. In Experiment II the treatment and testing procedures will be the same as in Experiment I except that animals will be pretested for their level of aggression prior to group housing. Thus, this study will determine the relationship of innate aggression to subsequent development of social status and ET preference. Experiment III's aim is to examine the relationship between innate sensitivity to ET, the development of social status and voluntary ingestion of ET. It will consist of 2 colony (A, B)- and 2 individually (C, D)- housed groups. Animals will be implanted with telemeters to allow continuous monitoring of body temperature. Groups A and C will be used to assess sensitivity to ET and groups B and D to assess BEC produced by the treatment. Using body temperature, animals will be pretested for sensitivity to ET. After a 3 week period of group housing, group A will be treated with 0 (saline), 0.5, 1.0, and 2.0 g/kg using a completely balanced design, and their body temperature will be assessed over a 24 hour period. Animals in group B will be given 2.0 g/kg followed by tail blood sampling for the determination of BEC at 30, 60, 120,240 and 360 minutes.

人类摄入乙醇 (ET) 通常发生在社会环境中 人们认为与社会地位相关的压力会导致 摄入酒精。 拟议的研究将贡献重要的新成果 关于社会因素在控制 ET 摄入中的作用的数据 作为各种诱发因素的作用（先天的攻击性水平， 对 ET 的先天敏感性和对 ET 的先天偏好）。 作品还 解决了一个目前未知的问题——群体住房和社会地位如何 影响对急性剂量 ET 的反应。 我们的长期目标是 确定 ET 摄入的神经化学/神经内分泌相关性 组饲养老鼠。 我们的假设是社会地位影响 组内大鼠对 ET 的摄入和敏感性。 水和ET 将监测群体（3只雄性/群体）或单养大鼠的摄入情况 连续地。 为此，计算机连接了饮酒者和 皮下植入受试者识别微芯片将 受雇。 实验一将检验社会地位对 ET 的影响 摄入。 将预先测试动物对 ET 的基本偏好 确定对 ET 的先天偏好如何影响后续对 ET 的偏好 以及它与随后发展的社会地位有何关系。 将有 4组：集体饲养/选择水和ET；集体居住/仅供水； 单独饲养/选择水和ET；单独安置/仅水。 在 3 周的集体住宿期间，水和 ET 的摄入量以及社交活动 将监测动物的状态并对动物进行多种行为测试 相关因素：焦虑（提升加迷宫）、社交互动、攻击性 （居民/入侵者测试）和口味偏好。 在实验二中 处理和测试程序将与实验 I 中相同，除了 在分组之前将预先测试动物的攻击性程度 住房。 因此，这项研究将确定先天的关系 攻击性会影响随后的社会地位和外星人偏好的发展。 实验三的目的是检验先天与先天之间的关系 对 ET 的敏感性、社会地位的发展和自愿摄入 ET。 它将由 2 个菌落 (A、B)- 和 2 个单独的菌落 (C、D)- 组成 安置团体。 动物将被植入遥测仪，以允许 持续监测体温。 A 组和 C 组将用于 评估对 ET 和 B 组和 D 组的敏感性，以评估 ET 产生的 BEC 治疗。 使用体温，对动物进行预测试 对 ET 的敏感性。 经过 3 周的集体住宿后，A 组将 使用完全平衡的 0（盐水）、0.5、1.0 和 2.0 g/kg 进行处理 设计，并将在 24 小时内评估他们的体温。 B组动物给予2.0g/kg，随后尾部采血 用于测定 30、60、120,240 和 360 分钟的 BEC。