Pre-doctoral Training Program in Integrative Vascular Biology

综合血管生物学博士前培训项目

• 批准号: 10625918
• 负责人: Christopher P. Mack
• 金额: $ 49.64万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625918
• 关键词: Biology; Blood Vessels; Training Programs; pre-doctoral

Project Summary - The complexity of cardiovascular disease has hindered our understanding of its deveopment and progression. To uncover the mechanisms by which genetic variation and environmental factors influence cardiovascular development and disease, the next generation of scientists will need to be trained to use a variety of approaches, technologies and model systems. In response to this demand, the Integrative Vascular Biology (IVB) Pre-doctoral Training Program was established at UNC in 2002 to promote a collaborative interdisciplinary training environment for pre-doctoral students in the cardiovascular field. The IVB Program combines the breadth and depth of the cardiovascular research faculty with other research strengths at UNC in genetic model systems, state-of-the-art cell biology and imaging, high throughput genomic and proteomic analyses, and computational biology. The overall goal of the IVB Program is to provide Trainees with the interdisciplinary and collaborative skills necessary to extend their thesis work into new, innovative, and productive directions. Specific Aim 1 is to connect Trainees in broad areas of cardiovascular research by requiring them to collaborate with secondary mentors outside of their field. This training mechanism was specifically designed to “connect” graduate students in broad areas of cardiovascular biology and cardiovascular health research. The program teaches students to apply molecular, cellular, genetic, and computational approaches to pathological and physiological questions in cell, organ, and whole animal systems; to merge hypothesis- and discovery-based research; and to develop high-throughput approaches for use in complex models. Specific Aim 2 is to provide Trainees with a broad understanding of cardiovascular development and disease. This will be achieved through advanced paper-based cardiovascular courses, cardiovascular seminars by leaders in the field, and through bi-weekly student-led discussion groups. Specific Aim 3 is to enhance the skills necessary for effective collaboration and career advancement. Trainees will improve their communication skills by presenting their work at formal and informal IVB events and students will attend IVB Workshops on grant writing, career development, and scientific rigor and responsibility. The IVB Program is administered by UNC McAllister Heart Institute and is directed by Dr. Christopher Mack a respected vascular biologist who has been heavily involved in graduate student training at multiple levels. He is assisted by Associate Director, Vicki Bautch, and former IVB director Nobuyo Maeda. The major strength of the Program is the breadth and diversity of the 42 primary training faculty who are committed to graduate student training, extremely well-funded, and using cutting edge approaches to answer a wide-variety of cardiovascular questions. When combined with a well-developed academic program in Cardiovascular Science (also directed by Dr. Mack) and a large pool of well-qualified applicants, the UNC Integrative Vascular Biology Program offers an outstanding environment for multidisciplinary training of pre-doctoral students.

项目摘要 - 心血管疾病的复杂性阻碍了我们对其的理解 发展和发展。揭示遗传变异和环境的机制 因素影响心血管发育和疾病，下一代科学家将需要 经过培训，可以使用各种方法，技术和模型系统。为了应对这一需求， 综合血管生物学（IVB）于2002年在UNC建立了博士前培训计划，以促进 为心血管领域的博士前学生提供的协作跨学科培训环境。 IVB 计划将心血管研究教师的广度和深度与其他研究优势相结合 在遗传模型系统中的UNC，最先进的细胞生物学和成像，高通量基因组和 蛋白质组学分析和计算生物学。 IVB计划的总体目标是为受训者提供 凭借将论文工作扩展到新的跨学科和协作技能， 创新和产品方向。具体目标1是将受训者连接到 心血管研究通过要求他们与领域外的二级导师合作。这 培训机制专门设计用于在心血管范围内“连接”研究生 生物学和心血管健康研究。该计划教学生应用分子，细胞， 细胞，器官和整个病理和物理问题的遗传和计算方法 动物系统；合并假设和基于发现的研究；并发展高通量 用于复杂模型的方法。具体目标2是为受训者提供广泛的了解 心血管发育和疾病。这将通过基于高级纸质的心血管实现 该课程，该领域领导者的心血管半段，以及每两周由学生主导的讨论小组。 具体目标3是增强有效的协作和职业发展所需的技能。学员 通过在正式和非正式的IVB活动中介绍他们的工作和学生，将提高他们的沟通能力 将参加有关赠款写作，职业发展以及科学严谨和责任的IVB研讨会。 IVB 程序由UNC McAllister Heart Institute管理，由Christopher Mack A博士执导 受人尊敬的血管生物学家，他们在多个级别上大量参与研究生培训。他是 由副主任Vicki Bautch和前IVB董事Nobuyo Maeda协助。主要优势 该计划是致力于毕业的42位小学培训学院的广度和多样性 学生培训，资金丰富，并采用最先进的方法来回答广泛的变化 心血管问题。与心血管科学领域发达的学术课程结合在一起时 （也由Mack博士执导）和大量合格的应用，UNC综合血管生物学 计划为博士前学生的多学科培训提供了一个杰出的环境。

项目成果

Topically applied manganese-porphyrins BMX-001 and BMX-010 display a significant anti-inflammatory response in a mouse model of allergic dermatitis.

局部应用锰卟啉 BMX-001 和 BMX-010 在过敏性皮炎小鼠模型中显示出显着的抗炎反应。

• DOI: 10.1007/s00403-016-1693-0
• 发表时间: 2016
• 期刊: Archives of dermatological research
• 影响因子: 3
• 作者: Stover,Kelsey;Fukuyama,Tomoki;Young,AshlynT;Daniele,MichaelA;Oberley,Rebecca;Crapo,JamesD;Bäumer,Wolfgang
• 通讯作者: Bäumer,Wolfgang

Microfluidic and Organ-on-a-Chip Approaches to Investigate Cellular and Microenvironmental Contributions to Cardiovascular Function and Pathology.

• DOI: 10.3389/fbioe.2021.624435
• 发表时间: 2021
• 期刊: Frontiers in bioengineering and biotechnology
• 影响因子: 5.7
• 作者: Doherty EL;Aw WY;Hickey AJ;Polacheck WJ
• 通讯作者: Polacheck WJ

Acoustic Angiography: Superharmonic Contrast-Enhanced Ultrasound Imaging for Noninvasive Visualization of Microvasculature.

声血管造影：超谐波对比增强超声成像，用于微血管系统的无创可视化。

• DOI: 10.1007/978-1-0716-1803-5_34
• 发表时间: 2022
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Newsome,IsabelG;Dayton,PaulA
• 通讯作者: Dayton,PaulA

Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis.

• DOI: 10.2337/db13-1070
• 发表时间: 2015-01
• 期刊: Diabetes
• 影响因子: 7.7
• 作者: Li LO;Grevengoed TJ;Paul DS;Ilkayeva O;Koves TR;Pascual F;Newgard CB;Muoio DM;Coleman RA
• 通讯作者: Coleman RA

Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration.

• DOI: 10.1016/j.coph.2015.10.001
• 发表时间: 2016-02
• 期刊: Current opinion in pharmacology
• 影响因子: 4
• 作者: Chen SH;Oyarzabal EA;Hong JS
• 通讯作者: Hong JS