Validating RDoC for Children and Adolescents: A Twin Study with Neuroimaging

验证儿童和青少年的 RDoC：神经影像学双胞胎研究

基本信息

批准号：
9301026
负责人：
Harold Hill Goldsmith
金额：
$ 56.16万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-14 至 2021-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9301026
关键词：
14 year old 18 year old 7 year old Acute Address Adolescent Adult Affect Affective Age Amygdaloid structure Anterior Anxiety Area Behavior Behavior assessment Behavioral Biometry Birth Records Brain Child Child Behavior Childhood Corpus striatum structure Data Data Collection Development Diagnosis Diffusion Magnetic Resonance Imaging Dimensions Fright Frustration Functional Magnetic Resonance Imaging Gender Genetic Hydrocortisone Image Impairment Incentives Individual Individual Differences Individuality Magnetic Resonance Imaging Maps Measurement Measures Mental Health Methods Modality National Institute of Mental Health Nature Negative Valence Neuropsychology Participant Patient Self-Report Pattern Phenotype Physiology Positive Valence Psychophysiology Puberty Quantitative Genetics Recovery Recovery of Function Research Domain Criteria Rest Rewards Same-sex Sampling Specific qualifier value Spin Labels Stimulus Stress Subgroup Symptoms System Testing Time Toddler Twin Multiple Birth Twin Studies Variant Videotape base behavior measurement behavioral construct clinically relevant cognitive ability design emotion regulation follow-up longitudinal analysis multimodality negative affect neural circuit neuroimaging public health relevance relating to nervous system response reward circuitry stability testing

项目摘要

DESCRIPTION (provided by applicant): This application proposes a two-part approach to understanding developmental aspects of the RDoC positive and negative valence systems. The project focuses on objective behavioral assessment and multimodal neuroimaging. Study 1 takes advantage of 1404 children (702 twin pairs) previously objectively assessed as 7 year-olds on positive and negative affect with a battery of videotaped behavioral measures that map onto RDoC dimensions. These children had also been assessed as toddlers and were later assessed at mean age 14 years, which allows for longitudinal tests of construct validity of the RDoC systems as applied to children. Study 1 includes completion of the age 14 data collection. Study 2 proposes to follow-up, at mean age 18 years, 640 of these participants (320 same-sex twin pairs) with comprehensive neuroimaging and concurrent psychophysiological and neuropsychological measures that assess selected RDoC constructs from the positive and negative valence systems. We will determine whether standing on the childhood RDoC measures (from Study 1) predicts adolescent neuroimaging measures of reactivity and recovery of positive and negative affect (from Study 2). We will test predictions concerning correlates of standing on RDoC constructs using structural and functional connectivity and dynamic features (reactivity and recovery) of responses to affective stimuli in an automatic emotion regulation task. We use the twin design to discern whether individual differences are genetically conditioned and whether the covariance across time (stability of RDoC) and the covariance between behavioral and neural measures (neural underpinnings of RDoC) have genetic bases. We investigate environmental bases of RDoC constructs by predicting monozygotic intrapair differences in neuroimaging parameters from earlier intrapair behavioral RDoC differences and from earlier measures of adversity and stress.

描述（由申请人提供）：本申请提出了一种由两部分组成的方法来理解 RDoC 正价和负价系统的发展方面。该项目侧重于客观行为评估和多模式神经影像学。研究 1 利用了 1404 名儿童（702 对双胞胎），他们之前在 7 岁时通过一系列映射到 RDoC 维度的录像行为测量进行了积极和消极影响的客观评估。这些儿童在幼儿时也接受过评估，后来在平均年龄 14 岁时接受评估，这样可以对应用于儿童的 RDoC 系统的结构有效性进行纵向测试。研究 1 包括完成 14 岁数据收集。研究 2 计划对 640 名平均年龄为 18 岁的参与者（320 对同性双胞胎）进行随访，采用全面的神经影像学和同时进行的心理生理学和神经心理学测量，以评估正负价系统中选定的 RDoC 结构。我们将确定儿童 RDoC 测量（来自研究 1）的站立是否可以预测青少年神经影像学测量的积极和消极情感的反应性和恢复（来自研究 2）。我们将使用自动情绪调节任务中对情感刺激的反应的结构和功能连接以及动态特征（反应性和恢复）来测试有关 RDoC 构建的站立相关性的预测。我们使用孪生设计来辨别个体差异是否受到遗传调节，以及随时间的协方差（RDoC 的稳定性）以及行为和神经测量之间的协方差（RDoC 的神经基础）是否具有遗传基础。我们通过根据早期的对内行为 RDoC 差异以及早期的逆境和压力测量来预测神经影像参数的同卵对内差异，从而研究 RDoC 构造的环境基础。