Effect of exercise modality during pregnancy on childhood obesity risk

孕期运动方式对儿童肥胖风险的影响

• 批准号: 10618265
• 负责人: Linda E May
• 金额: $ 66.23万
• 依托单位: EAST CAROLINA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-15 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618265
• 关键词: Abdomen; Adult; Aerobic; Aerobic Exercise; Age; Age Months; American College of Obstetricians and Gynecologists; Attenuated; Biological Markers; Birth; Birth Weight; Blood Pressure; Body fat; Body mass index; C-reactive protein; Cardiovascular Diseases; Child; Child Health; Childhood; Cholesterol; Conceptions; Control Groups; Data; Disease; Enrollment; Environment; Exercise; Exhibits; Gestational Diabetes; Goals; Growth; Guidelines; Habits; Health; Heart Rate; Hyperglycemia; Hyperinsulinism; Hyperlipidemia; Hypertension; Incidence; Infant; Infant Health; Inflammatory; Life; Lipids; Longitudinal Studies; Low-Density Lipoproteins; Maternal Health; Measurement; Measures; Metabolic; Metabolic Diseases; Metabolic dysfunction; Metabolic syndrome; Methods; Morbidity - disease rate; Mothers; Motor; Obesity; Outcome; Outcome Assessment; Overweight; Pathway interactions; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Pregnant Women; Public Health; Randomized; Randomized, Controlled Trials; Recommendation; Research; Resistance; Risk; Risk Marker; Target Populations; Testing; Time; United States; Weight; Weight Gain; Woman; Work; antenatal; cardiometabolic risk; cardiometabolism; cardiovascular disorder risk; clinical practice; design; effective intervention; efficacious intervention; exercise intervention; exercise training; fetal; glucose metabolism; heart function; improved; improved outcome; in utero; infant outcome; innovation; insight; insulin sensitivity; intergenerational; longitudinal, prospective study; maternal obesity; maternal weight; metabolomics; mode of exercise; mortality; next generation; obese mothers; obesity in children; obesity prevention; obesity risk; offspring; overweight child; prenatal; programs; recruit; resistance exercise; skills; treatment as usual

Project Abstract The in-utero environment, including maternal weight gain and exercise habits, can “program” a child towards disease or health after birth and into adulthood. The often-intergenerational cycle of obesity begins with a significant number of women who are overweight or obese (OW/OB) at the time of conception and throughout pregnancy; these women are more likely to give birth to infants who are macrosomic. By age 5, overweight (OW) children already have signs of metabolic syndrome and cardiovascular disease risks (e.g. obesity, hyperlipidemia, hyperglycemia, hyperinsulinemia, and hypertension). While research has demonstrated benefits of both aerobic and resistance exercise for pregnant women as well as decreased adiposity and improved motor/heart function in their infants, no studies have been done to determine which exercise modes are most beneficial for mother and baby when a woman is overweight or obese at the time of conception. For adults in general, combined aerobic and resistance exercise (AERE) delivers the greatest metabolic improvements (e.g. increased insulin sensitivity, improved heart function, decreased adiposity). Therefore, the purpose of this study is to identify which prenatal exercise type(s) will elicit the greatest positive impact on maternal and infant health while reducing metabolic risk markers in OW/OB pregnant women relative to non-exercising counterparts. Using a randomized design, 284 pregnant women will undergo an exercise intervention (AE, RE, AERE) from enrollment (~13-16 weeks gestation) until delivery (~40 weeks gestation). The central hypothesis of this study is that adding RE improves outcomes; thus, the COMBINATION of aerobic and resistance exercise not only will improve infant cardiometabolic health outcomes, as compared to AE alone, but will have the best compliance of all groups. We will test this hypothesis with two specific aims to: (1) Determine the influence of different exercise modes during OW/OB pregnancy on infant cardiometabolic health and growth trajectories; and (2) Determine the most effective exercise mode in OW/OB pregnancy on improving maternal cardiometabolic health. Methods will include measurements such as weight, abdominal circumference, blood pressure, lipids, and other biomarkers for both mothers and infants. The study will also track maternal and infant cardiometabolic outcomes through the post-partum period, up to 12 months. This work has the potential to impact clinical practice by revealing the earliest and most effective intervention to reduce the intergenerational cycle of metabolic dysfunction, including obesity, in women and children. .

项目摘要 子宫内环境，包括母亲的体重增加和锻炼习惯，可以“编程”孩子 出生后和成年后的疾病或健康 肥胖通常是代际循环开始的。 大量女性在受孕时和整个过程中超重或肥胖 (OW/OB) 怀孕；这些女性更有可能在 5 岁时生下超重 (OW) 的巨大婴儿。 儿童已经出现代谢综合征和心血管疾病风险的迹象（例如肥胖、 虽然研究已证明其益处，但高脂血症、高血糖、高胰岛素血症和高血压）。 孕妇的有氧运动和抗阻运动以及减少肥胖和改善 婴儿的运动/心脏功能，尚未进行研究来确定哪种运动模式最有效 当女性在受孕时超重或肥胖时，对母亲和婴儿有益。 一般而言，有氧运动和抗阻运动相结合 (AERE) 可实现最大的代谢改善（例如， 增加胰岛素敏感性，改善心脏功能，减少肥胖）。 旨在确定哪种产前运动类型将对孕产妇和婴儿健康产生最大的积极影响 相对于不运动的体重，同时降低 OW/OB 孕妇的代谢风险标志物。 在一项随机设计中，284 名孕妇将接受运动干预（AE、RE、AERE） 入组（妊娠约 13-16 周）直至分娩（妊娠约 40 周）。 添加 RE 可以改善结果；因此，有氧运动和抗阻运动的结合不仅可以改善效果； 与单独的 AE 相比，可改善婴儿心脏代谢健康结果，但具有最佳的依从性 我们将通过两个具体目标来检验这一假设：（1）确定不同运动的影响。 OW/OB 妊娠期间的模式对婴儿心脏代谢健康和生长轨迹的影响；以及 (2) 确定 OW/OB 妊娠中改善母亲心脏代谢健康最有效的运动模式。 将包括体重、腹围、血压、血脂等测量数据 该研究还将跟踪母亲和婴儿的心脏代谢结果。 这项工作有可能影响产后长达 12 个月的临床实践。 揭示了减少代谢代际循环的最早、最有效的干预措施 妇女和儿童的功能障碍，包括肥胖。 。