CORE--NEUROPATHOLOGY

核心--神经病理学

• 批准号: 6099480
• 负责人: FRANCES K CONLEY
• 金额: --
• 依托单位: PALO ALTO MEDICAL FOUNDATION RES INST
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6099480
• 关键词: biomedical facility; encephalitis; histopathology; toxoplasmosis

The Neuropathology Core was developed to provide on-going support to the major investigators in the Drug Discovery project that is working to find a treatment for toxoplasmosis in the AIDS patient. The critical element served by this Core is to provide a means of measuring successful drug therapy by histologic methods so that there is not total reliance on survival data for evaluation of efficacy of a particular drug regime. The histologic changes in the brain and heart of immune-competent mice infected with toxoplasma are well known and characterized. Extensive experience with toxoplasma infection in immune-compromised mice and humans with AIDS or organs transplant has permitted us to delineate a continuum of histologic changes that correlate well with the clinical course of infection in a particular patient or mouse. The assessment of degree of involvement by infection in a particular patient or mouse. The assessment of degree of involvement by infection in a particular organ is always done in a blinded fashion so that identity of treated groups as well as the particular drug regime under investigation are not known to the person reading histological slides. In our past studies, true differences in various drug therapy on efficacy of containing the toxoplasma infection are easily discerned by evaluating the histology, particularly that of the brain. Immunoperoxidase staining for toxoplasma antigen will be of increasing importance as these studies continue because in the immunocomprised patient eradication of infection rather than simple control is essential, and this staining allows identification of dormant organisms in infected tissues.

神经病理学核心旨在为持续的支持提供 药物发现项目的主要研究人员正在努力找到 艾滋病患者的弓形虫病治疗。 关键要素 该核心服务是提供一种测量成功药物的方法 通过组织学方法的治疗，因此不完全依赖 用于评估特定药物制度疗效的生存数据。 免疫能力小鼠的大脑和心脏的组织学变化 被弓形虫感染的是众所周知的和表征。 广泛的 免疫受损小鼠中弓形虫感染的经验 具有艾滋病或器官移植的人类使我们可以描绘 组织学变化的连续性与临床良好相关 特定患者或老鼠的感染过程。 评估 特定患者或小鼠的感染参与程度。 这 评估特定器官中感染参与程度 总是以盲目的方式完成，以使治疗群体的身份 以及正在调查的特定药物制度尚不清楚 给阅读组织学幻灯片的人。 在过去的研究中，是真的 各种药物疗法的差异在包含 通过评估组织学，很容易辨别弓形虫感染， 特别是大脑的。 弓形虫的免疫过氧化物酶染色 随着这些研究的继续，抗原将越来越重要 因为在免疫机敏的患者消除感染中 比简单的控制是必不可少的，这种染色允许识别 感染组织中休眠生物的。