Racial/Ethnic Disparities in ADRD Risk: The Impact of Social Relations

ADRD 风险中的种族/民族差异：社会关系的影响

基本信息

批准号：
10866199
负责人：
TONI Claudette ANTONUCCI
金额：
$ 34.52万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10866199
关键词：
Adult Age Alzheimer&apos s Disease Pathway Alzheimer&apos s disease related dementia American Apolipoprotein E Arabs Area Black Populations Buffers Characteristics Cognition Cognitive Data Data Collection Dimensions Disparity Economics Elderly Electronic Mail Ethnic Origin Ethnic Population Genes Genetic Genotype Health Incidence Influentials Intervention Learning Life Cycle Stages Link Longevity Longitudinal Studies Longitudinal cohort study Measures Modeling Modification Pattern Race Resources Risk Risk Factors Sampling Socioeconomic Factors Spouses Stress Structure Testing aged behavior measurement cohort comparison group cost effective critical period dementia risk design disparity reduction ethnic disparity ethnic minority population experience innovation member metropolitan middle age novel protective factors racial disparity racial minority population racial population recruit social social interventions theories trend

项目摘要

Growing evidence suggests that certain racial/ethnic minority groups experience the highest incidence of Alzheimer’s disease and related dementias (ADRD) risk in the US. Longitudinal studies with diverse samples that collect social and behavioral measures in early and midlife hold exceptional promise for identifying modifiable protective factors for cognitive health and life course pathways of ADRD risk. Social relations, a multidimensional concept with high intervention potential, have been found to predict cognitive health and ADRD, though these associations may differ across race/ethnicity. Still not identified are: (1) how early and mid-life social relations are associated with ADRD risk in different racial/ethnic groups; and (2) specific aspects of social relations that modify ADRD risk. Characterizing how social relations vary as a function of race/ethnicity and clarifying unique links to ADRD risk will advance the field in terms of theory and intervention. This study will leverage three waves of the Social Relations Study plus a fourth wave of the >65 sample (currently in the field: N=330) to examine social relations and ADRD risk across racial/ethnic groups. We will collect a fourth wave of panel data aged <65 (N=244) and a new, representative Detroit metropolitan area sample (N=3400), using the original design, adding Arab Americans to parallel data collection now in the field. Specific aims are: Aim 1: Examine secular trends in social relations and health by race/ethnicity in two adult lifespan regionally representative cohorts. Aim 2: Identify aspects of social relations that have the greatest effects on ADRD risk among blacks, whites and Arab Americans in mid- and late- life. Aim 3: Identify longitudinal associations between social relations across the life course and ADRD risk among blacks and whites. We capitalize on an existing longitudinal cohort study of detailed social relations over ~30 years in a diverse lifespan sample (i.e., from age 8 to 93 in Wave 1). Adding cognitive and genetic measures, as well as extending racial/ethnic group comparisons to include Arab Americans in a new regionally representative sample (age 35+) provides a novel opportunity to study modifiable factors in midlife for ADRD risk. Findings will provide key information to develop strategies using the influential resource of social relations to reduce disparities. Further, the proposed study sets the stage for a newly representative longitudinal study of racial/ethnic disparities in ADRD risk.

越来越多的证据表明，某些种族/族裔少数群体经历了最高的事件美国的阿尔茨海默氏病和相关痴呆症（ADRD）风险。潜水员的纵向研究在早期和中年收集社会和行为措施的样本对确定ADRD风险的认知健康和生命途径的可修改保护因素。社会的关系是一种具有高干预潜力的多维概念，可以预测认知健康和ADRD，尽管这些协会在种族/种族中可能有所不同。仍未确定的是：（1）不同种族/族裔群体中的早期和中年社会关系与ADRD风险有关；和（2）改变ADRD风险的社会关系的具体方面。表征社会关系如何变化为种族/种族的功能以及与ADRD风险的独特联系将在理论和干涉。这项研究将利用三波社会关系研究以及第四波> 65个样本（目前在现场：n = 330）检查种族/族裔群体之间的社会关系和ADRD风险。我们将收集第四波的面板数据，年龄<65（n = 244）和一个新的代表性底特律大都会区采样（n = 3400），使用原始设计，现在在现场添加阿拉伯美国人并行数据收集。具体目的是：目标1：通过种族/种族在两个成人寿命中审查社会关系和健康的世俗趋势区域代表人群。目标2：确定对ADRD风险影响最大影响的社会关系的各个方面中后期生活的黑人，白人和阿拉伯美国人。目标3：确定整个生活课程与ADRD之间的社会关系之间的纵向关联黑人和白人的风险。我们利用了一项现有的纵向队列研究，对详细的社会关系超过30年不同的寿命样本（即，在波浪1中从8岁到93岁）。添加认知和遗传措施以及将种族/族裔群体比较扩展到包括阿拉伯美国人的新区域代表样本（35岁以上）提供了一个新的机会，可以研究中年的可修改因素，以实现ADRD风险。发现将提供关键信息以使用社会关系的有影响力的资源来制定策略以减少差异。此外，拟议的研究为新代表的纵向研究设定了阶段 ADRD风险中的种族/种族差异。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

ELDER ORPHANS ON FACEBOOK: IMPLICATIONS FOR MATTERING AND SOCIAL ISOLATION.

Facebook 上的老年孤儿：对重要问题和社会孤立的影响。

DOI：
10.1016/j.chb.2021.107023
发表时间：
2022
期刊：
Computers in human behavior
影响因子：
9.9
作者：
Francis,Jess
通讯作者：
Francis,Jess

Measurement and structural invariance of a neuropsychological battery among Middle Eastern/North African, Black, and White older adults.

中东/北非、黑人和白人老年人神经心理电池的测量和结构不变性。

DOI：
10.1037/neu0000902
发表时间：
2023
期刊：
Neuropsychology
影响因子：
2.4
作者：
Zahodne,LauraB;Brauer,Simon;Tarraf,Wassim;Morris,EmilyP;Antonucci,ToniC;Ajrouch,KristineJ
通讯作者：
Ajrouch,KristineJ

Exploring the Relationship between Self-Rated Health and Unmet Cancer Needs among Sexual and Gender Minority Adolescents and Young Adults with Cancer.