WOMEN AND INFANTS TRANSMISSION STUDY (WITSIII)

妇女和婴儿传播研究 (WITSIII)

• 批准号: 2394150
• 负责人: William Thomas Shearer
• 金额: $ 133.18万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2394150
• 关键词: AIDS /HIV diagnosis; AIDS therapy; HIV infections; antiAIDS agent; child (0-11); clinical research; clinical trials; cooperative study; female; human pregnant subject; human subject; human therapy evaluation; human tissue; longitudinal human study; pathologic process; pediatric AIDS; pregnancy immunology; urban poverty area; vertical transmission

This is the Baylor College of Medicine (BCM)-University of Texas Medical School in Houston (UT) application for Part III of the Women and Infants Transmission Study (WITS). BCM-UT has been an active participant in WITS II endeavors through award of cooperative agreement U01-AI34840-01 in July 1993. Since 1988, BCM-UT has established liaisons with providers who care for a large maternal-infant population infected with human immunodeficiency virus (HIV). These providers make up National Institutes of Health (NIH)-sponsored Pediatric Obstetrical HIV RESEARCH CENTER at BCM and UT. BCM-UT seeks to continue to perform WITS research as part of its coordinated recruitment of HIV-infected mother-infant pairs into natural history, diagnostic, and therapeutic clinical trial programs. By using the combined strengths of other NIH-funded research, including basic science awards, and the facilities of the General Clinical Research Center (GCRC) at the BCM-affiliated Texas Children's Hospital, it will be possible to continue to enroll 50 mother-infant pairs per year into WITS with greatest economy of financial resources. The following research aims are identified for WITS III: (1) to determine material co-factors related to maternal-infant HIV transmission, including assessment of mechanisms and timing of transmission, (2) to evaluate strategies related to success/failure of perinatal intervention including gestational/postnatal antiretroviral therapy, (3) to determine the impact of pregnancy with/without antiretroviral therapy on the natural history of HIV infection among women through the postpartum period, including immunologic and virologic changes in pregnant HIV-infected women (4) to assess acute HIV infection among both infants and women in light of antiretroviral, prophylactic and immune-based therapy, and (5) to assess factors which might predict disease progression among the cohort of HIV infected children in WITS. Subjects will be recruited through the hospital and clinics affiliated with BCM and UT, private pediatricians and obstetricians in the Houston metropolitan area, and the indigent care clinic system maintained by the Harris County Hospital District Authority. Maternal consent will be obtained after the diagnosis of HIV infection has been documented.

这是德克萨斯州贝勒医学院（BCM） 休斯敦（UT）的医学院申请妇女第三部分 和婴儿传播研究（WITS）。 bcm-ut一直是活跃的 参与Wits II通过合作的努力 协议U01-AI34840-01在1993年7月。自1988年以来，BCM-ut拥有 与供应商建立的联络人，他们关心大型产妇的联络 感染人类免疫缺陷病毒（HIV）的人群。 这些 提供者组成国家卫生研究院（NIH）赞助的 BCM和UT的小儿产科HIV研究中心。 BCM-ut试图继续进行机智研究 协调招募HIV感染的母子成对 自然病史，诊断和治疗性临床试验计划。 经过 利用其他NIH资助的研究的综合优势，包括 基础科学奖和一般临床的设施 BCM附属德克萨斯州儿童研究中心（GCRC） 医院，可以继续注册50个母亲 每年将财务资源经济最大的机智融入到智慧中。 以下研究目的是针对WITS III的：（1）至 确定与产妇艾滋病毒有关的材料副因素 传输，包括评估机制和时间安排 传输，（2）评估与成功/失败有关的策略 围产期干预措施，包括妊娠/产后抗逆转录病毒 治疗，（3）确定与/没有/没有的怀孕的影响 抗逆转录病毒疗法关于艾滋病毒感染的自然史 妇女在产后期间，包括免疫学和 怀孕的HIV感染妇女的病毒学变化（4）评估急性 根据抗逆转录病毒，婴儿和妇女的HIV感染， 预防性和基于免疫的治疗，以及（5）评估因素 这可能可以预测艾滋病毒队列中疾病的进展 感染了智慧的孩子。 受试者将通过医院和诊所隶属招募 与BCM和UT一起，私人儿科医生和产科医生 休斯顿都会区和贫穷的护理诊所系统 由哈里斯县医院地区管理局维护。 诊断为HIV感染后将获得孕产妇同意 已被记录。