Shared Resources Management

共享资源管理

• 批准号: 10625760
• 负责人: Steven James Madore
• 金额: $ 4.36万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625760
• 关键词: Abbreviations; Area; Artificial Intelligence; Award; Biometry; Biotechnology; CCL21 gene; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Control; Capital; Clinical; Clinical Cancer Center; Clinical Trials; Clustered Regularly Interspaced Short Palindromic Repeats; Complex; Confocal Microscopy; Cost Savings; Cytometry; Development; Direct Costs; Doctor of Philosophy; Effectiveness; Ensure; Epigenetic Process; Experimental Designs; Faculty; Feedback; Florida; Flow Cytometry; Funding; Future; Genetic Research; Goals; Grant; Health; Hour; Immune response; Immunologist; Immunophenotyping; Immunotherapy; Informatics; Infrastructure; Institution; Institutional Policy; Investments; Laboratories; Last Name; Leadership; Libraries; Malignant Neoplasms; Microscopy; Monitor; Peer Review; Peer Review Grants; Policies; Population Sciences; Postdoctoral Fellow; Procedures; Process; Publications; Quality Control; RNA vaccine; Reagent; Reproducibility; Research; Research Priority; Research Support; Resource Sharing; Resources; Robot; Role; Science; Services; Strategic Planning; Surveys; System; Technology; Testing; Text; Therapeutic; Training; Translational Research; Universities; Update; Wages; anticancer research; cancer genomics; career development; college; cost effective; design; equipment acquisition; experience; federal policy; first-in-human; genomic data; instrument; instrumentation; machine learning method; member; microbiome; new technology; next generation sequencing; novel; power analysis; programs; recruit; research facility; research study; response; screening; service member; transcriptome sequencing; transcriptomics; treatment response; tumor; tumorigenesis; ultra high resolution; vaccine trial; Abbreviations; Area; Artificial Intelligence; Award; Biometry; Biotechnology; CCL21 gene; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Control; Capital; Clinical; Clinical Cancer Center; Clinical Trials; Clustered Regularly Interspaced Short Palindromic Repeats; Complex; Confocal Microscopy; Cost Savings; Cytometry; Development; Direct Costs; Doctor of Philosophy; Effectiveness; Ensure; Epigenetic Process; Experimental Designs; Faculty; Feedback; Florida; Flow Cytometry; Funding; Future; Genetic Research; Goals; Grant; Health; Hour; Immune response; Immunologist; Immunophenotyping; Immunotherapy; Informatics; Infrastructure; Institution; Institutional Policy; Investments; Laboratories; Last Name; Leadership; Libraries; Malignant Neoplasms; Microscopy; Monitor; Peer Review; Peer Review Grants; Policies; Population Sciences; Postdoctoral Fellow; Procedures; Process; Publications; Quality Control; RNA vaccine; Reagent; Reproducibility; Research; Research Priority; Research Support; Resource Sharing; Resources; Robot; Role; Science; Services; Strategic Planning; Surveys; System; Technology; Testing; Text; Therapeutic; Training; Translational Research; Universities; Update; Wages; anticancer research; cancer genomics; career development; college; cost effective; design; equipment acquisition; experience; federal policy; first-in-human; genomic data; instrument; instrumentation; machine learning method; member; microbiome; new technology; next generation sequencing; novel; power analysis; programs; recruit; research facility; research study; response; screening; service member; transcriptome sequencing; transcriptomics; treatment response; tumor; tumorigenesis; ultra high resolution; vaccine trial

SHARED RESOURCE MANAGEMENT: ABSTRACT The University of Florida Health Cancer Center (UFHCC) members benefit from access to the UFHCC-managed Biostatistics and Quantitative Sciences Shared Resource (BQS-SR) and the institutionally-managed Flow Cytometry and Confocal Microscopy Shared Resource (CYT-SR) and Next Generation Sequencing Shared Resource (NGS-SR). With nearly 25 years of experience in shared resource management, Madore (ZY), UFHCC Associate Director for Shared Resources and UF Interdisciplinary Center for Biotechnology Research Associate Director for Science, manages the shared resources (SR) to drive novel discoveries through member access to cost-effective, leading-edge instrumentation, and quantitative science expertise. The SR Management goals are to: 1) identify and evaluate SR needs of the membership to support existing centralized SRs and develop new SRs; 2) establish standard operating procedures, facilitate regular staff training, and assure quality control processes for rigor and reproducibility of research; 3) leverage existing institutional resources to create and expand services and continuously evaluate new technologies to meet member needs; 4) monitor effectiveness of SRs through membership surveys and advisory oversight groups; 5) establish and maintain policies for optimal SR capacity and maximal access; and 6) centralize fiscal planning and billing management systems in compliance with institutional and federal policies. SR funding comes from an established chargeback system, institutional resources, direct grant support, and strategic partnerships with the UF Office of Research and UF Colleges. A member of the UFHCC Executive Committee, Madore chairs the UFHCC SR Oversight Committee that supervises SR Management in alignment with the UFHCC Strategic Plan. Scientific Advisory Groups for each SR provide faculty-guided feedback and advice. Since 2016, UF institutional commitment for SRs includes salary subsidy for 9 staff members in the institutionally-managed CYT and NGS-SRs and $1.5M in capital equipment investment. Leveraging this continuous support, UFHCC contributed $1.7M for instrumentation acquisitions and enhancements in CYT-SR and NGS-SR. UFHCC recruited 6 new biostatisticians and bioinformaticians in the BQS-SR (~$1.4M investment to date) and supported a PhD immunologist in the CYT-SR to perform flow-based immunophenotyping for a first-in-human therapeutic tumor RNA vaccine trial. Since 2016, the BQS-SR, CYT-SR, and NGS-SR contributed to 574 cancer-focused publications (19% with impact factors ≥10) and supported $117.4M (direct costs, all years) in peer-reviewed grants. Since 2016, 222 UFHCC users accessed BQS-SR, 78 utilized CYT-SR, and 54 utilized NGS-SR. Future plans, in alignment with the UFHCC strategic plan, Momentum 2027, include expanding the SR services portfolio through acquisition of new instrumentation and technology (e.g., spatial transcriptomics, super high- resolution microscopy), supporting BQS-SR in implementing artificial intelligence/machine learning methods, and leading the formation of two UFHCC developing SRs in response to membership needs.

共享资源管理：摘要 佛罗里达大学健康癌症中心（UFHCC）成员受益于对UFHCC管理的访问 生物统计学和定量科学共享资源（BQS-SR）和机构管理的流程 细胞仪和共聚焦显微镜共享资源（CYT-SR）和下一代测序共享 资源（NGS-SR）。拥有将近25年的共享资源管理经验，Madore（ZY）， UFHCC共享资源和UF跨学科生物技术研究中心副主任 科学副主任，管理共享资源（SR）通过成员推动新发现 获得具有成本效益，领先的仪器和定量科学专业知识。 SR管理 目标是：1）确定和评估会员资格的SR需求，以支持现有的集中式SR和 开发新的SRS； 2）建立标准操作程序，促进定期的员工培训并确保质量 严格和可重复性的控制过程； 3）利用现有的机构资源来创建 并扩大服务并不断评估新技术以满足会员需求； 4）监视器 通过会员调查和咨询监督小组，SRS的有效性； 5）建立和维护 最佳SR容量和最大访问权限的政策； 6）集中财政计划和计费管理 符合机构和联邦政策的系统。 SR资金来自既定的退款 系统，机构资源，直接赠款支持以及与UF研究办公室的战略合作伙伴关系 和UF大学。 Madore主席UFHCC执行委员会的成员UFHCC SR监督 与UFHCC战略计划保持一致的SR管理委员会。科学咨询 每个SR的小组都提供教师指导的反馈和建议。自2016年以来，UF机构承诺 SRS包括用于机构管理的CYT和NGS-SRS的9名工作人员的薪资补贴和150万美元 资本设备投资。利用这种连续的支持，UFHCC为170万美元贡献了 CYT-SR和NGS-SR的仪器采集和增强。 UFHCC招募了6个新 BQS-SR的生物统计学家和生物信息学家（迄今为止投资约140万美元），并支持博士学位 CYT-SR中的免疫学家对首次人类治疗肿瘤进行基于流动的免疫表型 RNA疫苗试验。自2016年以来，BQS-SR，Cyt-SR和NGS-SR贡献了574个以癌症为中心的 出版物（19％的影响因素≥10），并在同行评审中支持1.174亿美元（直接费用，所有年） 赠款。自2016年以来，222位UFHCC用户访问了BQS-SR，78个使用的CYT-SR和54个使用的NGS-SR。未来 计划与UFHCC战略计划（Momentum 2027）保持一致，包括扩大SR服务 通过获取新仪器和技术的投资组合（例如，空间转录组学，超级高 分辨率显微镜），支持BQS-SR实现人工智能/机器学习方法， 并领导两个UFHCC的形成，以响应成员资格需求而开发SRS。